中文名 | 链脲霉素 |
英文名 | Streptozocin |
别名 | 链佐星 链氮霉素 链脲霉素 链脲菌素 链脲佐菌素 链脲佐菌素(脲激链霉素) 2-脱氧-2-(((甲基亚硝基氨基)羰基)-氨基)-D-吡喃葡萄糖 2-脱氧-2-[[(甲基亚硝基氨基)羰基]-氨基]-D-吡喃葡萄糖 2-脱氧-2-(((甲基亚硝基氨基)羰基)-氨基)-D-吡喃葡萄糖 |
英文别名 | STZ STR STREPTOZOCIN Streptozocin STREPTOZOTOCIN Streptozotocin Streptozotocin (U-9889) N-(METHYLNITROSOCARBAMOYL)-A-D-GLUCOSAMINE N-(METHYLNITROSOCARBAMOYL)-ALPHA-GLUCOSAMINE N-(METHYLNITROSOCARBAMOYL)-ALPHA-D-GLUCOSAMINE 2-desoxy-2-(3-methyl-3-nitrosoureido)-d-glucopyranose 2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)-d-glucose 2-deoxy-2-{[methyl(nitroso)carbamoyl]amino}-D-glucopyranose 2-deoxy-2-{[methyl(nitroso)carbamoyl]amino}-beta-D-glucopyranose 2-deoxy-2-{[methyl(nitroso)carbamoyl]amino}-alpha-D-glucopyranose (5xi)-2-deoxy-2-{[methyl(nitroso)carbamoyl]amino}-D-lyxo-hexopyranose |
CAS | 18883-66-4 |
EINECS | 242-646-8 |
化学式 | C8H15N3O7 |
分子量 | 265.22 |
InChI | InChI=1/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7-/m1/s1 |
InChIKey | ZSJLQEPLLKMAKR-FEQHFJGESA-N |
密度 | 1.4410 (rough estimate) |
熔点 | 121 °C (dec.) (lit.) |
沸点 | 408.44°C (rough estimate) |
比旋光度 | D25 +39° |
水溶性 | soluble |
溶解度 | 溶于DMSO (高达25毫克/毫升) 或水 (高达25毫克/毫升) |
折射率 | 1.6500 (estimate) |
酸度系数 | pKa 1.3 (Uncertain) |
存储条件 | -20°C |
稳定性 | 从提供的购买之日起稳定1年。DMSO或蒸馏水中的溶液可以在-20 °C下储存长达1个月。 |
敏感性 | Hygroscopic |
外观 | 粉末 |
颜色 | white to light yellow |
Merck | 13,8912 |
BRN | 2060675 |
物化性质 | 淡黄色结晶性粉末,易溶于水,但其水溶液在室温下极不稳定,可在半小时后分解为气体而挥发掉,故需现用现配。溶于较低度醇和酮,不溶于极性的有机溶剂。 |
MDL号 | MFCD00006607 |
体外研究 | Streptozotocin直接使DNA烷基化,并且具有很高的基因毒性,产生DNA链损伤,碱不稳定位点,期外DNA合成,DNA加合物,染色体畸变,微核,姐妹染色单体互换,以及细胞死亡。自由基参与DNA的合成并且染色体被Streptozotocin破坏。 |
体内研究 | Streptozotocin在动物实验中常被用于诱导糖尿病。Streptozotocin通过低亲和力的GLUT 2葡萄糖转运体在胰岛β细胞中选择性积累。Streptozotocin (60 毫克/千克)注射4个月会诱导β细胞快速脱粒而不坏死,白内障发展,以及糖原在肾脏的近曲小管中积累。在' Streptozotocin 糖尿病'大鼠体内,Streptozotocin (100 毫克/千克)使胰腺外分泌细胞产生损伤,使小的,可能分泌性的颗粒剂在β细胞的高尔基体中持续存在。 Streptozotocin在大鼠、小鼠和仓鼠体内被发现是致癌的。Streptozotocin单独给药能够在仓鼠的肾脏,肝脏,肺,胰腺以及子宫中诱发肿瘤。对血压正常的Wistar Kyoto大鼠(WKY)腹腔内注射Streptozotocin (100-150毫克/千克)12个月会诱发癌变,在肝脏中有70%的肿瘤发生率,肾脏中20%的肿瘤发生率,肝脏和肾脏同时病变有10%的可能性。 |
危险品标志 | Xn - 有害物品 T - 有毒物品 |
风险术语 | R40 - 少数报道有致癌后果。 R61 - 可能对胎儿造成伤害。 R46 - 可能引起遗传性基因损害。 R45 - 可能致癌。 R22 - 吞食有害。 R20/21/22 - 吸入、皮肤接触及吞食有害。 |
安全术语 | S36/37 - 穿戴适当的防护服和手套。 S53 - 避免接触,使用前须获得特别指示说明。 S45 - 若发生事故或感不适,立即就医(可能的话,出示其标签)。 S36 - 穿戴适当的防护服。 S22 - 切勿吸入粉尘。 |
危险品运输编号 | 3249 |
WGK Germany | 3 |
RTECS | LZ5775000 |
FLUKA BRAND F CODES | 3-10-21 |
海关编号 | 29419090 |
Hazard Class | 6.1(b) |
Packing Group | III |
参考资料 展开查看 | 1. 朱戈丽 伍军 张艳霞 等. miR-21介导PTEN/SMAD7信号传导通路调控糖尿病肾病大鼠肾纤维化作用研究[J]. 临床误诊误治 2020年33卷7期 104-108页 ISTIC 2020. 2. 周国佩 吴帆 朱金华 et al. 乌梅丸对2型糖尿病模型大鼠肠道菌群 炎性因子及短链脂肪酸的影响[J]. 中国实验方剂学杂志 2020(10). 3. 吉艳梅 文彩铃.六味地黄丸联合胰岛素对妊娠糖尿病大鼠血清皮质酮及胎盘11β-羟基类固醇脱氢酶表达的影响[J].解放军药学学报 2018 34(03):221-224+253. 4. 张文锦 方朝晖 赵媛媛 等. 启元胶囊对糖尿病模型大鼠周围神经病变干预机制[J]. 中医药临床杂志 2019 v.31(11):120-123. 5. 崔祥,尚尔鑫,江曙,钱大玮,段金廒.基于响应曲面法对黄芩-黄连配伍改善2型糖尿病糖脂代谢紊乱的相互作用研究[J].药学学报,2018,53(04):630-635. 6. 孙昕, 刘卫. 复方川芎滴丸对糖尿病肾病模型大鼠血液流变学及血气的影响[J]. 中国药房, 2017(7). 7. 杨文超, 顾正位, 路其康,等. 复方葛根片对糖尿病肾病模型大鼠肾组织的保护作用[J]. 中国药房, 2015(34). 8. 胡江, 缪菁, 段淑芳,等. 大黄酸对2型糖尿病模型大鼠的保护作用[J]. 中国药房, 2014, 025(023):2113-2116. 9. 汤陈鹏, 吕峰, 刘伊娜. 孔石莼多糖锌对Ⅰ型糖尿病小鼠糖脂代谢及体内抗氧化的干预作用[J]. 食品工业科技, 2020, v.41;No.441(01):301-306+315. 10. 伏瑶,周继栋,桑晓宇,孙笛洋,赵启韬,傅风华.瓜蒌薤白半夏汤对2型糖尿病合并急性心肌缺血大鼠造血干细胞的保护作用机制[J].中华中医药杂志,2020,35(05):2613-2617. 11. 王航利, 张梦迪, 黄绳武. 益气补阴方对气阴两虚证糖尿病大鼠的降血糖作用研究[J]. 中药新药与临床药理, 2020(8). 12. 王海生, 谢永财, 李长征,等. 石斛合剂对高脂高糖糖尿病大鼠心肌细胞Ca2+代谢的影响[J]. 福建中医药, 2020, 051(001):47-50. 13. 张哲滔,车念聪,郑亚琳,田甜,魏晓艺,刘晔.菖蒲郁金汤化裁方对2型糖尿病合并非酒精性脂肪肝大鼠SREBP-1c表达和胰岛素抵抗的影响[J].北京中医药,2019,38(01):17-20+97. 14. 袁利佳,张蕾,张晓东.蝙蝠蛾拟青霉菌粉对糖尿病模型大鼠的保护作用[J].食用菌学报,2018,25(02):99-104+167. 15. 李丽, 黄雪梦, 杨璐嘉,等. 采用2种降糖模型考察核桃蛋白及多肽的降糖作用[J]. 食品科技, 2017, 042(004):218-221. 16. 马可可,鞠营辉,陈清青,李维祖,李卫平.黄芪甲苷对2型糖尿病肾病大鼠肾组织PI3K/Akt/FoxO1信号调控的影响[J].中国实验方剂学杂志,2019,25(02):74-81. 17. 季天娇. 黄芪甲苷调节PI3K/Akt通路来改善2型糖尿病大鼠肝糖代谢异常的分子机制[D].安徽医科大学,2020. 18. 随风,时昭红.胰高血糖样肽1对非酒精性脂肪肝大鼠CFHR1~5表达的影响[J].中国免疫学杂志,2021,37(01):36-40. 19. 闫爽,李光耀,戴丛书,崔昊震,柳振宇,林长青.人参皂苷CK对2型糖尿病大鼠肝损伤的保护机制[J].食品工业科技,2021,42(02):310-315. 20. Li, Xiaopeng, et al. "Dietary supplementation of A-type procyanidins from litchi pericarp improves glucose homeostasis by modulating mTOR signaling and oxidative stress in diabetic ICR mice." Journal of Functional Foods 44 (2018): 155-165.https://doi.org/1 21. Jayachandran, Muthukumaran, et al. "Isoquercetin upregulates antioxidant genes, suppresses inflammatory cytokines and regulates AMPK pathway in streptozotocin-induced diabetic rats." Chemico-biological interactions 303 (2019): 62-69.https://doi.org/10.1016 22. Wei Xu, Qing Zhou, Jiao-jiao Yin, Yong Yao, Jiu-liang Zhang, Anti-diabetic effects of polysaccharides from Talinum triangulare in streptozotocin (STZ)-induced type 2 diabetic male mice, International Journal of Biological Macromolecules, Volume 72, 2015, P 23. Jayachandran, Muthukumaran, Ramachandran Vinayagam, and Baojun Xu. "Guava leaves extract ameliorates STZ induced diabetes mellitus via activation of PI3K/AKT signaling in skeletal muscle of rats." Molecular biology reports 47.4 (2020): 2793-2799. 24. Ding, Yue, et al. "Combination of honey with metformin enhances glucose metabolism and ameliorates hepatic and nephritic dysfunction in STZ-induced diabetic mice." Food & function 10.11 (2019): 7576-7587.https://doi.org/10.1039/C9FO01575B 25. Li, Xiaopeng, et al. "A-type procyanidins from litchi pericarp ameliorate hyperglycaemia by regulating hepatic and muscle glucose metabolism in streptozotocin (STZ)-induced diabetic mice fed with high fat diet." Journal of Functional Foods 27 (2016): 711-7 26. Li, Xiaopeng, et al. "Attenuated mTOR signaling and enhanced glucose homeostasis by dietary supplementation with lotus seedpod oligomeric procyanidins in streptozotocin (STZ)-induced diabetic mice." Journal of agricultural and food chemistry 65.19 (2017): 27. [IF=6.953] Wei Xu et al."Anti-diabetic effects of polysaccharides from Talinum triangulare in streptozotocin (STZ)-induced type 2 diabetic male mice."Int J Biol Macromol. 2015 Jan;72:575 28. [IF=6.529] Yinghui Ju et al."Protective effects of Astragaloside IV on endoplasmic reticulum stress-induced renal tubular epithelial cells apoptosis in type 2 diabetic nephropathy rats."Biomed Pharmacother. 2019 Jan;109:84 29. [IF=5.396] Xiaopeng Li et al."(−)-Epigallocatechin-3-gallate (EGCG) inhibits starch digestion and improves glucose homeostasis through direct or indirect activation of PXR/CAR-mediated phase II metabolism in diabetic mice."Food Funct. 2018 Sep;9(9):4651-4663 30. [IF=4.451] Xiaopeng Li et al."Dietary supplementation of A-type procyanidins from litchi pericarp improves glucose homeostasis by modulating mTOR signaling and oxidative stress in diabetic ICR mice."J Funct Foods. 2018 May;44:155 31. [IF=4.192] Xiaopeng Li et al."Attenuated mTOR Signaling and Enhanced Glucose Homeostasis by Dietary Supplementation with Lotus Seedpod Oligomeric Procyanidins in Streptozotocin (STZ)-Induced Diabetic Mice."J Agr Food Chem. 2017;65(19):3801–3810 32. [IF=3.701] Xiaopeng Li et al."A-type procyanidins from litchi pericarp ameliorate hyperglycaemia by regulating hepatic and muscle glucose metabolism in streptozotocin (STZ)-induced diabetic mice fed with high fat diet."J Funct Foods. 2016 Dec;27:711 33. [IF=1.902] Yukun Feng et al."Validated LC-MS method for simultaneous quantitation of catalpol and harpagide in rat plasma: application to a comparative pharmacokinetic study in normal and diabetic rats after oral administration of Zeng-Ye-Decoction."Biomed Chromatog 34. [IF=5.396] Xiaopeng Li et al."Diabetes diminishes a typical metabolite of litchi pericarp oligomeric procyanidins (LPOPC) in urine mediated by imbalanced gut microbiota."Food Funct. 2021 Jun;12(12):5375-5386 35. [IF=5.396] Jun-ping Liu et al."Antidiabetic activities of glycoprotein from pea (Pisum sativum L.) in STZ-induced diabetic mice."Food Funct. 2021 Jun;12(11):5087-5095 36. [IF=5.396] Yue Ding et al."Combination of honey with metformin enhances glucose metabolism and ameliorates hepatic and nephritic dysfunction in STZ-induced diabetic mice."Food Funct. 2019 Nov;10(11):7576-7587 37. [IF=5.037] Mengyuan Fang et al."Asiatic acid attenuates diabetic retinopathy through TLR4/MyD88/NF-κB p65 mediated modulation of microglia polarization."Life Sci. 2021 Jul;277:119567 38. [IF=4.545] Zhongyuan Wang et al."Protective effects of AS-IV on diabetic cardiomyopathy by improving myocardial lipid metabolism in rat models of T2DM."Biomed Pharmacother. 2020 Jul;127:110081 39. [IF=4.219] Zhenlong Qin et al."Analysis of the analgesic effects of tricyclic antidepressants on neuropathic pain, diabetic neuropathic pain, and fibromyalgia in rat models."Saudi J Biol Sci. 2020 Sep;27:2485 40. [IF=2.952] Yunfeng Zhu et al."Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy."Mol Med Rep. 2021 Jun;23(6):1-12 41. [IF=1.779] Shan-Na Chen et al."Protective effect of LIF-huMSCs on the retina of diabetic model rats."Int J Ophthalmol-Chi. 2021; 14(10): 1508–1517 42. [IF=6.843] Shilu Ji et al."An oxygen-sensitive probe and a hydrogel for optical imaging and photodynamic antimicrobial chemotherapy of chronic wounds."Biomater Sci-Uk. 2022 Apr;10(8):2054-2061 43. [IF=9.381] Yuanping Hao et al."Carboxymethyl chitosan-based hydrogels containing fibroblast growth factors for triggering diabetic wound healing."Carbohyd Polym. 2022 Jul;287:119336 44. [IF=6.953] Qian Liao et al."Characterization and diabetic wound healing benefits of protein-polysaccharide complexes isolated from an animal ethno-medicine Periplaneta americana L.."Int J Biol Macromol. 2022 Jan;195:466 45. [IF=6.953] Lan Pang et al."Two glycoproteins from medicinal insect Periplaneta americana (L.) promote diabetic wound healing via macrophage polarization modulation."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2022 Jun;209:2130 46. [IF=3.639] Min Liu et al."Peanut Skin Procyanidins Ameliorates Insulin resistance via Modulation of Gut Microbiota and Gut Barrier in Type 2 Diabetic Mice."JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE |