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t-Boc-N-Amido-PEG3-propargyl

t-Boc-N-Amido-PEG3-propargyl

CAS: 1333880-60-6

Molecular Formula: C14H25NO5

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t-Boc-N-Amido-PEG3-propargyl - Names and Identifiers

Name t-Boc-N-Amido-PEG3-propargyl
Synonyms Propargyl-PEG3-NHBoc
Boc-NH-PEG3-propargyl
Boc-N-Amido-PEG3-Alkyne
t-Boc-N-Amido-PEG3-propargyl
tert-Butyl (2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl)carbamate
5,8,11-Trioxa-2-azatetradec-13-ynoic acid, 1,?1-?dimethylethyl ester
CAS 1333880-60-6

t-Boc-N-Amido-PEG3-propargyl - Physico-chemical Properties

Molecular FormulaC14H25NO5
Molar Mass287.35
Density1.045±0.06 g/cm3(Predicted)
Boling Point386.4±32.0 °C(Predicted)
pKa12.22±0.46(Predicted)

t-Boc-N-Amido-PEG3-propargyl - Upstream Downstream Industry

Raw Materials5,8,11-Trioxa-12-thia-2-azatridecanoic acid, 1,1-dimethylethyl ester, 12,12-dioxide
2-[2-(2-AZIDOETHOXY)ETHOXY]ETHANOL
2-(2-BOC-AMINOETHOXY)ETHANOL
(2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
2-[2-(2-AMINOETHOXY)ETHOXY]ETHANOL
3-Bromopropyne
Propargyl alcohol
Di-tert-butyl dicarbonate
2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL

t-Boc-N-Amido-PEG3-propargyl - Introduction

t-Boc-N-Amido-PEG3-propargyl(t-Boc-N-Amido-PEG3-propargyl) is a chemical reagent that has some of the following properties and uses:

Nature:
-Appearance: colorless or light yellow liquid
-molecular formula: C22H39NO8
-Molecular weight: 453.57g/mol
-Melting Point: N/A
-Boiling point: 400 ° C (desorption)
-Solubility: Soluble in regular organic solvents (such as methanol, ethanol, dimethyl sulfoxide, etc.), insoluble in water.

Use:
-As a protecting group in polypeptide synthesis and chemical biology, it is used to protect the α-amino group of amino acids or peptides.
-Used as a propyne functionalizing reagent in the synthesis of peptides, proteins and antibody drugs.
-In chemical reactions, it can be used as a starting reagent for mounting the PEG chain to improve the solubility and stability of biologically active molecules.

Method:
t-Boc-N-Amido-PEG3-propargyl synthesis methods are more diverse, but a common synthetic route is as follows:
1. Esterification of N-tert-butoxycarbonylidenetrimethylalanine tert-butyl ester with activated polyethylene glycol (PEG) to form a hydrophilic segment of PEG protected by N-acyl.
2. Through the nucleophilic substitution reaction, the tert-butoxycarbonyl subunit is converted into the tert-butoxycarbonyl (Boc) group of the protected amino acid.
3. The propyne functional group is introduced into the hydrophilic segment of PEG. The method can be nucleophilic substitution reaction or electrophilic substitution reaction.
4. Finally, the t-Boc-N-Amido-PEG3-propargyl is obtained through appropriate separation and purification processes.

Safety Information:
t-Boc-N-Amido-PEG3-propargyl are chemical reagents that need to be used and stored correctly to ensure safety. Observe the following safety measures:
-Avoid direct contact with skin, eyes and mucous membranes. Wear appropriate personal protective equipment such as lab gloves and goggles when using.
-During use and storage, Please maintain a well-ventilated laboratory environment.
-Avoid inhaling gases, vapors, spray or dust. If breathing discomfort occurs, discontinue use and seek medical help.
-When storing, keep it in an airtight container, away from fire sources and combustible materials.
-Follow local waste disposal regulations when handling and discarding.
Last Update:2024-04-09 21:00:56
t-Boc-N-Amido-PEG3-propargyl
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Shanghai Macklin Biochemical Co., Ltd
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Shanghai Macklin Biochemical Co., Ltd
Featured ProductsSpot supply
Product Name: tert-Butyl (2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl)carbamate Visit Supplier Webpage Request for quotation
CAS: 1333880-60-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
Shanghai Amole Biotechnology Co., Ltd.
Spot supply
Product Name: tert-Butyl(2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl)carbamate Request for quotation
CAS: 1333880-60-6
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365 Click to send a QQ message
Wechat: 18916960931
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: t-Boc-N-Amido-PEG3-propargyl Visit Supplier Webpage Request for quotation
CAS: 1333880-60-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
MedChemExpress (MCE)
Spot supply
Product Name: Boc-NH-PEG3-propargyl Visit Supplier Webpage Request for quotation
CAS: 1333880-60-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
     tech@medchemexpress.com
Mobile: 609-228-6898
View History
t-Boc-N-Amido-PEG3-propargyl
Raw Materials for t-Boc-N-Amido-PEG3-propargyl
5,8,11-Trioxa-12-thia-2-azatridecanoic acid, 1,1-dimethylethyl ester, 12,12-dioxide
2-[2-(2-AZIDOETHOXY)ETHOXY]ETHANOL
2-(2-BOC-AMINOETHOXY)ETHANOL
(2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
Di-tert-butyl dicarbonate
2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL
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