中文名 | 4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑鎓氯化物 |
英文名 | 4,5-Dimethyl-3-(2-oxo-2-phenyl)-chloride |
别名 | 阿拉氯胺 4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物 4,5-二甲基-3-(2-氧代-2-苯乙基)-噻唑氯化物 4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑鎓氯化物 4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑-3-鎓氯化物 4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物(ALT-711) |
英文别名 | ALT711 ALT-711 UNII-79QS8K2877 Alagebrium chloride (Alagebrium) (thiazolium salt) Dimethyl-3-(2-oxo-2-phenyl)-chloride 4,5-Dimethyl-3-(2-oxo-2-phenyl)-chloride 4,5-Dimethyl-3-(2-oxo-2-phenyl)-thiazoliumchloride 4,5-Dimethyl-3-(2-oxo-2-phenylethyl)thiazolium chloride Thiazolium, 4,5-dimethyl-3-(2-oxo-2-phenylethyl)-, chloride 2-(4,5-dimethyl-1,3-thiazol-3-yl)-1-phenyl-ethanone chloride 2-(4,5-dimethylthiazol-3-ium-3-yl)-1-phenyl-ethanone chloride 4,5-dimethyl-3-(2-oxo-2-phenylethyl)-1,3-thiazol-3-ium chloride 2-(4,5-dimethyl-1,3-thiazol-3-ium-3-yl)-1-phenylethanone chloride 2-(4,5-dimethyl-1,3-thiazol-3-ium-3-yl)-1-phenyl-ethanone chloride |
CAS | 341028-37-3 |
EINECS | 636-473-0 |
化学式 | C13H14ClNOS |
分子量 | 267.77 |
InChI | InChI=1/C13H14NOS.ClH/c1-10-11(2)16-9-14(10)8-13(15)12-6-4-3-5-7-12;/h3-7,9H,8H2,1-2H3;1H/q+1;/p-1 |
熔点 | 212 °C(dec.) |
溶解度 | DMSO (微溶) 、甲醇 (微溶) |
存储条件 | Hygroscopic, Refrigerator, under inert atmosphere |
外观 | 固体 |
颜色 | White to Off-White |
Merck | 14,203 |
体外研究 | Alagebrium chloride is an advanced glycation end product ( AGE ) inhibitor. Endothelial cell (EC) proliferation is increased for all groups receiving Alagebrium (ALT-711), particularly when seeded on matrix from the AAo of obese (ZO) and diabetic (ZD) rats. |
体内研究 | Blood pressure is not affected by treatment with Alagebrium. In diabetic RAGE apoE double-KO mice, treatment with Alagebrium is associated with a modest reduction in renal mass and reduces hyperfiltration compare with nontreated mice. Treatment with Alagebrium in diabetic RAGE apoE double-KO mice is associated with a further reduction in glomerular collagen IV levels, approaching levels observed in control mice. Body weight, heart rate (HR), and mean blood pressure (BP) are similar in Zucker lean (ZL), obese (ZO), and diabetic (ZD) groups in the absence or presence of Alagebrium (ALT-711). Alagebrium increases blood flow (BF) in ZO rats but reduces distal vascular resistance in ZD rats. A decrease in neointimal hyperplasia (NH) intrastrut thickness as a function of local radius is found in all groups with Alagebrium treatment. A significant increase in TGF-β expression is also found in the AAo of ZL rats treated with Alagebrium. |