中文名 | Englerin A |
英文名 | Englerin A |
别名 | 恩格林A |
英文别名 | Englerin A (?)-Englerin A (-)-ENGLERIN A Englerin A high purity (1S,2R,5R,6R,7S,8R,10R)-10-(Glycoloyloxy)-8-isopropyl-1,5-dimethyl-11-oxatricyclo[6.2.1.02,6]undec-7-yl(2E)-3-phenylacrylate (1S,2R,5R,6R,7S,8R,10R)-10-(GLYCOLOYLOXY)-8-ISOPROPYL-1,5-DIMETHYL-11-OXATRICYCLO[6.2.1.02,6]UNDEC-7-YL (2E)-3-PHENYLACRYLATE 2-Propenoic acid, 3-phenyl-, (1R,3aR,4S,5R,7R,8S,8aR)-decahydro-5-[(2-hydroxyacetyl)oxy]-1,4-dimethyl-7-(1-methylethyl)-4,7-epoxyazulen-8-yl ester, (2E)- |
CAS | 1094250-15-3 |
化学式 | C26H34O6 |
分子量 | 442.54 |
存储条件 | Room Temprature |
体外研究 | Englerin A (0.15-2500 nM; 48 h) characteristic concentration-dependent suppresses cells growth of the A-498 cells treated with the control siRNA while has little effect on the growth of cells treated with TRPC4 siRNAs. Englerin A (0.001nM-10 μM; 48 h) inhibits cells viability in HEK293T cells overexpressing TRPC5. Englerin A (3 nM; 1-240 s) evokes sustained elevation of the intracellular Ca 2+ concentration within 1 min in HEK 293 cells over-expressing human TRPC4. Englerin A (0.1-1000 nM; 1-300 s) evokes intracellular Ca 2+ elevations in A498 cells as well with an EC 50 of 10 nM. |
体内研究 | Englerin A (5 mg/kg; i.p daily except Sunday) markedly inhibits tumor growth during the 2-week treatment period in mice. |