中文名 | Galidesivir (BCX4430) |
英文名 | 3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, (2S,3S,4R,5R)- |
别名 | 加利司韦 加利西韦 化合物 T10491 |
英文别名 | Immucillin-A BCX4430 (freebase) Galidesivir (BCX4430) GALIDESIVIR (BCX 4430) BCX4430 freebase(Galidesivir) (2S,3S,4R,5R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)PYRROLIDINE-3,4-DIOL 3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, (2S,3S,4R,5R)- |
CAS | 249503-25-1 |
化学式 | C11H15N5O3 |
分子量 | 265.27 |
密度 | 1.630±0.06 g/cm3(Predicted) |
沸点 | 661.2±55.0 °C(Predicted) |
酸度系数 | 13.78±0.40(Predicted) |
存储条件 | 2-8℃ |
体外研究 | Cellular kinases phosphorylate Galidesivir (BCX4430) to a triphosphate that mimics ATP; viral RNA polymerases incorporate the drug's monophosphate nucleotide into the growing RNA chain, causing premature chain termination. Galidesivir effectively inhibits the infection of Vero cells with YFV. The EC50 determined by the neutral red uptake assay is 8.3 μg/ml (24.5 μM). |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.77 ml | 18.849 ml | 37.698 ml |
5 mM | 0.754 ml | 3.77 ml | 7.54 ml |
10 mM | 0.377 ml | 1.885 ml | 3.77 ml |
5 mM | 0.075 ml | 0.377 ml | 0.754 ml |
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