当归提取物(藁本内酯LIGUSTILIDE
Ligustilide
CAS: 4431-01-0
Molecular Formula: C12H14O2
当归提取物(藁本内酯LIGUSTILIDE - Names and Identifiers
当归提取物(藁本内酯LIGUSTILIDE - Physico-chemical Properties
| Molecular Formula | C12H14O2 |
| Molar Mass | 190.24 |
| Density | 1.10±0.1 g/cm3(Predicted) |
| Melting Point | 297-298°C |
| Boling Point | 377.9±11.0 °C(Predicted) |
| Flash Point | 158.6°C |
| Solubility | Soluble in methanol, chloroform, ether, insoluble in water |
| Vapor Presure | 6.55E-06mmHg at 25°C |
| Appearance | Oily liquid (light yellow liquid) |
| Storage Condition | -20 ℃, stored with nitrogen |
| Refractive Index | 1.544 |
| MDL | MFCD01861511 |
| Physical and Chemical Properties | Light yellow liquid, soluble in methanol, chloroform, ether, insoluble in water, from Chuanxiong, Angelica. |
当归提取物(藁本内酯LIGUSTILIDE - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| UN IDs | 2810 |
| HS Code | 29322090 |
当归提取物(藁本内酯LIGUSTILIDE - Reference
| Reference Show more | 1. Zhang Xing Ying Xin Yan Rong Cai Liang Hui Lin Yameng Yang Ye Lu Hui Zhen Cui Xiuming Liu Yi Wang Cheng Xiao Qu Yuan. Study on drying characteristics and kinetics of Angelica sinensis [J]. Anhui Agricultural Sciences 2017 45(05):102-106 178. 2. Guo Jiangyu, Sun Lei, Yan Yan et al. Effect of combined decoction and single decoction on dissolution of four chemical components in Siwu decoction [J]. Journal of Tianjin University of Traditional Chinese Medicine 2017(5). 3. Ru, Qingguo, Peng, Yu, MA, Shu, Wei, et al. Optimization of preparation technology of Angelica sinensis supercritical extract colon-specific pellets by response surface methodology [J]. Chinese Journal of Traditional Chinese Medicine 2016(13):2442-2448. 4. Yan Menglin, Ding Guoyu, Cong Longfei, et al. Rapid near-infrared evaluation of Angelica sinensis vasodilation efficacy based on quality markers [J]. Chinese herbal medicine, 2019, v.50;No.654(19):27-35. 5. Zhang Qing, Ru Qingguo, Peng Yu, etc. Release behavior of Angelica sinensis volatile oil colon-targeted pellets in rat digestive tract [J]. Journal of Beijing University of Traditional Chinese Medicine, 2016, 39(010):855-859. 6. Zhou Jing, Li Ling, Wang Bing, et al. Optimization of alcohol extraction process and water extraction process of Pingtang compound by orthogonal test [J]. Chinese Journal of Experimental prescriptions, 2016(22):26-30. 7. Zhou Jing, Li Ling, Cui Dongxue, etc. Optimization of β-Cyclodextrin Inclusion process of volatile oil in Pueraria compound by orthogonal test [J]. Shi-zhen, National Medicine, 2017(01):113-116. 8. Yang Qiqi, Zhu Xujiang, Wang lanxia, etc. Study on improving the quality standard of Shenghua pills [J]. Journal of Chinese veterinary medicine, 2020, v.39;No.220(01):56-60. 9. Wang Zhenheng, Wang Yinquan, Fan Qin, et al. Effects of ultraviolet-B radiation on phthalide content in angelica sinensis [J]. Journal of Gansu University of Chinese Medicine, 2019(6). 10. Zhou Jing, Li Ling, Wang Bing, et al. Optimization of extraction process of volatile oil and water-soluble components from Pueraria compound [J]. Chinese patent medicine, 2017(3). 11. Huang Meisong, Liu Peng, Wang Shicai, etc. Ligustilide inhibits myocardial hypertrophy induced by angiotensin Ⅱ and its mechanism [J]. Chinese Journal of Experimental prescriptions, 2016, 022(013):150-155. 12. Yan Shunan, Wang Yinquan, Ma Lili, et al. Optimization of balanced dehydration drying process of Angelica sinensis [J]. Chinese patent medicine, 2020, v.42(03):135-142. 13. Yao Hongjuan, Zhao Changyue, Jiang Luqing, etc. Study on Pharmacognosy and fingerprint of radix angelicae sinensis from Korean Medicine [J]. Chinese herbal medicine, 2018, (6):1384-1390. 14. Zhang Jingzhi, Zhao Danqing, Wang Zhengrong, etc. Simultaneous determination of the contents of seven active ingredients in Yao Yao yuili Yao mi spray by one-Test multi-evaluation method [J]. China Pharmacy, 2020(9). 15. Cheng Jiang-Xue, Tang Zhi-shu, Guo Dong-yan, et al. Effect of different compatibility ratio on dissolution of 10 components in Radix Paeoniae rubra-radix angelicae Sinensis [J]. Journal of Pharmaceutical Analysis, 2019, v.39(09):73-80. 16. Liu Min. Study on the effective substance of danggui decoction for the Prevention of inflammation related colorectal cancer and the construction of multiple drug delivery system [D]. Beijing University of Chinese Medicine, 2020. 17. Peng Tong, Wang Yinquan, Zhang Yali, Yan Shunan, Qin Jun, Ma Qin state. Comparison of 8 effective components between Angelica sinensis of Linqu and Minxian County [J]. Journal of Gansu University of Chinese Medicine, 2020,37(06):29-33. 18. Zhu Lin, Liu Dongsheng, Zhu Xujiang, Su Rui, Yao Shixia, He Junquan, Yang Pingrong. Improvement of quality standard of danggui Abdominal Pain Ning dropping pills [J]. Chinese national folk medicine, 2020,29(20):32-38. 19. Zhang, natiing, et al. "Pharmacokinetics-based identification of potential therapeutic drugs from XueBiJing, a Chinese herbal injection used in sepsis management." Drug Metabolism and Disposition 46.6 (2018): 823-834.DOI: https://doi.org/10.1124/dmd.11 20. [IF=4.379] Chen Wei-Ren et al."Phthalide Derivatives from Angelica Sinensis Decrease Hemoglobin Oxygen Affinity: A New Allosteric-Modulating Mechanism and Potential Use as 2,3-BPG Functional Substitutes."Sci Rep-Uk. 2017 Jul;7(1):1-15 21. [IF=6.529] Yan He et al."Pharmacokinetics and biotransformation investigation in beagle dog of active compounds from naoxintong capsule."Biomed Pharmacother. 2021 Jan;133:110940 22. [IF=5.923] Jia Liu et al."Supercritical Fluid Extract of Angelica sinensis and Zingiber officinale Roscoe Ameliorates TNBS-Induced Colitis in Rats."Int J Mol Sci. 2019 Jan;20(15):3816 23. [IF=5.81] Yan Tao et al."Ligustilide Prevents Radiation Enteritis by Targeting Gch1/BH4/eNOS to Improve Intestinal Ischemia."Front Pharmacol. 2021 Apr;0:893 24. [IF=4.36] Shi-Jie Bi et al."Network pharmacology-based study on immunomodulatory mechanism of danggui-yimucao herb pair for the treatment of RU486-induced abortion."J Ethnopharmacol. 2022 Jan;282:114609 25. [IF=4.36] Xiaoli Zhao et al."Transcriptomic study of the mechanism by which the Kai Yu Zhong Yu recipe improves oocyte quality in a stressed mouse model."J Ethnopharmacol. 2021 Oct;278:114298 26. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 |
当归提取物(藁本内酯LIGUSTILIDE - Active ingredient
Open Data Unverified Data
Containing ligustilide (ligusiilide), N-butenyl lactone (n-butylidene phthalide), ferulic acid, nicotinic acid, sucrose and a variety of amino acids, and sesquiterpenes, etc.
Last Update：2024-04-09 19:43:38
当归提取物(藁本内酯LIGUSTILIDE - Plant Extracts
Open Data Unverified Data
Angelica extract is a kind of used for blood circulation, regulating menstruation and relieving pain, moistening intestines and defecation, blood deficiency and chlorosis, dizziness and palpitation, irregular menstruation, amenorrhea and dysmenorrhea, deficiency cold and abdominal pain, intestinal dryness and constipation, rheumatism and arthralgia, plant extracts of tumblers and sores.
Last Update：2024-04-09 19:43:38
当归提取物(藁本内酯LIGUSTILIDE - Function
Open Data Unverified Data
Compendium of Materia Medica says: Angelica: bitter, warm, non-toxic. Warming the pain, replenishing all Qi, breaking evil blood, and nourishing new blood.
Its skin care and beauty effect comes from the expansion of skin capillaries and the acceleration of blood circulation. Angelica is rich in trace elements, can Nutrition skin, prevent rough. Can be used for acne, brown spots, freckles and hair loss. Angelica alias for the Qin, cloud, is a perennial herbaceous plants. Its stems are purple and are generally born in Alpine and rainy mountainous areas, such as Yunnan and Sichuan. Women eat in moderation, there are blood, regulating pain, Runchang laxative effect, Chinese medicine believes that Angelica has blood nourishing, Runchang laxative effect, it is suitable for blood deficiency caused by the face of chlorosis, dizziness and palpitation, irregular menstruation, amenorrhea dysmenorrhea or postpartum blood loss, menopausal depression, irritability and other symptoms. Therefore, it is hailed as "the holy medicine of women" by traditional Chinese medicine ".
This product has anticholinergic, antioxidant and free radical scavenging effects, can inhibit uterine contraction. The role of the uterus has a "two-way", its water-soluble non-volatile substances can excite the uterine muscle, so that the contraction is strengthened, its volatile components can inhibit the uterus, reduce its rhythmic contraction, so that the uterus relaxation.
This product also has the effect of treating vitamin E deficiency. It also reduces the excitability of the myocardium, has a therapeutic effect on atrial fibrillation, and inhibits the amplitude and frequency of cardiac contraction. Can lower blood pressure, so that a slight decline in blood lipids, the aortic disease has a preventive effect. It has a certain effect on the treatment of atherosclerosis.
Last Update：2024-04-09 19:43:38
当归提取物(藁本内酯LIGUSTILIDE - Safe dose
Open Data Unverified Data
For the treatment of dysmenorrhea, menstrual irregularities and endometriosis, the general recommend dose is 600-800mg of Angelica sinensis extract (with 1% artemisinin as the standard) per day. This dose is taken in 3 divided doses per day. Angelica may cause some fair-skinned people to be overly sensitive to sunlight. People who regularly take Angelica should limit exposure to sunlight or other sources of ultraviolet radiation for too long. Angelica is not recommend taken by pregnant or lactating women.
Last Update：2024-04-09 19:43:38
当归提取物(藁本内酯LIGUSTILIDE - Reference Information
| brief introduction | chuanxiong Hort. chuanxiong Hort. it has good effects of removing wind and dampness, promoting blood circulation and relieving pain. it can relieve pain in many parts of the body. chuanxiong source essential oil is the essence extracted from chuanxiong Hort through supercritical technology, and is further concentrated as a beneficial component of chuanxiong Hort, therefore, it will have a better relief effect on the pain of the body, especially the joint pain caused by rheumatism. You can ask to take a drop of essential oil and apply it to the pain, and then massage with your hands to promote the absorption of essential oil. For women's amenorrhea, irregular menstruation will also have a good relief effect. |
| main components | mainly contain phthalide components: 3-butylphenyl peptide, snake bed peptide lactone, etc. Organic acid components: ferulic acid, etc. It also contains terpenoids, allylbenzene, coumarin, volatile oil, etc. |
| Source | Ligusticum is the dried stems and roots of Umbelliferae plants Ligusticum or Ligusticum. Gao Ben is mainly produced in Sichuan, Hubei and Shaanxi. Perennial herb, about 1 meter high. The rhizome is an irregular mass with many fibrous roots. The stem is erect, hollow, with longitudinal edges on the surface. The basal leaves are triangular, 2 odd-numbered pinnately divided, and the final lobes are 3~4 pairs, ovate, with papillary protrusions along the vein on the top, and irregular pinnately deep lobes on the edges; the upper leaves of the stem have extended leaf sheaths. Dig when the stems and leaves wither in autumn or emerge in the next spring to remove sediment, dry or dry. Cut thick slices for raw use. |
| efficacy and action | ligusticum neutral oil has sedative, analgesic, antipyretic and anti-inflammatory effects, and can inhibit intestinal and uterine smooth muscle, but also can significantly slow down the rate of oxygen consumption, prolong the survival time of mice, increase tissue hypoxia tolerance, and resist myocardial ischemia in rats caused by pituitrin. Alcohol extract has antihypertensive effect and antibacterial effect on common pathogenic dermatophytes. Ligustilide, phthalide and their derivatives can relax the tracheal smooth muscle of experimental animals and have obvious antiasthmatic effect. |
| application field | 1. cold and cold, top pain: this product is pungent, warm, fragrant and dry, and has a good taste. it is good at the top of the top. it is good at spreading the wind, cold and dampness of the sun meridian, and has a good analgesic effect. it is commonly used to treat the wind and cold of the sun, and the symptoms include headache, nasal congestion, top pain and even the top, every time it is used with Qianghuo, Atractylodes Rhizoma, Ligusticum chuanxiong and other wind-dampness-removing and painkillers, such as Shenshu San ("Heji Bureau Prescription"); if the external wind is cold and wet, and the head and body pain is obvious, it is often compatible with Qianghuo, Duhuo, Antiwind and other medicines to dispel wind and cold, dehumidification and relieve pain, such as Qianghuo Shengshi Decoction ("Internal Trauma Discrimination"). 2. Wind-cold-dampness arthralgia: This product is pungent, warm, fragrant and dry, and can enter between muscles, meridians, muscles and bones to remove wind-cold-dampness pathogens and relieve pain. |
| uses | ligustilide has the functions of antispasmodic, relieving asthma, sedation, improving microcirculation, relaxing smooth muscle, inhibiting bacteria and improving immune regulation of the body. used for content determination/identification/pharmacological experiment, etc. Pharmacological effect: mainly used to treat gynecological diseases, relieve muscle tension, etc. |
Last Update：2024-04-09 02:00:08
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