利多卡因
Lidocaine
CAS: 137-58-6
Molecular Formula: C14H22N2O
利多卡因 - Names and Identifiers
| Name | Lidocaine |
| Synonyms | Xylocaine Maricaine Lidocaine Lignocaine Ligoncaine 2-diethylaminoacet-2,6-xylidide 6'-acetoxylidide,2-(diethylamino)-2 2-(Diethylamino)-2',6'-acetoxylidide 2-(diethylamino)-2',6'-acetoxylidide 2',6'-Acetoxylidide, 2-(diethylamino)- 2-(diethylamino)-n-(2,6-dimethylphenyl)-acetamid 2-(Diethylamino)-N-(2,6-dimethylphenyl)-acetamide Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)- N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide 2-[(2,6-dimethylphenyl)amino]-N,N-diethyl-2-oxoethanaminium |
| CAS | 137-58-6 |
| EINECS | 205-302-8 |
| InChI | InChI=1/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)/p+1 |
| InChIKey | NNJVILVZKWQKPM-UHFFFAOYSA-N |
利多卡因 - Physico-chemical Properties
| Molecular Formula | C14H22N2O |
| Molar Mass | 234.34 |
| Density | 0.9944 (rough estimate) |
| Melting Point | 66-69°C |
| Boling Point | bp4 180-182°; bp2 159-160° |
| Flash Point | 9℃ |
| Water Solubility | practically insoluble |
| Solubility | ethanol: 4mg/mL |
| Vapor Presure | 4.28E-05mmHg at 25°C |
| Appearance | powder |
| Color | White to slightly yellow |
| Merck | 14,5482 |
| pKa | pKa 7.88(H2O)(Approximate) |
| Storage Condition | Store at RT |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.5110 (estimate) |
| Physical and Chemical Properties | White needle-like crystals. Melting point 68-69 ℃; Boiling point 180-182 ℃(0.53kPa),159-160 ℃(0.267kPa) soluble in ethanol, ether, benzene, chloroform and oil, insoluble in water. Commonly used base hydrochloride, lidocaine hydrochloride (C14H22N2O. HCL,[73-78-9]) is a white crystalline powder. Melting point 127-129 °c, melting point of the monohydrate 77-78 °c. Very soluble in water, 0.5% aqueous pHO 4.0-5.5. Odorless, with bitter and Hemp taste. |
| Use | Used as a local anesthetic |
利多卡因 - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S7 - Keep container tightly closed. |
| UN IDs | 3249 |
| WGK Germany | 3 |
| RTECS | AN7525000 |
| HS Code | 29242990 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 oral in rat: 317mg/kg |
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