中文名 | L-甲状腺素 |
英文名 | L-Thyroxine |
别名 | 左甲状 甲狀腺素 甲四碘胺 左甲状腺素 L-甲状腺素 L-甲壮腺素 左旋甲状腺素 2-甲状腺素 D-Α-生育酚 D-ALPHA-生育酚 L-甲状腺素(标准品) 3,5,3',5'-四碘甲状腺胺酸 L-THYROXINE L-甲状腺素 O-(4-羟基-3,5-二碘苯基)-3,5-二碘-L-酪氨酸 L-Β-(3,5-二磺-4-羟基苯氧基)-3,5-二磺苯丙氨酸 |
英文别名 | l-t4 L-Thyroxine t4(hormone) levothyroxine tetraiodothyronine 3,5,3',5'-tetraiodothyronine 3,5,3',5'-tetraiodothyronine l-3,5,3',5'-tetraiodothyronine 3,3',5,5'-TETRAIODO-L-THYRONIN l-3,5,3',5'-tetraiodothyronine 3,5,3',5'-TETRAIODO-L-THYRONINE o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-l-tyrosin O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine β-((3,5-Diiodo-4-hydroxyphenoxy)-3,5-diiodophenyl)alanine 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-alanine beta-[(3,5-diiodo-4-hydroxyphenoxy)-3,5-diiodophenyl]alanine |
CAS | 51-48-9 |
EINECS | 200-101-1 |
化学式 | C15H11I4NO4 |
分子量 | 776.87 |
InChI | InChI=1/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 |
InChIKey | XUIIKFGFIJCVMT-LBPRGKRZSA-N |
密度 | 2.4440 (estimate) |
熔点 | 235 °C |
沸点 | 576.3±50.0 °C(Predicted) |
比旋光度 | -5 º (1N NaOH:EtOH 1:2) |
闪点 | 9℃ |
水溶性 | insoluble |
蒸汽压 | 4.02E-14mmHg at 25°C |
溶解度 | 溶于甲醇中的4m氢氧化铵,浓度为50mg/ml |
折射率 | 1.795 |
酸度系数 | 2.2(at 25℃) |
存储条件 | Keep in dark place,Inert atmosphere,2-8°C |
敏感性 | Light Sensitive |
外观 | 粉末 |
颜色 | White to Pale Brown |
Merck | 9491 |
BRN | 2228515 |
物化性质 | 白色结晶。Mp235-236℃(分解),比旋光度[α]20D-4.4°(3%,0.13 mol/L 氢氧化钠,70%乙醇),在0.4 mol/L NaOH溶液中325nm波长处有最大吸收、0.4mol/L HCl溶液中295nm波长处有最大吸收。本品溶于碱溶液,不溶于水、乙醇和乙醚。 |
MDL号 | MFCD00002595 |
体内研究 | Deiodinases (DIOs), which catalyse the conversion of thyroxine (pro-hormone) to the active thyroid hormone, are associated with thyroid stimulating hormone (TSH) levels. DIO1 and DIO2 catalyze activation of thyroid hormone secretion in contrast to DIO3 playing role inactivation of the secretion. Activities of DIO1 and DIO2 play pivotal role in the negative feedback regulation of pituitary TSH secretion. L-Thyroxine (T4) and Triiodothyronine (T3) hormones are known to modulate the expression of ionic channels, pumps and regulatory contractile proteins. Moreover, thyroid hormones have been shown to influence calcium homeostasis and flux responsible for excitation and contractility, with L-Thyroxine and Triiodothyronine modulating its pharmacological control and secretion. In rats fed 12 weeks with the iodine-free diet, a significant decrease in the levels of both Triiodothyronine and L-Thyroxine is observed when compared to the control group fed with standard diet (p<0.001). In the group treated with low doses of L-Thyroxine, an increase in L-Thyroxine levels is observed (p=0.02) while Triiodothyronine levels remain virtually similar to the control group (p=0.19). Rats treated with high doses of L-Thyroxine display a significant increase in both Triiodothyronine and L-Thyroxine circulating concentrations compared to the non-treated hypothyroid group (p<0.001 and p=0.004, respectively) and a significant increase in L-Thyroxine levels when compared to the control values (p=0.03). |
危险品标志 | Xn - 有害物品 T - 有毒物品 F - 易燃物品 |
风险术语 | R40 - 少数报道有致癌后果。 R39/23/24/25 - R23/24/25 - 吸入、皮肤接触及吞食有毒。 R11 - 高度易燃。 |
安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 S36 - 穿戴适当的防护服。 S45 - 若发生事故或感不适,立即就医(可能的话,出示其标签)。 S36/37 - 穿戴适当的防护服和手套。 S16 - 远离火源。 |
危险品运输编号 | UN1230 - class 3 - PG 2 - Methanol, solution |
WGK Germany | 3 |
RTECS | YP2833500 |
FLUKA BRAND F CODES | 8-10 |
TSCA | Yes |
海关编号 | 29379000 |
Hazard Class | IRRITANT |
上游原料 | 氢氧化钠 一水硫酸锰 |
下游产品 | 左旋甲状腺素钠 |
参考资料 展开查看 | 1. 冯加华 卫克昭 许旭 等. 六味地黄丸对甲状腺素诱导阴虚证小鼠肝脏损伤的保护作用[J]. 上海中医药杂志 2019(11). 2. 范稣圳, 陶波, 刘浙波,等. 孕鼠甲状腺激素水平对胎鼠心肌细胞凋亡的影响研究[J]. 重庆医学, 2020(7):1036-1041. 3. Shan, Tong, et al. "Proteomics Based Mongolian Medicine Modified Sugmul-7 Mechanism of Regulating Endocrine Function in Hyperplasia of the Breast." Clinical Medicine Research 9.1 (2020): 11.doi: 10.11648/j.cmr.20200901.13 4. [IF=3.079] Nabi Ghulam et al."Circulating concentrations of thyroid hormones and cortisol in wild and semi-natural Yangtze finless porpoise (Neophocaena asiaeorientalis)."Conserv Physiol. 2021 Jan;9(1): |
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