中文名 | 莫那比拉韦 |
英文名 | Uridine, 4-oxime, 5'-(2-methylpropanoate), (4Z)- |
别名 | 莫那匹韦 莫那比拉韦 莫努皮拉韦 莫那比拉韦对照品 莫匹拉韦标准品-QA 莫匹拉韦(EIDD 2801) ((2R,3S,4R,5R)-3,4-二羟基-5-((Z)-4-(肟基)-2-氧代-3,4-二氢嘧啶-1(2H)-基)四氢呋喃-2-基)甲基异丁酸酯 |
英文别名 | Molnupiravir-001-QA Uridine, 4-oxime, 5'-(2-methylpropanoate), (4Z)- |
CAS | 2492423-29-5 |
化学式 | C13H19N3O7 |
分子量 | 329.31 |
Molnupiravir (EIDD-2801) 是核糖核苷类似物 EIDD-1931 的口服生物可利用的异丙酯前药。Molnupiravir 显示出广泛的抗流感病毒 (influenza virus) 和coronaviruses的活性,如 SARS-CoV-2,MERS-CoV,SARS-CoV。Molnupiravir 有用于 COVID-19 和季节性,流行性流感的潜力。
莫努匹拉韦(EIDD-2801)是核糖核苷类似物EIDD-1931的口服生物可利用前药。莫努匹拉韦对流感病毒和多种冠状病毒具有广谱抗病毒活性,如严重急性呼吸系统综合征冠状病毒2型、严重急性呼吸综合征冠状病毒、严重急性呼吸道综合征冠状病毒。莫努皮拉韦在研究新冠肺炎、季节性流感和大流行性流感方面具有潜力
Molnupiravir (50-500 mg/kg; p.o.; every 12 hours for 3 days) is robustly antiviral and able to prevent SARS-CoV replication and disease.
Molnupiravir (7 mg/kg; p.o.; twice daily for 3.5 days) significantly reduces shed virus load and duration of fever.
Animal Model: | C57BL/6 mice (intranasal infection with SARS-CoV) |
Dosage: | 50, 150, 500 mg/kg |
Administration: | Oral; every 12 hours for 3 days |
Result: | Body weight loss is significantly diminished or prevented. |
Animal Model: | Ca/09-infected female ferrets |
Dosage: | 7 mg/kg |
Administration: | Oral; twice daily for 3.5 days |
Result: | Shed virus load and duration of fever were significantly reduced. |
微信搜索化工百科或扫描下方二维码,添加化工百科小程序,随时随地查信息!