中文名 | Dichlorophenyl-ABA |
英文名 | Dichlorophenyl-ABA |
别名 | 化合物 T15116 |
英文别名 | Dichlorophenyl-ABA benzoic acid, 2-[(3,5-dichlorophenyl)amino]- |
CAS | 18201-65-5 |
化学式 | C13H9Cl2NO2 |
分子量 | 282.12 |
密度 | 1.470±0.06 g/cm3(Predicted) |
熔点 | 245 °C |
沸点 | 420.8±45.0 °C(Predicted) |
溶解度 | DMSO: ~ 18毫克/毫升,在 ~ 60 °C |
酸度系数 | 3.62±0.36(Predicted) |
存储条件 | 2-8°C |
外观 | 固体 |
颜色 | white |
体外研究 | Dichlorophenyl-ABA (DCPA) is able to prevent L55P aggregate formation in the conditioned medium. With regard to the ultrastructural analysis, Dichlorophenyl-ABA does not show an inhibitory effect as high as DFPB and benzoxazole, indicating that the Y78F mutant may not be as sensitive to this drug as TTR L55P and V30M are. Dichlorophenyl-ABA is the best stabilizers of V30M tetramers in plasma from carriers of this mutant, and clearly inhibit aggregation in the cellular system. Therefore Dichlorophenyl-ABA is promising for the treatment of valine at position 30 (V30M)-associated familial amyloidotic polyneuropathy (FAP) but need to undergo further stages of drug development to overcome their toxicity. |
危险品标志 | Xi - 刺激性物品 |
风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。 |
WGK Germany | 3 |