γ-Picoline
4-Picoline
CAS: 108-89-4;51010-00-5
Molecular Formula: C6H7N
γ-Picoline - Names and Identifiers
| Name | 4-Picoline |
| Synonyms | ba35846 4-PICOLINE picoline-4 γ-Picoline p-Picoline 4-Picoline sigma-Picoline 4-Methylpyridine 4-METHYLPYRIDINE p-Methylpyridine 4-methyl-pyridine 4-methyl pyridine Pyridine,4-methyl- 4-picoline (gamma) para-Methylpyridine gamma-Methylpyridine PicolineMethylpyridine |
| CAS | 108-89-4 51010-00-5 |
| EINECS | 203-626-4 |
| InChI | InChI=1/C6H7N/c1-6-2-4-7-5-3-6/h2-5H,1H3 |
| InChIKey | FKNQCJSGGFJEIZ-UHFFFAOYSA-N |
γ-Picoline - Physico-chemical Properties
| Molecular Formula | C6H7N |
| Molar Mass | 93.13 |
| Density | 0.957 g/mL at 25 °C (lit.) |
| Melting Point | 2.4 °C (lit.) |
| Boling Point | 145 °C (lit.) |
| Flash Point | 134°F |
| Water Solubility | soluble |
| Solubility | alcohol: soluble(lit.) |
| Vapor Presure | 4 mm Hg ( 20 °C) |
| Vapor Density | 3.2 (vs air) |
| Appearance | Liquid |
| Color | Clear light yellow |
| Odor | Obnoxious, Sweetish |
| Merck | 14,7402 |
| BRN | 104586 |
| pKa | 6.02(at 20℃) |
| Storage Condition | Store below +30°C. |
| Sensitive | Air Sensitive & Hygroscopic |
| Explosive Limit | 1.3-8.7%(V) |
| Refractive Index | n20/D 1.504(lit.) |
| Physical and Chemical Properties | Colorless, flammable, volatile liquid. Has an unpleasant sweet taste. The impurity is brown. melting point 3.7 ℃ boiling point 144.9 ℃ relative density 0.9558 refractive index 1.5037 flash point 56.7 ℃ soluble in water, ethanol and ether. |
| Use | For the pharmaceutical industry |
γ-Picoline - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R10 - Flammable R20/22 - Harmful by inhalation and if swallowed. R24 - Toxic in contact with skin R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 1992 3/PG 3 |
| WGK Germany | 1 |
| RTECS | UT5425000 |
| TSCA | Yes |
| HS Code | 29333955 |
| Hazard Class | 3 |
| Packing Group | III |
| Toxicity | LD50 orally in rats: 1.29 g/kg (Smyth) |
γ-Picoline - Nature
Open Data Verified Data
colorless, flammable, volatile liquid. Has an unpleasant sweet taste. The impurity is brown. Soluble in water, ethanol and ether. The relative density was 0. 9558. Boiling point 144.9 °c. Melting point 3.7 °c. Refractive index 5037. Flash point 56.7 °c.
Last Update：2025-06-10 22:55:16
γ-Picoline - Preparation Method
Open Data Verified Data
- acetaldehyde method is obtained by condensation of acetaldehyde and ammonia in the presence of Al2 03 -Si02 catalyst.
- The acetylene method is obtained by condensation of acetylene and ammonia in the presence of a ZnS04 -H3 803 -Alz 03 catalyst, and the reaction product is refined to obtain a finished product.
Last Update：2022-01-01 10:53:08
γ-Picoline - Application
Open Data Verified Data
is generally used as a solvent. In the pharmaceutical industry, isoniazid (ramipril), which is used to manufacture the tuberculosis drug, can also be used to prepare accelerators, pesticides, dyes, reagents and catalysts.
Last Update：2025-08-19 16:24:40
γ-Picoline - Safety
Open Data Verified Data
- toxic, rat oral LD50 1.3g/kg. See pyridine for protection methods.
- packaged in iron drum. 200kg per barrel. Packing should be tight to prevent leakage. Store in a cool, dry place. According to the provisions of the storage and transportation of toxic chemicals.
Last Update：2022-01-01 10:53:08
γ-Picoline - Reference Information
| LogP | 1.22 at 25℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| uses | used in the pharmaceutical industry used in the production of drugs isoniazid, double phosphorus and double phosphorus, it is also used in the production of pesticides, dyes, rubber auxiliaries and synthetic resins. used as solvent, also used in resin synthesis and dye manufacturing |
| production method | is prepared from synthesis method and recovery from by-products of coal coking. 2-methyl pyridine and 4-methyl pyridine are mainly formed by the reaction of acetaldehyde and ammonia. Ammonia is preheated to 450 ° C., mixed with acetaldehyde after gasification, and reacted at 410-430 ° C. Through a fluidized reaction tower with aluminum silicate catalyst preheated to 430 ° C., the generated gas is separated, the obtained reaction solution was condensed and put into a dehydration pan, and 2% Solid alkali was added thereto, followed by reflux dehydration at 92 ° C. For 2H. The mixture was left to stand and separated into layers and fractionated, and the fraction at 142 ° C. And 144 ° C. Was collected to obtain 4-methylpyridine. The yield was 20% in terms of acetaldehyde (2-methylpyridine in the 125-130 °c fraction). Raw material consumption quota: liquid ammonia 1174kg/t, acetaldehyde 3019kg/t. |
| category | flammable liquid |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50: 1290 mg/kg; Abdominal injection-mouse LD50: 335 mg/kg |
| stimulation data | Skin-rabbit 10 mg/24 h; eye-rabbit 20 mg/24 h moderate |
| flammability hazard characteristics | flammable in open flame, high temperature, strong oxidant; thermal decomposition of toxic nitric oxide gas |
| storage and transportation characteristics | The package is complete, light, light; The warehouse is ventilated, away from open flame, high temperature, and oxidant, separate storage of acid |
| fire extinguishing agent | foam, carbon dioxide, dry powder, sand |
| spontaneous combustion temperature | 1000 ° F. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:04:16
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