中文名 | PNU-282987 |
英文名 | N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE |
别名 | PNU-282987盐酸盐 N-(3R)-1-氮杂双环[2,2,2]辛-3-基-4-氯苯甲酰胺盐酸盐 |
英文别名 | CS-1012 PNU 282987 PNU-282987 PNU282987 HCl PNU 282987(PNU 282987 hydrochloride) N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide hydrochloride N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide hydrochloride PNU 282987 |
CAS | 123464-89-1 |
化学式 | C14H17ClN2O |
分子量 | 264.75058 |
熔点 | 240-242℃ |
溶解度 | 溶于DMSO (高达25 mg/ml) |
存储条件 | Inert atmosphere,2-8°C |
稳定性 | 从提供的购买之日起稳定1年。DMSO中的溶液可以在-20 °C下储存长达2个月。 |
外观 | 灰白色固体 |
颜色 | White |
参考资料 展开查看 | 1: Navarro E, Gonzalez-Lafuente L, Perez-Liebana I, Buendia I, López-Bernardo E, Sanchez-Ramos C, Prieto I, Cuadrado A, Satrustegui J, Cadenas S, Monsalve M, Lopez MG. Heme-oxygenase I and PCG-1α regulate mitochondrial biogenesis via microglial activation of alpha7 nicotinic acetylcholine receptors using PNU282987. Antioxid Redox Signal. 2016 Aug 23. [Epub ahead of print] PubMed PMID: 27554853. 2: Marcus MM, Björkholm C, Malmerfelt A, Möller A, Påhlsson N, Konradsson-Geuken Å, Feltmann K, Jardemark K, Schilström B, Svensson TH. Alpha7 nicotinic acetylcholine receptor agonists and PAMs as adjunctive treatment in schizophrenia. An experimental study. Eur Neuropsychopharmacol. 2016 Sep;26(9):1401-11. doi: 10.1016/j.euroneuro.2016.07.004. Epub 2016 Jul 26. PubMed PMID: 27474687. 3: Zhang Y, Cao SX, Sun P, He HY, Yang CH, Chen XJ, Shen CJ, Wang XD, Chen Z, Berg DK, Duan S, Li XM. Loss of MeCP2 in cholinergic neurons causes part of RTT-like phenotypes via α7 receptor in hippocampus. Cell Res. 2016 Jun;26(6):728-42. doi: 10.1038/cr.2016.48. Epub 2016 Apr 22. PubMed PMID: 27103432; PubMed Central PMCID: PMC4897179. 4: Fan BS, Zhang EH, Wu M, Guo JM, Su DF, Liu X, Yu JG. Activation of α7 Nicotinic Acetylcholine Receptor Decreases On-site Mortality in Crush Syndrome through Insulin Signaling-Na/K-ATPase Pathway. Front Pharmacol. 2016 Mar 29;7:79. doi: 10.3389/fphar.2016.00079. eCollection 2016. PubMed PMID: 27065867; PubMed Central PMCID: PMC4810156. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.777 ml | 18.886 ml | 37.771 ml |
5 mM | 0.755 ml | 3.777 ml | 7.554 ml |
10 mM | 0.378 ml | 1.889 ml | 3.777 ml |
5 mM | 0.076 ml | 0.378 ml | 0.755 ml |