中文名 | 27-羟基胆固醇 |
英文名 | 27-Hydroxycholesterol |
别名 | 胆固醇杂质31 27-羟基胆固醇 5,25R-胆甾烯-3BETA,26-二醇 |
英文别名 | 27-Hydroxycholesterol 25(R)-27-hydroxy Cholesterol cholest-(25R)-5-ene-3,27-diol 5,25R-Cholesten-3beta,26-diol (25R)-Cholest-5-en-3β,26β-diol (25R)-cholest-5-ene-3beta,26-diol 26-Hydroxycholesterol (not deuterated) 26-Hydroxycholesterol-26,26,27,27,27-D5 (3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-7-hydroxy-6-methyl-heptan-2-yl]-10,13-d |
CAS | 20380-11-4 |
化学式 | C27H46O2 |
分子量 | 402.65 |
密度 | 1.03 |
熔点 | 172-174 °C(Solv: hexane (110-54-3); ethyl acetate (141-78-6)) |
沸点 | 517.1±23.0 °C(Predicted) |
溶解度 | 溶于DMSO (高达10 mg/ml) 或乙醇 (高达10 mg/ml)。 |
酸度系数 | 15.03±0.70(Predicted) |
存储条件 | -20° |
稳定性 | 从提供的购买之日起稳定2年。在DMSO或乙醇中的溶液可以在-20 ° 储存长达2个月。 |
外观 | 白色固体。 |
颜色 | White |
MDL号 | MFCD00272990 |
体外研究 | 27-Hydroxycholesterol is an endogenous selective estrogen receptor modulator that displays significant partial agonist activity in a variety of cellular models of estrogen receptor action. It positively regulates both gene transcription and cell proliferation in cellular models of breast cancer. 27-Hydroxycholesterol, through estrogen receptor activation, triggers deleterious effect in prostate cancer cell lines. 27-Hydroxycholesterol significantly increases cell proliferation of LNCaP and PC3 cells and this effect can be attenuated by estrogen receptor inhibitors. 27-Hydroxycholesterol is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis. 27-Hydroxycholesterol also acts as an endogenous selective estrogen receptor modulator capable of increasing breast cancer growth and metastasis. 27-Hydroxycholesterol levels can be modulated by statins or direct inhibition of CYP27A1, thereby attenuating its pro-tumorigenic activities. 27-hydroxylation of cholesterol is an important pathway for LXR activation in response to cholesterol overload. |
参考资料 展开查看 | 1. 李昌达,史永军,林彦良.27-羟基胆固醇与胆固醇对裸鼠食管鳞癌和人食管癌细胞增殖的影响[J].山东大学学报(医学版),2020,58(11):45-52+58. 2. 李昌达. 胆固醇及27-羟基胆固醇在食管鳞癌增殖和转移的作用及机制研究[D].山东大学,2020. 3. 闻妩,黄家情,吕馨,蒋蒙蒙,贡岳松.二甲双胍对27-羟基胆固醇诱导的HT22细胞损伤的保护作用[J].神经解剖学杂志,2020,36(05):541-546. 4. [IF=5.546] Lishan Zhang et al."27‐Hydroxycholesterol enhanced osteoclastogenesis in lung adenocarcinoma microenvironment."J Cell Physiol. 2019 Aug;234(8):12692-12700 5. [IF=9.867] Li Xingkai et al."27-hydroxycholesterol linked high cholesterol diet to lung adenocarcinoma metastasis."Oncogene. 2022 Apr;:1-11 |