吡啉酸
2,3-Pyridinedicarboxylic acid
CAS: 89-00-9;339155-13-4
Molecular Formula: C7H5NO4
吡啉酸 - Names and Identifiers
| Name | 2,3-Pyridinedicarboxylic acid |
| Synonyms | AKOS AUF2085 QUINOLIC ACID Quinolinic Acid AKOS BBS-00003814 RARECHEM AL BO 0810 2,3-pyridine dicarbo 2,3-Pyridinedicarboxylic Pyridine-2,3-dicarboxylate Pyridin-2,3-dicarbonsaeure 2,3-PYRIDINEDICARBOXYLIC ACID 2,3-Pyridinedicarboxylic acid 2,3-pyridine dicarboxylic acid Pyridine-2,3-dicarboxylic acid 2,3-PYRIDINEDICARBOXYLIC ACID (QUINOLINIC ACID) |
| CAS | 89-00-9 339155-13-4 |
| EINECS | 201-874-8 |
| InChI | InChI=1/C7H5NO4/c9-6(10)4-2-1-3-8-5(4)7(11)12/h1-3H,(H,9,10)(H,11,12)/p-2 |
| InChIKey | GJAWHXHKYYXBSV-UHFFFAOYSA-N |
吡啉酸 - Physico-chemical Properties
| Molecular Formula | C7H5NO4 |
| Molar Mass | 167.12 |
| Density | 1.5216 (rough estimate) |
| Melting Point | 188-190 °C (dec.) (lit.) |
| Boling Point | 295.67°C (rough estimate) |
| Flash Point | 210.9°C |
| Water Solubility | 0.55 g/100 mL |
| Solubility | Soluble in water and alkali solution, slightly soluble in ethanol, insoluble in ether and benzene. |
| Vapor Presure | 5.55E-08mmHg at 25°C |
| Appearance | White solid |
| Color | White to light yellow-beige |
| Merck | 14,8073 |
| BRN | 137110 |
| pKa | 2.43(at 25℃) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.6280 (estimate) |
| MDL | MFCD00006295 |
吡啉酸 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R33 - Danger of cumulative effects |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S24/25 - Avoid contact with skin and eyes. S37 - Wear suitable gloves. |
| WGK Germany | 3 |
| RTECS | US7967250 |
| TSCA | T |
| HS Code | 29333999 |
| Hazard Class | IRRITANT |
| Toxicity | Focal injection of quinolinic acid into specific areas of the brain produces neuronal damage although sparing axons of passage. Similarities between the biochemical and morphological profiles of these lesions and human neuropathy seen in neurodegenerative diseases have led to the proposal that endogenous excitotoxins may play a role in such neurodegenerative disease states. Quinolinic acid is an intermediate in the kynurenine pathway of tryptophan metabolism and has been detected in the brains of several mammals including man. The neuroexcitatory action is thought to be mediated via interaction with the N-methyl-D-aspartate (NMDA) receptor of the glutamate family. No mechanism for quinolinic acid removal, nor for synaptic inactivation, has been found, and consequently accumulation of concentrations capa_x0002_ble of inducing neuronal degeneration and death may occur. |
吡啉酸 - Introduction
Decompose when heated, 190-195 ℃ (decomposition), soluble in water and alkali solution, slightly soluble in ethanol, insoluble in ether and benzene.
Last Update：2022-10-16 17:29:36
吡啉酸 - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | 2, 3-pyridinedicarboxylic acid is colorless columnar crystal, slightly soluble in water, insoluble in benzene and ether. It can be used as pharmaceutical intermediates, pesticide intermediates, Organic Synthesis Reagents. |
| Use | inhibition of glucose synthesis used as an organic synthesis reagent pyridine -2,3-dicarboxylic acid is an intermediate of the herbicide imidazonicotinic acid. The intermediates of nicotinic acid, nicotinamide, nikethamide and the like are also copper ion measurement reagents. |
| production method | was prepared by oxidation of quinoline with nitric acid. The preparation method is based on acrolein and oxaloacetic acid Diethyl ester, ammonium chloride as raw materials, in the presence of catalyst in ethanol, reaction heating reflux, cooling to pyridine -2,3 dicarboxylic acid ester and then hydrolyzed products. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 15:16:53
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View History
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