柠檬酸三锌
trizinc dicitrate
CAS: 546-46-3
Molecular Formula: C6H8O7Zn
柠檬酸三锌 - Names and Identifiers
| Name | trizinc dicitrate |
| Synonyms | Zinc citrate ZINC CITRATE trizincdicitrate zinc citrate Zn3( trizinc dicitrate food grade hot sale zinc citrate zinc(II) 2-hydroxypropane-1,2,3-tricarboxylate |
| CAS | 546-46-3 |
| EINECS | 208-901-2 |
| InChI | InChI=1/2C6H8O7.3Zn/c2*7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h2*13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;;3*+2/p-6 |
柠檬酸三锌 - Physico-chemical Properties
| Molecular Formula | C6H8O7Zn |
| Molar Mass | 257.5 |
| Boling Point | 309.6°C at 760 mmHg |
| Flash Point | 155.2°C |
| Water Solubility | slightly soluble H2O; soluble dilute mineral acids and alkali hydroxides [MER06] |
| Vapor Presure | 5.73E-05mmHg at 25°C |
| Appearance | colorless powder |
| Physical and Chemical Properties | Lemon yellow or light yellow powder. Slightly soluble in water, its solubility is 2.6g/L. |
| Use | Mainly used in food, solid beverages, dairy products, infant food, salt, toothpaste, health products, etc |
柠檬酸三锌 - Upstream Downstream Industry
| Raw Materials | Citric acid Zinc oxide |
柠檬酸三锌 - Standard
Authoritative Data Verified Data
This product shall be calculated as dried product, and the content of (C6H507)2Zn3 shall not be less than 98.5%.
Last Update：2024-01-02 23:10:35
柠檬酸三锌 - Trait
Authoritative Data Verified Data
- This product is white granular crystal or crystalline powder; Odorless; Weathering.
- This product is slightly soluble in water and dissolved in hydrochloric acid solution.
Last Update：2022-01-01 13:39:34
柠檬酸三锌 - Differential diagnosis
Authoritative Data Verified Data
This product shows the identification reaction of zinc salt and citrate (General rule 0301).
Last Update：2022-01-01 13:39:34
柠檬酸三锌 - Exam
Authoritative Data Verified Data
acidity
Take 10 mg of this product, add 10ml of water, stir for 5 minutes, filter, add 1 drop of methyl orange indicator solution to the filtrate, and do not show orange red.
alkalinity
take l.Og of this product, heat water 10ml, stir for 5 minutes, let cool, filter, add 2 drops of phenolphthalein indicator solution to the filtrate, and do not show pink.
loss on drying
take this product, dry at 180°C for 6 hours, loss of weight shall not exceed 6.5% (General rule 0831).
Iron Salt
take 0.20g of this product, add 4ml of dilute hydrochloric acid and an appropriate amount of water, shake to dissolve, and check according to law (General rule 0807), it should not be deeper (0.005%) compared with of standard iron solution prepared by the same method.
lead salt
take 0.50g of this product, put it in a beaker, add 3ml of nitric acid and 1 ml of 30% hydrogen peroxide solution, heat and boil it for 2 minutes, let it cool, dilute it to 10ml with water, and shake it well, as a test solution. In addition, 0.5 of standard lead solution (containing 10ug of lead per 1 ml) was accurately measured, and the same method was used as a control solution. Take h as described in two solutions under Atomic Absorption Spectrophotometry (General rule 0406) at 217. At the wavelength of Onm, the absorbance of the test solution shall not be greater than that of the control solution (0.001%).
arsenic salt
take L. 0g of this product, add 5ml of hydrochloric acid and 21ml of water, shake to dissolve, check according to law (General Principles 0822 first law), should comply with the provisions (0.0002%).
Last Update：2022-01-01 13:39:35
柠檬酸三锌 - Content determination
Authoritative Data Verified Data
take this product about 0.2g, precision weighing, add water 20ml and oxygen-ammonium chloride buffer (pH10.0)10ml, shake to dissolve, add a small amount of Chrome Black T indicator, titrated with ethylene diamine tetraacetic acid disodium titration solution (0.05mol/L) until the solution changed from purple to pure 1 blue. Each 1 ml of ethylenediamine tetraacetic acid disodium titration solution (0.05mol/L) is equivalent to 9.572mg (C6H507)2 zn3.
Last Update：2022-01-01 13:39:36
柠檬酸三锌 - Category
Authoritative Data Verified Data
zinc supplement.
Last Update：2022-01-01 13:39:36
柠檬酸三锌 - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 13:39:36
柠檬酸三锌 - Zinc citrate tablets
Authoritative Data Verified Data
This product contains zinc citrate [(C6H507) 2Zn3 • 2H20] should be 95.0% ~ 105.0% of the label.
trait
This product is white tablet.
identification
This product shows the identification reaction of zinc salt and citrate (General rule 0301).
examination
- dissolution: according to the determination method of dissolution and release (General rule 0931, Method 1), dilute hydrochloric acid (24ml) and water (100 ml) were added as dissolution medium, and the rotation speed was rpm, operate in accordance with the law, after 30 minutes, take the solution filter, take the filtrate 3ml, put it in a 25ml measuring flask, dilute to the scale with the dissolution medium, shake, as a test solution; in addition, the zinc citrate reference substance was accurately weighed, and the solution containing 2%, 4ug and 6ug per 1 ml was prepared by dissolving the medium and quantitatively diluting the solution. Take the above two solutions according to Atomic Absorption Spectrophotometry (General rule 0406 method 1), measured at the wavelength of 213.9nm, calculate the dissolution of each tablet, limit is 80% of the label amount, the requirements shall be met.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 10 tablets of this product, precision weighing, fine grinding, precision weighing appropriate amount (about 0.4g equivalent to zinc citrate), put it in a 100ml measuring flask, add 2ml of dilute hydrochloric acid, add appropriate amount of water and shake to dissolve zinc citrate and dilute to the scale, shake well, filter, take 50ml of continuous filtrate with precision, and add 1 drop of 0.025% methyl red ethanol solution, add ammonia test solution Dropwise to the solution of micro-yellow, ammonia-ammonium chloride buffer (pH 10.0)10ml with a small amount of Chrome Black T indicator, with ethylenediamine tetraacetic acid disodium titration solution (0.05mol/L) titration was performed until the solution changed from purple to pure blue. Each 1 ml of ethylene diamine tetraacetic acid disodium titration solution (0.05mol/L) corresponds to 10.17mg of (CgH5O7) 22n3.2h2o.
category
with zinc citrate.
specification
12.5mg (as Zn)
storage
sealed storage.
Last Update：2022-01-01 13:39:37
柠檬酸三锌 - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| introduction | zinc citrate, also known as zinc citrate, is a drug used to supplement zinc, such as loss of appetite, anemia, growth retardation, nutritional dwarf, male hypogonadism and enteropathic acrodermatitis caused by zinc deficiency. It is also used in rheumatoid arthritis, intermittent claudication, hepatolenticular degeneration, ulcer, chronic ulcer, conjunctivitis, aphtha and other diseases. |
| use | 1. children's growth retardation, malnutrition, anorexia, pica, etc. caused by zinc deficiency; 2. it can be used to treat adolescent anorexia and childhood zinc deficiency. As a food zinc fortifier, the absorption effect is better than inorganic zinc. mainly used in paints, inks, rubber, plastics and fine arts pigments, etc. mainly used as food additives mainly used in food, solid beverages, dairy products, infant food, salt, toothpaste, health products, etc. zinc citrate is used to treat children's growth retardation, protein-energy malnutrition (malnutrition), anorexia, pica, etc. |
| clinical application | is used to treat children's growth retardation, malnutrition, anorexia and pica caused by zinc deficiency. |
| drug interaction | 1. this product should not be taken with milk. 2. This product should not be used at the same time as aluminum salt, calcium salt, carbonate, tannic acid, etc. 3. This product can reduce the effect of penicillamine and tetracycline drugs. 4. If drug interaction may occur when used simultaneously with other drugs, please consult your doctor or pharmacist for details. |
| synthesis method | take 10.94kg of citric acid, add 44L of distilled water, stir and dissolve, filter, and heat the filtrate to 40~42 ℃; In addition, 6.35kg of zinc oxide (100 mesh) is taken, 26L of distilled water is added, stirred into a dilute paste suspension, and the 100 r/min is gradually added into citric acid solution under severe stirring, continue to stir and keep the temperature at 40~42 ℃ until the reaction solution is clear, continue to stir for 5 minutes, add 0.1% activated carbon and stir for 10 minutes, filter while hot, place the filtrate at room temperature for 24~48 hours, pour out the supernatant, filter, collect the precipitated crystals, wash the crystals twice with distilled water until the washing solution is pH = 6, drain, and dry at 60 ℃ to obtain white zinc citrate,. The yield of zinc citrate was 14.2kg, the yield was 82.1%, and the purity was 98.2%. |
| preparation method | zinc citrate tablets are made of the following raw materials: zinc citrate 10%, lactose 40%, starch 10%, pregelatinized starch 25%, low substituted hydroxypropyl cellulose 5%, sodium carboxymethyl starch 5%, magnesium stearate 5%. The preparation method includes the following steps:(1) Weighing raw materials: weigh zinc citrate, lactose, starch, pregelatinized starch, low-substituted hydroxypropyl cellulose, sodium carboxymethyl starch, and magnesium stearate according to the above weight percentage content;(2) Superfine grinding of raw materials: superfine grinding of the raw materials weighed in step (1), and the raw materials after superfine grinding are 100 mesh, after crushing, the fine powder is obtained through a 100 mesh sieve, and part of the starch fine powder is taken to make a starch slurry with a mass concentration of 5% and a temperature of 25 ℃;(3) Granulation: The zinc citrate fine powder, lactose fine powder, pre-gelatinized starch fine powder, remaining starch fine powder, and low-substituted hydroxypropyl cellulose fine powder prepared in step (2) are mixed evenly, then starch slurry is added, and wet granules are made after stirring for 5 minutes;(4) Drying: The wet particles prepared in step (3) are dried at 50 ℃ for 3 hours;(5) tabletting: the dried particles in step (4) are whole granulated, and then the carboxymethyl starch sodium micropowder and magnesium stearate micropowder prepared in step (2) are added and mixed, and then tableted to obtain plain tablets. |
| production method | 10.5g(0.05 mo1) citric acid is dissolved in 100mL of distilled water, 6.1g(0.075 mo1) zinc oxide is added into it in batches, and heated and stirred in a water bath at 60~80 ℃ for 2 hours; Filtering while hot, the filtrate is concentrated to 1/3 of the original volume under reduced pressure, and ethanol of 10mL 95% is added, at room temperature. Let it stand for 6 hours, filter, wash and vacuum dry to obtain 14.8g of white powdered zinc citrate product with 96.2% yield and 99.6% purity. |
Last Update：2024-04-09 20:00:08
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Product Name: Zinc citrate Request for quotationCAS: 546-46-3
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