双异丙酚
Disoprofol
CAS: 2078-54-8
Molecular Formula: C12H18O
双异丙酚 - Names and Identifiers
| Name | Disoprofol |
| Synonyms | PD18215 diprivan propofol Disoprofol Diprivan10 2,6-diisopropylphenol 2,6-DIISOPROPYLPHENOL Phenol,2,6-diisopropyl- Phenol, 2,6-diisopropyl- 2,6-di(propan-2-yl)phenol 2,6-BIS(1-METHYLETHYL)PHENOL Phenol,2,6-bis(1-methylethyl)- |
| CAS | 2078-54-8 |
| EINECS | 218-206-6 |
| InChI | InChI=1/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3 |
| InChIKey | OLBCVFGFOZPWHH-UHFFFAOYSA-N |
双异丙酚 - Physico-chemical Properties
| Molecular Formula | C12H18O |
| Molar Mass | 178.27 |
| Density | 0.962 g/mL at 25 °C (lit.) |
| Melting Point | 18 °C (lit.) |
| Boling Point | 256 °C/764 mmHg (lit.) |
| Flash Point | >230°F |
| Water Solubility | Very slightly soluble in water. |
| Solubility | Sensitive to air |
| Vapor Presure | 5.6 mm Hg ( 100 °C) |
| Appearance | Transparent liquid |
| Color | Pale Yellow to Yellow |
| Merck | 14,7834 |
| BRN | 1866484 |
| pKa | pKa 11.10(H2O,t =20)(Approximate) |
| Storage Condition | 2-8°C |
| Sensitive | Sensitive to air |
| Refractive Index | n20/D 1.514(lit.) |
| MDL | MFCD00008885 |
| Physical and Chemical Properties | Melting Point 18°C(lit.) boiling point 256 ° C 764mm Hg(lit.) density 0.962g/mL at 25°C(lit.) vapor pressure 5.6mm Hg (100°C) refractive index n20/D 1.514(lit.) flash point> 230 °F storage conditions 0-6°C Merck 14,7834 BRN 1866484 |
| Use | Used as an intermediate in organic synthesis for the synthesis of novel polycyclic musk DDHI |
双异丙酚 - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S37/39 - Wear suitable gloves and eye/face protection S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S7 - Keep container tightly closed. |
| UN IDs | 2810 |
| WGK Germany | 3 |
| RTECS | SL0810000 |
| TSCA | Yes |
| HS Code | 29089990 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
双异丙酚 - Reference
| Reference Show more | 1. Liu Rui, Li Li, Li Wei, Diao Juanjuan. Preparation and Characterization of Propofol Molecularly Imprinted Polymer Microspheres [J]. Journal of Xinjiang Medical University, 2020,43(11):1495-1499. 2. [IF = 2.967] Jinhui Liu et al."Effects of propofol and sevoflurane on blood glucose, hemodynamics, and inflammatory factors of patients with type 2 diabetes mellitus and gastric cancer." Oncol Lett. 2020 Feb;19(2):1187-1194 3. [IF = 2.447] Xiaohong Yu et al."Clinical efficacy of intravenous anesthesia on breast segmental surgery and its effects on oxidative stress response and hemodynamics of patients." Exp Ther Med. 2021 Jan;21(1):1-1 4. [IF = 0.252] Yu Wang et al."Effect of epidural block anesthesia combined with general anesthesia on postoperative cognitive ability of elderly patients undergoing thoracoscopic surgery." Int J Clin Exp Patho. 2020; 13(10): 2447-2454 |
双异丙酚 - Nature
Open Data Verified Data
colorless to light yellow liquid with special odor. Soluble in most organic solvents, insoluble in water.
Last Update：2025-06-10 22:55:16
双异丙酚 - Preparation Method
Open Data Verified Data
propofol can be obtained by alkylation of phenol with isobutylene catalyzed by aluminum triphenoxide.
Last Update：2025-06-10 22:55:16
双异丙酚 - Standard
Authoritative Data Verified Data
This product is 2, 6-diisopropyl phenol, containing C12H180 should be 98.0% ~ 102.0%.
Last Update：2024-01-02 23:10:35
双异丙酚 - Trait
Authoritative Data Verified Data
- This product is a white or off-white crystalline solid (below 15°C), usually filled with colorless to yellowish clear liquid. She has peculiar odor. It gradually turned yellow when exposed to light, and quickly turned yellow when exposed to high temperature.
- This product is highly soluble in ethanol, ether or acetone; It is very slightly soluble in water.
relative density
The relative density of this product (General 0601) is 0.952~0.956.
freezing point
The freezing point of this product (General 0613) is 18.0~19.0°C.
refractive index
The refractive index of this product (General 0622) is 1.5124~1.5144.
Last Update：2022-01-01 11:34:57
双异丙酚 - Application
Open Data Verified Data
developed by Stark, launched in the UK in 1986. For short-acting intravenous general anesthetics, anesthesia and thiopental sodium similar, but the effect is about 1.8 times stronger. Rapid Action and short duration. Induction effect is good, the role of smooth, no excited phenomenon, but also through intravenous infusion or multiple use to control the depth of anesthesia, no significant accumulation, the patient recovered after a clear mind, can quickly recover. For induction of anesthesia and maintenance of anesthesia.
Last Update：2025-08-19 16:24:40
双异丙酚 - Differential diagnosis
Authoritative Data Verified Data
- take 0.1ml of this product, dissolve it with 10ml of ethanol-water (32:25), Take 5ml of the solution, and add bromine test solution to generate white precipitate that dissolves immediately, however, when the test solution is excessive, a long-lasting precipitate is generated.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 707).
Last Update：2022-01-01 11:34:57
双异丙酚 - Exam
Authoritative Data Verified Data
acidity
take L. 0ml of this product, add 25.0 of water, fully shake, stand for 5-10 minutes, separate the water layer, filter, take 10ml of filtrate, add 2 drops of Methyl red indicator solution, no red color.
clarity and color of the fermentation solution
take 1.0ml of this product, dilute it to 0901 with ethanol, shake it, and the solution should be clear and colorless; If it is colored, compare it with the yellow No. 1 Standard Colorimetric solution (General rule first method), not deeper.
Related substances
The test solution under the content measurement item was taken as a test solution. 0.5ml of the test solution was accurately measured, placed in a 500ml measuring flask, diluted to the scale with methanol, and shaken to obtain a control solution. Precision weighing 3,3 '5,5'-(tetraisopropyl) biphenyl -4,4 '-diphenol (impurity I), A solution containing 1.5ug per 1 ml was prepared by dissolving and diluting with methanol as a control solution. According to the chromatographic conditions under the content determination item, 10 u1 of the test solution, the control solution and the reference solution are accurately measured, and the human liquid chromatograph is injected respectively, and the chromatogram is recorded. If there are chromatographic peaks in the chromatogram of the test solution that are consistent with the retention time of impurity I, the peak area shall be calculated according to the external standard method, and the content of impurity I shall not exceed 0.05%, the Peak area of other individual impurities shall not be greater than 0.5 times (0.05%) of the main peak area of the control solution, and the sum of the peak areas of other impurities shall not be greater than 2 times (0.2%) of the main peak area of the control solution.
2, 6-diisopropyl-1, 4-benzoquinone (impurity II)
take the test solution under the content determination item as the test solution; Take the appropriate amount of impurity n reference substance by precision weighing, methanol was added to dissolve and diluted to prepare a solution containing about 1.5ug per 1 ml as a control solution. The detection wavelength was 254nm according to the chromatographic conditions under the content measurement. The sample solution and the reference solution were respectively injected with human liquid chromatograph, and the chromatogram was recorded. If there is a chromatographic peak in the chromatogram of the test solution that is consistent with the retention time of impurity II, the peak area shall be calculated according to the external standard method, and the impurity II shall not exceed 0.05%.
residual solvent
take about 1.0g of this product, precision weighing, put it in a 10ml measuring flask, add N,N-dimethylformamide to dissolve and dilute to the scale, shake, take 1ml, in the top empty bottle, add 2ml of N,N-dimethylformamide to the bottle and seal it as the test solution. Weigh the appropriate amount of methanol, acetone, N-hexane and toluene respectively, add N,N-dimethylformamide quantitative dilution to make each lml respectively containing methanol 0.3mg, acetone 0.5mg, N-hexane 0.029mg and toluene 0.089mg of mixed solution, precision take lml, in the top empty bottle, 2ml of N,N-dimethylformamide was added precisely, sealed, and used as a reference solution. According to the determination method of residual solvent (General 0861 second method), the capillary column with polyethylene glycol (PEG-20M)(or similar polarity) as the stationary liquid is used as the column; The initial temperature is 40°C, and the maintenance time is 1 min, the temperature is raised to 150°C at a rate of 15°C per minute and then to 220°C at a rate of 30°C per minute for 2 minutes; The temperature of the sample inlet is 180°C; And the temperature of the detector is 220°C; the Headspace bottle equilibration temperature was 80°C and the equilibration time was 30 minutes. Take the reference solution into the headspace, and the separation degree between the peaks of each component shall meet the requirements. The test solution and the reference solution were sampled by Headspace injection, and the chromatograms were recorded. According to the external standard method, the residual amount of methanol, acetone, n-hexane and toluene shall be in accordance with the regulations.
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the ignition residue item shall not contain more than 10 parts per million of heavy metals when examined by law (General rule 0821).
Last Update：2022-01-01 11:34:58
双异丙酚 - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
chromatographic conditions and system suitability test
silica gel was bonded with OCTA alkyl silane as filler; Sodium dihydrogen phosphate solution (2.76g of sodium dihydrogen phosphate monohydrate was added with 85% water to dissolve, pH was adjusted to 3.0 with phosphoric acid, and diluted to ML with water) as the mobile phase A, acetonitrile was used as the mobile phase B; The flow rate was 1.0ml per minute, the detection wavelength was 275mn, the column temperature was 40 ° C., and the gradient elution was carried out according to the following table. The appropriate amount of propofol reference substance and impurity II reference substance was taken, dissolved and diluted with methanol to prepare a mixed solution containing about 3UG of propofol and impurity II per 1 ml, which was used as a system applicable solution. 10u1 was injected into the liquid chromatograph, and the chromatogram was recorded. The resolution between propofol peak and impurity II peak should meet the requirements.
assay
take this product, weigh it precisely, add methanol to dissolve and quantitatively dilute to prepare a solution containing about 3mg of propofol per 1 ml, shake it well, and use it as a test solution, 10u1 was injected into the liquid chromatograph accurately, and the chromatogram was recorded. Another propofol reference substance was taken and determined by the same method. According to the external standard method to calculate the peak area, that is.
Last Update：2022-01-01 11:34:59
双异丙酚 - Category
Authoritative Data Verified Data
intravenous anesthetics.
Last Update：2022-01-01 11:34:59
双异丙酚 - Storage
Authoritative Data Verified Data
nitrogen filling, light shielding, sealing, storage below 15°C.
Last Update：2022-01-01 11:35:00
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