中文名 | 17α-雌二醇 |
英文名 | 17α-Estradiol |
别名 | 表雌二醇 17Α-雌二醇 17α-雌二醇 alpha-雌二醇 炔雌醇杂质L(EP) 17-ALPHA-雌二醇 1,3,5(10)雌甾三烯-3,17Α-二醇 3,17Α-二羟基-1,3,5(10)雌甾三烯 雌甾-1,3,5(10)三烯-3,17Α-二醇 |
英文别名 | epiestradial 17α-Estradiol 17alpha-Oestradiol 1,3,5-Estratriene-3,17alpha-diol 1,3,5-estratriene-3,17-alpha-diol 5(10)-triene-3,17-diol,(17-alpha)-estra-3 3,17alpha-Dihydroxyestra-1,3,5(10)-triene 3,17alpha-Dihydroxyoestra-1,3,5(10)-triene 3,17-alpha-dihydroxyoestra-1,3,5(10)-triene |
CAS | 57-91-0 |
EINECS | 200-354-8 |
化学式 | C18H24O2 |
分子量 | 272.39 |
密度 | 1.0708 (rough estimate) |
熔点 | 176-180°C(lit.) |
沸点 | 355.44°C (rough estimate) |
比旋光度 | D20 +53 to +56° (c = 0.9 in dioxane) |
水溶性 | 3.9mg/L(25 ºC) |
溶解度 | 乙醇: 50毫克/毫升,澄清,无色 |
折射率 | 1.4800 (estimate) |
酸度系数 | 10.27±0.60(Predicted) |
存储条件 | Sealed in dry,Room Temperature |
外观 | 粉末 |
颜色 | white with slight yellow cast |
Merck | 14,3704 |
体外研究 | Alpha-Estradiol (17 alpha-Estradiol) is a 5α-reductase inhibitor, and inhibits testosterone metabolism catalyzed by 5 alpha-reductase. Alpha-Estradiol (17 Alpha-estradiol, 10 μM) attenuates LPS-induced inflammatory markers in both C57BL/6J male and female mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes and differentiated 3T3-L1 adipocytes in an ERα-dependent manner, and such effects are through decreased NFκB-p65 and increased ERα protein expression. |
体内研究 | Alpha-Estradiol (17-alpha-estradiol, 0.01, 0.1, 1 μg) significantly reduces the percentage of central avascular/total retina area of the mouse pups. Alpha-Estradiol (1 μg) markedly decreasesmalondialdehyde (MDA) levels on postnatal days (PND) 9, 13, and 17 in retinas of hyperoxia-exposed pups. Alpha-Estradiol (1 μg) also decreases the number of NADPH-oxidase-positive cells, NADPH oxidase concentration and activity in retinas of the pups. In the 1.0-μg Alpha-Estradiol-treated pups, VEGF retinal concentrations are high on PND 9 but lower on PND 14 and 17. The best effect in retinas of 1.0-μg Alpha-Estradiol-treated pups is partly reversed by ICI182780 on PND 14 and 17. |
危险品标志 | T - 有毒物品 Xn - 有害物品 |
风险术语 | R45 - 可能致癌。 R48 - 长期接触严重危害健康。 R40 - 少数报道有致癌后果。 |
安全术语 | S53 - 避免接触,使用前须获得特别指示说明。 S45 - 若发生事故或感不适,立即就医(可能的话,出示其标签)。 S24/25 - 避免与皮肤和眼睛接触。 S22 - 切勿吸入粉尘。 |
危险品运输编号 | UN 2811 6.1/PG 2 |
WGK Germany | 3 |
RTECS | KG3750000 |
FLUKA BRAND F CODES | 8-10 |
海关编号 | 29372390 |
上游原料 | 17ALFA-双氢马烯雌酮 |
参考资料 展开查看 | 1. 张俊杰, 胡琼, 管潇萌,等. 白斑狗鱼雌性化诱导和雌雄同体现象[J]. 水产学报, 2018. 2. Xu, Minhua, et al. "Chronic restraint stress induces excessive activation of primordial follicles in mice ovaries." PLoS One 13.3 (2018): e0194894.https://doi.org/10.1371/journal.pone.0194894 |