中文名 | 一叶萩碱 |
英文名 | Securinine |
别名 | 一叶碱 一叶萩碱 叶底珠碱 硝酸一叶秋碱 一叶秋碱 ,一叶萩碱 一叶秋碱 , 来源于叶底珠 一叶秋碱 ,一叶萩碱(标准品) SECURININE 一叶萩碱 |
英文别名 | securinin SECURININE Securinine (-)-securinin (-)-SECURININE SECURAN-11-ONE SECURININE(RG) Securinan-11-on securinan-11-one |
CAS | 5610-40-2 |
EINECS | 694-738-6 |
化学式 | C13H15NO2 |
分子量 | 217.26 |
密度 | 1.30±0.1 g/cm3 (20 ºC 760 Torr) |
熔点 | 140-1420C |
沸点 | 357.82°C (rough estimate) |
比旋光度 | D20 -1042° (c = 1 in alc) |
溶解度 | DMSO: ≥ 25 mg/mL |
折射率 | 1.5300 (estimate) |
酸度系数 | 8.29±0.20(Predicted) |
存储条件 | Sealed in dry,2-8°C |
外观 | 粉末 |
颜色 | yellow |
物化性质 | 黄色结晶粉末,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于大戟科植物叶底珠的嫩枝叶或根,叶下珠。 |
MDL号 | MFCD00078775 |
体外研究 | (-)-Securinine is a major plant-derived alkaloid and also a GABA A receptor antagonist. (-)-Securinine is significantly potent on HeLa cells growth inhibition with IC 50 values of 7.02±0.52 μg/mL (32.3 μM). (-)-Securinine induces apoptosis in a dose-dependent manner in the tested cells, increases the percentage of ROS positive cells and depolarized cells as well as stimulates the activity of ERK1/2, caspase-9 and -3/7. (-)-Securinine also induces cell cycle arrest in S phase. Real-time PCR analysis shows high expression of tumor necrosis factor receptor superfamily (TNFRSF) genes in the cells stimulated with (-)-Securinine. |
体内研究 | In this tumor model, tumor growth is significantly impaired with (-)-Securinine treatment indicating that (-)-Securinine has potential as an Acute Myeloid Leukemia (AML) therapeutic. (-)-Securinine treated mice (n=5 mice, bilateral tumors), exhibit an average of more than 75% smaller tumors than vehicle treated mice at the end of the study period. |
危险品标志 | T - 有毒物品 Xn - 有害物品 |
风险术语 | R23/24/25 - 吸入、皮肤接触及吞食有毒。 R22 - 吞食有害。 |
安全术语 | S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。 S45 - 若发生事故或感不适,立即就医(可能的话,出示其标签)。 |
WGK Germany | 3 |
RTECS | VS4115000 |
参考资料 展开查看 | 1. [IF=6.514] Wen Hou et al."Novel virosecurinine bivalent mimetics as potent reversal agents against P-glycoprotein-mediated multidrug resistance."Eur J Med Chem. 2019 Dec;183:111726 |