中文名 | 夫雷非班 |
英文名 | Fradafiban |
别名 | 夫雷非班 |
英文别名 | BIBU-52 Fradafiban 3-Pyrrolidineacetic acid, 5-[[[4'-(aminoiminomethyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-2-oxo-, (3S,5S)- |
CAS | 148396-36-5 |
化学式 | C20H21N3O4 |
分子量 | 367.403 |
密度 | 1.38±0.1 g/cm3(Predicted) |
酸度系数 | 4.29±0.10(Predicted) |
体外研究 | Fradafiban is a nonpeptide mimetic of the arginine-glycine-aspartic acid recognition sequence. Fradafiban binds with high affinity and selectivity to the human platelet GP IIb/IIIa complex and potently inhibits human platelet aggregation in vitro. Fradafiban reversibly binds to the human platelet GP IIb/IIIa complex with a K d value of 148 nM. |
体内研究 | Fradafiban has only very limited oral activity probably due to its high polarity and thus poor absorption after oral ingestion. |