中文名 | 6-甲酰基吲哚并[3,2-B]咔唑 |
英文名 | 6-ForMylindolo[3,2-b]carbazole |
别名 | 化合物FICZ 吲哚并[3,2-B]咔唑-6-甲醛 6-甲酰基吲哚并[3,2-B]咔唑 6-甲酰基-5,11-二氢吲哚并[3,2-B]咔唑 |
英文别名 | FICZ 6-FORMYLINDOLO A CARBAZOLE 6-ForMylindolo[3,2-b]carbazole 6-FORMYLINDOLO [3,2-B] CARBAZOLE Indolo[3,2-b]carbazole-6-carbaldehyde 5H,11H-indolo[3,2-b]carbazole-6-carbaldehyde 5,11-dihydroindolo[3,2-b]carbazole-6-carbaldehyde 5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde Indolo[3,2-b]carbazole-6-carboxaldehyde, 5,11-dihydro- |
CAS | 172922-91-7 |
化学式 | C19H12N2O |
分子量 | 284.31 |
密度 | 1.463±0.06 g/cm3(Predicted) |
沸点 | 630.3±35.0 °C(Predicted) |
溶解度 | 溶于DMSO (高达10 mg/ml)。 |
酸度系数 | 15.66±0.30(Predicted) |
存储条件 | -20°C |
稳定性 | 从提供的购买之日起稳定1年。DMSO中的溶液可以在-20 ° 下储存长达1个月。 |
外观 | 粉末 |
颜色 | yellow to orange |
物化性质 | 生物活性 FICZ (6-Formylindolo[3,2-b]carbazole) 是一种 aryl hydrocarbon receptor (AhR) 的有效激动剂,可被AHR调节的细胞色素P4501酶有效地代谢。 |
体外研究 | FICZ (0.01 nM-1 µM) alone or in combination with 50 nM MNF induces sustained CYP1A1 activity and leads to oxidative stress and activation of apoptosis via a mitochondrial-dependent pathway. In HepG2 cells, FICZ stimulates cell growth at low concentrations but inhibits cell growth at high concentrations. FICZ (10,000-30,000 nM) significantly decreases CEH viability with an estimated LC 50 (95% confidence intervals) of 14,000 nM. FICZ shows concentration-dependent effects on EROD activity in CEH cultures, with the mean EC 50 values at 3, 8, and 24 h of 0.016 nM, 0.80 nM, and 11 nM, respectively. FICZ treatment increases transcript expression of CYP1A1 in a dose-dependent manner in both the parental iPSC line and the CYP1A1 targeted clone. CYP1 inhibition in the presence of FICZ results in enhanced AHR activation, suggesting that FICZ accumulates in the cell when its metabolism is blocked. CYP1 enzymes plays a role in regulating biological effects of FICZ. Nuclear export and degradation of the AHR protein are two additional steps in the AHR-mediated signal transduction pathway. Exposure to AhR agonists causes AhR-expressing cells to downregulate the receptor through the ubiquitin/proteasome degradation pathway. |
WGK Germany | 1 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.542 ml | 17.712 ml | 35.424 ml |
5 mM | 0.708 ml | 3.542 ml | 7.085 ml |
10 mM | 0.354 ml | 1.771 ml | 3.542 ml |
5 mM | 0.071 ml | 0.354 ml | 0.708 ml |