中文名 | DKM 2-93 |
英文名 | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE |
别名 | 2-氯-N-((3 4-二甲氧苯基)甲基)乙酰胺 UBA5抑制剂(DKM 2-93) 2-氯-N-(3,4-二甲氧基苄基)乙酰胺 2-氯-N-((3,4-二甲氧苯基)甲基)乙酰胺 2-氯-N-[(3,4-二甲氧苯基)甲基]乙酰胺 乙酰胺,2-氯-N-((3,4-二甲氧苯基)甲基)- |
英文别名 | DKM 2-93 Brn 2857211 CHEMBRDG-BB 9070724 N-(Dimethoxy-3,4 benzyl)-chloroacetamide 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE 2-Chloro-N-((3,4-dimethoxyphenyl)methyl)acetamide N-(Dimethoxy-3,4 benzyl)-chloroacetamide [french] Acetamide, 2-chloro-N-((3,4-dimethoxyphenyl)methyl)- |
CAS | 65836-72-8 |
EINECS | 604-604-1 |
化学式 | C11H14ClNO3 |
分子量 | 243.69 |
密度 | 1.194±0.06 g/cm3(Predicted) |
熔点 | 116-118 °C(Solv: carbon tetrachloride (56-23-5)) |
沸点 | 425.7±45.0 °C(Predicted) |
酸度系数 | 13.42±0.46(Predicted) |
存储条件 | 2-8℃ |
体外研究 | Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC 50 s of 90 and 30 μM, respectively. |
体内研究 | DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity. |
危险品标志 | Xi - 刺激性物品 |
Hazard Class | IRRITANT |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 4.104 ml | 20.518 ml | 41.036 ml |
5 mM | 0.821 ml | 4.104 ml | 8.207 ml |
10 mM | 0.41 ml | 2.052 ml | 4.104 ml |
5 mM | 0.082 ml | 0.41 ml | 0.821 ml |
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