氯代环己烷
Cyclohexyl chloride
CAS: 542-18-7
Molecular Formula: C6H11Cl
氯代环己烷 - Names and Identifiers
| Name | Cyclohexyl chloride |
| Synonyms | IL8RA Chlorocyclohexane Chlorhexamethylene Cyclohexyl chloride 3-chloro-cyclohexen 3-chlorocyclohexane 1-Chlorocyclohexane 3-chloro-1-cyclohexene Chlorocyclohexane,typically Chlorocyclohexane, typically Anti-CXCR1 (C-terminal) antibody produced in rabbit |
| CAS | 542-18-7 |
| EINECS | 208-806-6 |
| InChI | InChI=1/C6H11Cl/c7-6-4-2-1-3-5-6/h6H,1-5H2 |
| InChIKey | UNFUYWDGSFDHCW-UHFFFAOYSA-N |
氯代环己烷 - Physico-chemical Properties
| Molecular Formula | C6H11Cl |
| Molar Mass | 118.6 |
| Density | 1 g/mL at 25 °C (lit.) |
| Melting Point | -44 °C (lit.) |
| Boling Point | 142 °C (lit.) |
| Flash Point | 84°F |
| Water Solubility | 0.02 g/L (20 ºC) |
| Solubility | 0.40g/l |
| Vapor Presure | 7 hPa (20 °C) |
| Appearance | Liquid |
| Color | Clear |
| Merck | 14,2732 |
| BRN | 1900796 |
| Storage Condition | Store below +30°C. |
| Explosive Limit | 1.1-7.5%(V) |
| Refractive Index | n20/D 1.462(lit.) |
| Physical and Chemical Properties | Character this product is colorless liquid, with asphyxiating odor. melting point -44 ℃ boiling point 142 ℃ relative density 1.000 refractive index 1.4626 solubility insoluble in water, soluble in ethanol. |
| Use | Can produce pesticides, rubber scorch agent, medicine, etc |
氯代环己烷 - Risk and Safety
| Risk Codes | R10 - Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. R20 - Harmful by inhalation |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection S16 - Keep away from sources of ignition. |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 1 |
| RTECS | GU8685000 |
| TSCA | Yes |
| HS Code | 29035990 |
| Hazard Class | 3 |
| Packing Group | III |
| Toxicity | LD50 orally in Rabbit: 3000 mg/kg |
氯代环己烷 - Upstream Downstream Industry
| Raw Materials | Cyclohexanol Cyclohexanol Hydrochloric acid |
| Downstream Products | Azocyclotin N-(Cyclohexylthio)phtalimide |
氯代环己烷 - Nature
Open Data Verified Data
This product is a colorless liquid with asphyxiating odor. Boiling point 142 °c. Melting Point -44 °c. The relative density was 1.000. Refractive index 4626. Insoluble in water, soluble in ethanol.
Last Update：2025-06-10 22:55:16
氯代环己烷 - Preparation Method
Open Data Verified Data
obtained by chlorination of cyclohexanol. Mix cyclohexanol with hydrochloric acid, heat on water bath (85 ℃), reflux, when the internal temperature gradually increased to about 104 ℃, Reflux reaction is completed, cooling to room temperature, after standing and stratification, the acid water was discarded, washed with saturated brine and saturated nahco3 solution once respectively, dehydrated with anhydrous calcium chloride, fractionated, and the fraction at 141~142 ℃ was collected, is the product.
Last Update：2022-01-01 10:38:21
氯代环己烷 - Application
Open Data Verified Data
pharmaceutical intermediates for the preparation of antiepileptic, spasmodic drug benzhexol hydrochloride.
Last Update：2025-08-19 16:24:40
氯代环己烷 - Safety
Open Data Verified Data
- cyclohexane has anesthetic and skin stimulating effects, and the halogenated substance has a stronger effect. The production workshop shall be well ventilated and the equipment shall be closed. The operator should wear protective gear.
- This product is shipped in iron drum or tank car. This product is flammable. Should be stored in a dry, cool, well-ventilated warehouse. Keep away from fire and heat source. Sun protection, protection against impact. According to the provisions of flammable materials storage and transportation. Light packing and light unloading to prevent package breakage.
Last Update：2025-06-10 22:55:16
氯代环己烷 - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| overview | chlorocyclohexane is a basic raw material for organic synthesis and an important fine chemical product. It is mainly used as an intermediate of rubber anti-scorch agent CTP, pharmaceutical benzohydrin hydrochloride, pesticide tricyclic tin and other products. It can also be used for synthesis of polyurethane foaming catalyst N,N-dimethylcyclohexylamine, rust inhibitor, etc. |
| preparation | add 158g of cyclohexane into a four-port flask equipped with a stirrer, a thermometer, a reflux condenser and a chlorination tube, add 0.1g of composite catalyst, place the four-port flask in the dark, start stirring, rotate 100 r/min, heat up to 60 ℃, pass in chlorine at a speed of 0.05l/min, and maintain 10-20min; Then cool down to 40 ℃, increase the rate of chlorine gas intake so that 50g of chlorine gas is introduced within 4 hours. After the reaction material is neutralized with sodium carbonate and washed with water, it is first distilled at normal pressure to obtain 101.5g of unreacted cyclohexane for the next synthesis, and then the 81-85 ℃ fraction is collected at a vacuum degree of 0.08MPa to obtain 68.2g of chlorocyclohexane. The product was analyzed by HP6890 gas chromatography, the content was 99.65%, the one-way conversion rate of cyclohexane was 35.8%, the selectivity was 88.9%, and the yield was 85.5%. |
| Use | Can be used to produce pesticides, rubber anti-scorch agents, medicines, etc. Used in organic synthesis Can produce pesticides, rubber, it can also be used to make anti-scorch agent GP and other products. Pharmaceutical intermediates, used to make anti-epileptic and spasmodic drugs benhexol hydrochloride. It is also an intermediate of the pesticide tricyclic tin and a rubber anti-scorch agent. |
| production method | obtained from chlorination of cyclohexanol: cyclohexanol and 30% hydrochloric acid are mixed and stirred, heated to 85 ℃, refluxed for 12h, and the temperature gradually rises to about 103 ℃. At the end of reflux, cool to 20 ℃, let stand and layer, remove acid water, wash once with sodium chloride saturated solution and sodium carbonate solution respectively, dry with anhydrous calcium chloride, fractionate, collect 141-142.5 ℃ fractions to obtain chlorocyclohexane. The yield was 83%. There are two methods for the synthesis of chlorocyclohexane. (1) Cyclohexanol chlorination method mixes and stirs cyclohexanol with 30% hydrochloric acid, raises the temperature to 85 ℃, refluxes for 12h, and the internal temperature gradually rises to about 103 ℃; After reflux, cool to 20 ℃, stand for stratification, remove acid water, wash once with sodium chloride saturated solution and sodium carbonate solution respectively, dry with anhydrous calcium chloride, fractionate, collect fraction at 141~142.5 ℃, and obtain chlorocyclohexane with a yield of 83%. (2) Cyclohexane chlorination is prepared by chlorination of cyclohexane with chlorine. Cyclohexane is added to the reactor, and chlorine gas is passed at 50~90 ℃. After analysis, the reaction can be stopped when the content of chlorocyclohexane reaches more than 70%. Generally, after 2 hours of reaction, the conversion rate of cyclohexane can reach more than 70%. The reaction material is rectified to recover unreacted cyclohexane. |
| category | flammable liquid |
| toxicity classification | low toxicity |
| acute toxicity | inhalation-rat LCL0:31000 mg/m3; Inhalation-mouse LC50:31000 mg/m3/2 h |
| flammability hazard characteristics | it is more flammable when exposed to open flames, high temperatures, and oxidants; combustion produces toxic chloride fumes |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; separate from oxidant |
| fire extinguishing agent | dry powder, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent |
| occupational standard | STEL 50 mg/m3 |
| spontaneous combustion temperature | 290°C |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:04:16
Supplier List
Featured ProductsMultiple SpecificationsSpot supply
Product Name: Chlorocyclohexane Request for quotationCAS: 542-18-7
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Featured ProductsSpot supply
Product Name: Chlorocyclohexane Visit Supplier Webpage Request for quotationCAS: 542-18-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Cyclohexyl chloride Request for quotationCAS: 542-18-7
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Spot supply
Product Name: Cyclohexyl chloride Request for quotationCAS: 542-18-7
Tel: +86-17505207175
Email: 3787852685@qq.com
Mobile: +86-17505207175
QQ: 3787852685
Wechat: chemical6666
Spot supply
Product Name: Cyclohexyl chloride Request for quotationCAS: 542-18-7
Tel: +86-13776910623
Email: r@reformchem.com
Mobile: +86-13776910623
QQ: 3785839865
Wechat: chemical6666
Spot supply
Product Name: Chlorocyclohexane Request for quotationCAS: 542-18-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Chlorocyclohexane Visit Supplier Webpage Request for quotationCAS: 542-18-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Chlorocyclohexane Visit Supplier Webpage Request for quotationCAS: 542-18-7
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: Cyclohexyl chloride Request for quotation
CAS: 542-18-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 542-18-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: Cyclohexyl chloride Request for quotation
CAS: 542-18-7
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
CAS: 542-18-7
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
Featured ProductsMultiple SpecificationsSpot supply
Product Name: Chlorocyclohexane Request for quotationCAS: 542-18-7
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Featured ProductsSpot supply
Product Name: Chlorocyclohexane Visit Supplier Webpage Request for quotationCAS: 542-18-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Cyclohexyl chloride Request for quotationCAS: 542-18-7
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Spot supply
Product Name: Cyclohexyl chloride Request for quotationCAS: 542-18-7
Tel: +86-17505207175
Email: 3787852685@qq.com
Mobile: +86-17505207175
QQ: 3787852685
Wechat: chemical6666
Spot supply
Product Name: Cyclohexyl chloride Request for quotationCAS: 542-18-7
Tel: +86-13776910623
Email: r@reformchem.com
Mobile: +86-13776910623
QQ: 3785839865
Wechat: chemical6666
Spot supply
Product Name: Chlorocyclohexane Request for quotationCAS: 542-18-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Chlorocyclohexane Visit Supplier Webpage Request for quotationCAS: 542-18-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Chlorocyclohexane Visit Supplier Webpage Request for quotationCAS: 542-18-7
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: Cyclohexyl chloride Request for quotation
CAS: 542-18-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 542-18-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: Cyclohexyl chloride Request for quotation
CAS: 542-18-7
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
CAS: 542-18-7
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
View History
Raw Materials for 氯代环己烷
Downstream Products for 氯代环己烷