中文名 | 5-羟基癸酸钠盐 |
英文名 | sodium 5-hydroxydecanoate |
别名 | 5-羟基癸酸钠盐 |
英文别名 | 5-Hydroxydecanoate 5-HYDROXYDECANOATE NA Sodium 5-hydroxydecanoate sodium 5-hydroxydecanoate 5-Hydroxydecanoate sodium 5-HYDROXYDECANOIC ACID SODIUM 5-HYDROXYDECANOIC ACID SODIUM SALT 5-Hydroxydecanoic acid sodium salt,5-hydroxydecanoate sodium salt |
CAS | 71186-53-3 |
化学式 | C10H19NaO3 |
分子量 | 210.25 |
InChI | InChI=1/C10H20O3.Na/c1-2-3-4-6-9(11)7-5-8-10(12)13;/h9,11H,2-8H2,1H3,(H,12,13);/q;+1/p-1 |
沸点 | 320.8°C at 760 mmHg |
闪点 | 162°C |
蒸汽压 | 2.52E-05mmHg at 25°C |
溶解度 | H2O: 可溶 |
存储条件 | desiccated |
外观 | 固体 |
颜色 | white |
体外研究 | 5-Hydroxydecanoate (5-HD) treatment abolishs the beneficial effects of penehyclidine hydrochloride (PHC) preconditioning in anoxia/reoxygenation (A/R)‐induced injury in H9c2 cells. 5-Hydroxydecanoate blocks the inhibitory effect of PHC on Ca 2+ overload and ROS production. 5-Hydroxydecanoate promotes the release of Cyt-C from mitochondria into cytoplasm. 5-Hydroxydecanoate attenuats the anti-apoptotic effect of PHC. PHC treatment shows remarkably decreases levels of Bax and cleaved caspase-3, and increases levels of Bcl-2. 5-Hydroxydecanoate pretreatment reverses the effects of PHC on their expression levels. 5-Hydroxydecanoate blocks the effects of PHC on K ATP channels. |
体内研究 | 5-Hydroxydecanoate (100 μM) treatment abolishes the effects of ischemic preconditioning (IPC) on the contractile recovery and does not affect its effect on the contracture, lactate production, glycogenolysis and viable tissue in rats. |
WGK Germany | 3 |