中文名 | 呋喃菲林 |
英文名 | furafylline |
别名 | 呋喃菲林 呋拉茶碱 呋喃茶碱 3-(呋喃-2-基甲基)-1,8-二甲基-1H-嘌呤-2,6(3H,7H)-二酮 |
英文别名 | FURAFYLLINE furafylline FURAFYLLINE INHIBITOR OF CYTOCHRO 3-(Furan-2-ylmethyl)-1,8-dimethyl-1H-purine-2,6(3H,7H)-dione 3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE 1H-Purine-2,6-dione, 3-(2-furanylmethyl)-3,9-dihydro-1,8-dimethyl- Furafylline,3-(2-Furanylmethyl)-3,7-dihydro-1,8-dimethyl-1H-purine-2,6-dione |
CAS | 80288-49-9 |
EINECS | 200-158-5 |
化学式 | C12H12N4O3 |
分子量 | 260.25 |
InChI | InChI=1/C12H12N4O3/c1-2-7-19-10-5-3-9(4-6-10)12-13-15-16(14-12)8-11(17)18/h2-6H,1,7-8H2,(H,17,18) |
InChIKey | KGQZGCIVHYLPBH-UHFFFAOYSA-N |
密度 | 1.443±0.06 g/cm3(Predicted) |
熔点 | >162°C (dec.) |
沸点 | 543.6±60.0 °C(Predicted) |
闪点 | 259.1°C |
蒸汽压 | 5.16E-11mmHg at 25°C |
溶解度 | 乙醇: 0.33mg/ml |
折射率 | 1.627 |
酸度系数 | 8.62±0.70(Predicted) |
存储条件 | 2-8°C(protect from light) |
外观 | 固体 |
颜色 | white |
体内研究 | Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC 50 of 0.07 μM in kinase experiment. Furafylline is a methylxanthine derivative that is introduced as a long-acting replacement for theophylline in the treatment of asthma. Administration of Furafylline is associated with an elevation in plasma levels of caffeine, due to inhibition of caffeine oxidation, a reaction catalysed by one or more hydrocarbon-inducible isoenzymes of P450. Furafylline has either very little or no effect on human monooxygenase activities catalysed by other isoenzymes of P450, including P4501ID1, P4501IC, P450IIIA. |
WGK Germany | 3 |
参考资料 展开查看 | 1. [IF=8.071] Xia Lv et al.Regioselective hydroxylation of carbendazim by mammalian cytochrome P450: A combined experimental and computational study.Environ Pollut. 2022 Jan;293:118523 |
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