中文名 | GSK 4716 |
英文名 | 4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE |
别名 | 化合物GSK-4716 (E)-4-羟基-N'-(4-异丙基亚苄基)苯并酰肼 4-羟基苯甲酸 2-[[4-(1-甲基乙基)苯基]亚甲基]肼 |
英文别名 | CS-1084 GSK 4716 4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide (E)-4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide 4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE 2-[[4-(1-Methylethyl)phenyl]methylene]hydrazide 4-hydroxybenzoic acid 4-Hydroxybenzoic acid 2-[[4-(1-methylethyl)phenyl]methylene]hydrazide Benzoic acid, 4-hydroxy-, 2-[[4-(1-methylethyl)phenyl]methylene]hydrazide |
CAS | 101574-65-6 |
化学式 | C17H18N2O2 |
分子量 | 282.34 |
密度 | 1.12 |
溶解度 | DMSO: >10 mg/mL |
酸度系数 | 8.48±0.15(Predicted) |
存储条件 | Inert atmosphere,2-8°C |
外观 | 粉末 |
颜色 | white to off-white |
体外研究 | Treatment of differentiated C2C12 cells with the ERRβ/γ agonist (relative to vehicle) over a 2 to 4 h time period reveals a reproducible and robust increase in the immunoreactivity of the GRα-D isoform. It is observed that MAO-A mRNA expression is significantly increased by treatment with the ERRβ/γ agonist, GSK4716. Furthermore, it is observed that GSK4716 induces the expression of the mRNAs encoding peroxisome proliferator-activated receptor-γcoactivator 1α (PGC-1α) and PGC-1β (key regulator of many metabolic genes) identified as direct coactivators for the ERR family. GSK4716 induces the expression of PGC-1 and genes involved in fatty acid oxidation in concordance with the characterized role of ERRγ in cardiac metabolism. Treatment of primary mouse myotubes with GSK4716, an ERRβ/γ agonist, results in a concerted increase in the expression levels of Ppargc1a , Ppargc1b , and the Esrr genes. Furthermore, Cpt1b , Atp5b , and Idh3 , genes in key mitochondrial pathways, are also induced by GSK4716. Additionally, GSK4716 increases citrate synthase activity and cytochrome c protein levels. |
危险品标志 | Xi - 刺激性物品 N - 危害环境的物品 |
风险术语 | R43 - 与皮肤接触可能致敏。 R50/53 - 对水生生物有极高毒性,可能对水体环境产生长期不良影响。 |
安全术语 | S36/37 - 穿戴适当的防护服和手套。 S60 - 该物质及其容器须作为危险性废料处置。 S61 - 避免释放至环境中。参考特别说明/安全数据说明书。 |
危险品运输编号 | UN 3077 9 / PGIII |
WGK Germany | 3 |
Hazard Class | 9 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.542 ml | 17.709 ml | 35.418 ml |
5 mM | 0.708 ml | 3.542 ml | 7.084 ml |
10 mM | 0.354 ml | 1.771 ml | 3.542 ml |
5 mM | 0.071 ml | 0.354 ml | 0.708 ml |