sciadopitysin
Sciadopitysin
CAS: 521-34-6
Molecular Formula: C33H24O10
sciadopitysin - Names and Identifiers
sciadopitysin - Physico-chemical Properties
| Molecular Formula | C33H24O10 |
| Molar Mass | 580.54 |
| Density | 1.445±0.06 g/cm3(Predicted) |
| Melting Point | 296-298°C |
| Boling Point | 839.6±65.0 °C(Predicted) |
| Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents |
| Appearance | Powder |
| pKa | 6.16±0.40(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD00017448 |
| Physical and Chemical Properties | White crystal, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Ginkgo biloba, Taxus branches and leaves. |
| In vitro study | Sciadopitysin (2.5, 5, 10 μM ) strongly reduces RANKL-induced osteoclast-specific genes expression, including cathepsin K (CTSK), tartrate-resistant acid phosphatase (TRAP) and MMP-9. Furthermore, Sciadopitysin apparently attenuates RANKL-increased expressions of c-Fos and NFATc1. |
| In vivo study | Sciadopitysin (i.p.; 10 mg/kg; every other day for 8 days) can reverse the bone loss in LPS-induced mice model (C57BL/6 mice; 6 weeks old). |
sciadopitysin - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29329990 |
sciadopitysin - Reference
| Reference Show more | 1. Huang Chuanjun, Li Xiao, Hu Liangliang. Analysis of annual changes of five flavonoids in Taxus chinensis var. Mairei from Zhongxiang, Hubei province [J]. Chinese Journal of Hospital Pharmacy, 2018, 38(17):21-24 33. 2. [IF = 7.514] Jie Meng et al."Conduction of a chemical structure-guided pulmonary phenotype analysis method targeting phenpropane pathway via LC-MS: Ginkgo bilba and soy bean as examples." FOOD CHEMISTRY. 2022 Oct;390:133155 |
sciadopitysin - Reference Information
| Plant Source: | ginkgo biloba |
| Use | The Golden Pine biflavone (scidopitysin) is one of the unique components of Ginkgo biloba leaves, which has good anti-inflammatory, anti-tumor cell, scavenging free radicals and other effects. Ginkgo (Ginkgo bilba L) is a plant of the genus Ginkgo family, which is a unique tree species in China, also known as Ginkgo, and is one of the most ancient Mesozoic relict rare plants, there is a gymnosperm "living fossil. Jinsong biflavone has anti-microbial, anti-tumor, anti-inflammatory, anti-immune effects. for content determination/identification/pharmacological experiments, etc |
| biological activity | scidopitysin is a biflavonoid derived from the leaves of Ginkgo biloba. Scidopitysin inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and nfatc1. |
Last Update：2024-04-09 21:54:55
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