中文名 | 表阿霉素 |
英文名 | Epirubicin |
别名 | 表比星 表阿霉素 表柔吡星 表阿霉霉 表柔比星 EPI-多柔比星 表柔比星(表阿霉素) 10-[(3-氨基-2,3,6-三脱氧-Α-L-阿式-己吡喃糖基)氧]-7,8,9,10-四氢-6,8,11-三羟基-8-(羟乙酰基)-甲氧基-(8S-CIS)-并四苯-5,12-二酮 |
英文别名 | WP 697 NSC 256942 Epirubicin Pidorubicin Farmarubicin Farmarubicine Pharmarubicin Epidoxorubicin 10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-(8s-)oxy)-9 |
CAS | 56420-45-2 |
化学式 | C27H29NO11 |
分子量 | 543.52 |
InChI | InChI=1/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15+,17-,22-,27?/m1/s1 |
密度 | 1.3783 (rough estimate) |
沸点 | 617.77°C (rough estimate) |
折射率 | 1.6400 (estimate) |
酸度系数 | 7.35±0.60(Predicted) |
存储条件 | -20°C |
物化性质 | 盐酸表柔比星(Epirubicin Hydrochloride):C27H29 NO11?HCI。[56390-09-1]。橘红色结晶,熔点185℃(分解)。 [α]D20+274°(C=0.01,甲醇)。溶液应避光保存。 |
上游原料 | 三氟乙酸酐 乙酸钾 盐酸柔红霉素 氯铬酸吡啶盐(PCC) 对甲苯磺酸 |
参考资料 展开查看 | 1. [IF=9.867] Sun Huiying et al."CRIP1 cooperates with BRCA2 to drive the nuclear enrichment of RAD51 and to facilitate homologous repair upon DNA damage induced by chemotherapy."Oncogene. 2021 Jul;40(34):5342-5355 2. [IF=4.384] Wenxin Pei et al."High payload and targeted release of anthracyclines by aptamer-tethered DNA nanotrains — Thermodynamic and release kinetic study."Eur J Pharm Sci. 2020 May;148:105319 3. [IF=4.098] Qingying Guo et al."Spectroscopic and cytotoxicity studies on the combined interaction of (−)-epigallocatechin-3-gallate and anthracycline drugs with human serum albumin."Spectrochim Acta A. 2019 Nov;222:117213 |
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