中文名 | BVT948 |
英文名 | 4-HYDROXY-3,3-DIMETHYL-2H-BENZO[G]INDOLE-2,5(3H)-DIONE |
别名 | 4-羟基-3,3-二甲基-2H-苯并[G]吲哚-2,5(3H)-二酮 |
英文别名 | BVT948 BVT 948 BVT-948(SPS8I-3) 4-HYDROXY-3,3-DIMETHYL-2H-BENZ[G]INDOLE-2,5(3H)-DIONE 4-HYDROXY-3,3-DIMETHYL-2H-BENZO[G]INDOLE-2,5(3H)-DIONE 2H-Benz[g]indole-2,5(3H)-dione, 4-hydroxy-3,3-dimethyl- |
CAS | 39674-97-0 |
化学式 | C14H11NO3 |
分子量 | 241.24 |
密度 | 1.39±0.1 g/cm3(Predicted) |
沸点 | 400.8±55.0 °C(Predicted) |
溶解度 | DMSO: 18 mg/mL |
酸度系数 | 5.78±0.40(Predicted) |
存储条件 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
外观 | 固体 |
颜色 | red |
体外研究 | Results show that the effect of BVT948 (BVT.948) is to strengthen the insulin signal and has no effects on the duration of the signal. BVT948 appears to be an effective inhibitor of both protein tyrosine phosphatases (PTP activity and P450 activity). BVT948 efficiently and selectively suppresses cellular H4 lysine 20 (H4K20me1) at doses lower than 5 μM within 24 h. The cells treated with BVT948 recapitulate cell-cycle-arrest phenotypes similar to what are reported for knocking down SETD8 by RNAi. Treatment of MCF-7 cells with 0.5, 1 or 5 μM of BVT948 for 24 h does not cause any significant changes in cell viability. BVT948 inhibits TPA-induced MMP-9 up-regulation in a dose-dependent manner. Treatment with BVT948 inhibits TPA-stimulated NF-κB binding activity, but not AP-1 binding activity. BVT948 does not affect the MAPK phosphorylation by TPA. Treatment with BVT948 diminishes the TPA-induced cell invasion by 50%. |
体内研究 | Results show that 3 μmol/kg BVT948 (BVT.948) significantly enhances glucose clearance from the blood stream in response to insulin compare with vehicle-treated controls. |
危险品标志 | Xi - 刺激性物品![]() |
风险术语 | 43 - 与皮肤接触可能致敏。 |
安全术语 | 36/37 - 穿戴适当的防护服和手套。 |
WGK Germany | 3 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 4.145 ml | 20.726 ml | 41.452 ml |
5 mM | 0.829 ml | 4.145 ml | 8.29 ml |
10 mM | 0.415 ml | 2.073 ml | 4.145 ml |
5 mM | 0.083 ml | 0.415 ml | 0.829 ml |