(4-methoxyphenyl)-morpholin-4-yl-sulfanylidene-sulfido-λ5-phosphane,morpholin-4-ium
GYY 4137 MORPHOLINE SALT(GYY 4137 Morpholine salt)
CAS: 106740-09-4
化学式: C15H25N2O3PS2
| 中文名 | GYY 4137 MORPHOLINE SALT |
| 英文名 | GYY 4137 Morpholine salt |
| 别名 | 4-甲氧基苯基硫代磷酸酯(吗啉)吗啉盐 (4-甲氧基苯基)吗啉基-二硫代膦酸与吗啉的化合物 化合物GYY 4137 MORPHOLINE SALT 4-甲氧基苯基硫代磷酸酯(吗啉)吗啉盐 4-METHOXYPHENYL(MORPHOLINO)PHOSPHINODITHIOATE MORPHOLINIUM SALT |
| 英文别名 | GYY4137 GYY 4137 GYY-4137 GYY 4137 MORPHOLINE SALT GYY 4137 Morpholine salt morpholin-4-ium (4-methoxyphenyl)(morpholino)phosphinodithioate 4-Methoxyphenyl(morpholino)phosphinodithioate morpholinium salt P-(4-Methoxyphenyl)-P-4-morpholinylphosphinodithioic acid morpholine salt (4-Methoxyphenyl)morpholino-phosphinodithioic acid compound with morpholine (4-methoxyphenyl)-morpholin-4-yl-sulfanylidene-sulfido-λ5-phosphane,morpholin-4-ium |
| CAS | 106740-09-4 |
| 化学式 | C15H25N2O3PS2 |
| 分子量 | 376.474361 |
| 熔点 | 164-166℃ |
| 存储条件 | 2-8℃ |
| 外观 | 白色固体。 |
| 体外研究 | GYY4137 (400-800 µM) causes concentration-dependent killing of seven different human cancer cell lines (HeLa, HCT-116, Hep G2, HL-60, MCF-7, MV4-11 and U2OS) but did not affect survival of normal human lung fibroblasts (IMR90, WI-38). GYY4137 (0.1-0.5 mM) decreases LPS-induced production of nitrite (NO2−), PGE2, TNF-α and IL-6 from human synoviocytes (HFLS) and articular chondrocytes (HAC), reduces the levels and catalytic activity of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and reduced LPS-induced NF-κB activation. Cell Viability Assay Cell Line: HeLa, HCT-116, Hep G2, HL-60, MCF-7, MV4-11 and U2OS Concentration: 400 or 800 µM Incubation Time: 5 days Result: Significantly affected cancer cell survivability. |
| 体内研究 | GYY4137 (100-300 mg/kg; i.p.; daily for 14 days) significantly reduces the tumor volume in both animal models, in a dose-dependent manner. In the complete Freund's adjuvant (CFA)-treated mouse, GYY4137 (50 mg/kg, i.p.) injected 1 hr prior to CFA increased knee joint swelling while an anti-inflammatory effect, as demonstrated by reduced synovial fluid myeloperoxidase (MPO) and N-acetyl-β-D-glucosaminidase (NAG) activity and decreased TNF-α, IL-1β, IL-6 and IL-8 concentration, was apparent when GYY4137 was injected 6 hrs after CFA. GYY4137 significantly inhibited tumor growth in the subcutaneous HepG2 xenograft model by inhibiting STAT3 activation and its target gene expression. GYY4137 prevents nitrative stress and α-synuclein nitration in an MPTP mouse model of parkinson’s disease. Animal Model: Female, severe combined immunodeficiency (SCID) mice (bearing HL-60 or MV4-11 cells) Dosage: 100, 200 and 300 mg/kg Administration: I.p.; daily for 14 days Result: Reduced tumor volume by 52.5±9.2% and 55.3±5.7% in HL-60 and MV4–11 injected animals. |
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产品名: GYY 4137 MORPHOLINE SALT 去供应商网站查看 询盘CAS: 106740-09-4
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包装: 100 mg
价格: $439
库存: In stock
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产品名: GYY4137 morpholine salt 去供应商网站查看 询盘CAS: 106740-09-4
产地: 上海
规格: G795739
价格: 1ml-688,10mg-988,100mg-4488
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产品名: GYY 4137 MORPHOLINE SALT 去供应商网站查看 询盘
CAS: 106740-09-4
产地: 上海
规格: 98%
价格: 10mg 3370
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产品描述: GYY 4137 MORPHOLINE SALT 98% 源叶 货号：T21563
CAS: 106740-09-4
产地: 上海
规格: 98%
价格: 10mg 3370
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: GYY 4137 MORPHOLINE SALT 98% 源叶 货号：T21563
现货供应
产品名: GYY 4137 MORPHOLINE SALT 去供应商网站查看 询盘CAS: 106740-09-4
产地: 其他
包装: 100 mg
价格: $439
库存: In stock
电话: +16314854226
手机: +16314854226
电子邮件: info@bocsci.com
产品描述: GYY-4137 Morpholine salt is a novel water-soluble and slow releasing Hydrogen su 更多
产品目录: 点此进入
现货供应
产品名: GYY4137 morpholine salt 去供应商网站查看 询盘CAS: 106740-09-4
产地: 上海
规格: G795739
价格: 1ml-688,10mg-988,100mg-4488
库存: 现货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2881510266
微信: 19863730987/17821173903
产品名: GYY 4137 MORPHOLINE SALT 去供应商网站查看 询盘
CAS: 106740-09-4
产地: 上海
规格: 98%
价格: 10mg 3370
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: GYY 4137 MORPHOLINE SALT 98% 源叶 货号：T21563
CAS: 106740-09-4
产地: 上海
规格: 98%
价格: 10mg 3370
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: GYY 4137 MORPHOLINE SALT 98% 源叶 货号：T21563
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