ononin
ononin
CAS: 486-62-4
Molecular Formula: C22H22O9
ononin - Names and Identifiers
| Name | ononin |
| Synonyms | Ononin ononin Formononetin glucoside GLUCOSYL-7-O-FORMONONETIN FORMONONETIN-7-O-GLUCOSIDE ForMononetin-7-O-β-D-glucoside 4',7-DIHYDROXY-7-O-GLUCOSYLISOFLAVONE Formononetin-7-O-beta-D-glucopyranoside FORMONONETIN-7-O-BETA-D-GLUCOPYRANOSIDE 4'-METHOXYISOFLAVONE-7-O-BETA-D-GLUCOPYRANOSIDE 4'-Methoxyisoflavone-7-O-beta-D-glucopyranoside 3-(4-methoxyphenyl)-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside 4H-1-Benzopyran-4-one, 7-(beta-D-glucopyranosyloxy)-3-(4-methoxyphenyl)- |
| CAS | 486-62-4 |
| InChI | InChI=1/C22H22O9/c1-28-12-4-2-11(3-5-12)15-10-29-16-8-13(6-7-14(16)18(15)24)30-22-21(27)20(26)19(25)17(9-23)31-22/h2-8,10,17,19-23,25-27H,9H2,1H3/t17-,19-,20+,21-,22-/m1/s1 |
| InChIKey | MGJLSBDCWOSMHL-JQQDRUSQSA-N |
ononin - Physico-chemical Properties
| Molecular Formula | C22H22O9 |
| Molar Mass | 430.4 |
| Density | 1.482±0.06 g/cm3(Predicted) |
| Melting Point | 216°C |
| Boling Point | 697.8±55.0 °C(Predicted) |
| Flash Point | 245.7°C |
| Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents. |
| Vapor Presure | 1.94E-20mmHg at 25°C |
| Appearance | White crystalline powder |
| Color | Off-White |
| Maximum wavelength(λmax) | 302nm(MeOH)(lit.) |
| BRN | 63067 |
| pKa | 12.71±0.70(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Stability | Hygroscopic |
| Refractive Index | 1.655 |
| MDL | MFCD00017464 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from Astragalus, licorice. |
ononin - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 2938900000 |
ononin - Reference
| Reference Show more | 1. Wang, Wei, Zhang, Lu, Yang, Zhao, Zilong, et al. Inhibitory effect of spinetin on proliferation and migration of glioma cells [J]. Modern medical oncology 2018. 2. Ouyang Luo Dan, Xiao Su-ping, Shang Xing Pu, etc. Improvement of TLC identification method for radix astragali [J]. Modern Chinese medicine, 2019, v.21(12):38-43. 3. Zhang Ning, Gao Xia, Zhou Yu, et al. Rapid analysis of chemical constituents in Xingbei Zhike granules by UPLC-Q-TOF-MS/MS [J]. Chinese Journal of Traditional Chinese Medicine, 2018, 43(22):4439-4449. 4. Shi Yan, Xiong Yan, Wei Feng, et al. HPLC retention time prediction based on machine learning and external "probe" strategy [J]. Journal of Pharmaceutical Analysis, 2019, 39(04):160-165. 5. Shi Xiaoqian, He Ling, Liu Xue, etc. Study on HPLC fingerprint of Xin'an Mingfang naoluoxintong [J]. Journal of Liaoning University of Traditional Chinese Medicine, 2020, v.22;No.191(03):40-44. 6. Qu Ling, Tang Zhen, Su Chunlan, etc. Optimization of extraction conditions of flavonoids from cattle Boli [J]. Laboratory Quarantine, 2020, 030(002): p. 78-80. 7. Liu Xueshi Xiaoqian Wu Yanjie et al. Simultaneous determination of five active components in naoluoxintong, Xinan Mingfang, by UPLC [J]. Journal of Guiyang College of Traditional Chinese Medicine, 202042 Vol. 4, pp. 26-31. ISTIC 2020. 8. Zhang Huiping, Cai Lixia, Yu Wenshuai. UPLC study on the effect of anti-drug of Glycyrrhiza uralensis Bunge on the content of effective components in Glycyrrhiza uralensis after compatibility [J]. Journal of Shenyang Pharmaceutical University 2019. 9. Li, yingqiong, Cai, qingqun, Su, Zhiqiang et al. Comparison and cluster analysis of four isoflavones in roots, stems and leaves of Astragalus membranaceus from different habitats [J]. Modern Chinese medicine research and practice 2020 v.34;No.173(02):69-73. 10. Shang Xing Pu, Ouyang Luo Dan, Xiao Su Ping, Wang Jiyong, Gao Yongjian, Yuan Chunping, Liu Chang. Discussion on quality evaluation and grading standard of radix astragali decoction pieces [J]. Modern Chinese medicine, 2020,22(05):772-779. 11. Houmeiru, Yin Yiyi, Wang Yan, et al. Comparative study on the content and fingerprint of flavonoids in astragalus before and after fermentation [J]. Chinese Journal of Veterinary Medicine, 2018, v.52(05):52-58. 12. Li Xin, Zhuo Bing Yu, Qi Xiaojuan, etc. Grey correlation degree and path analysis of Astragalus isoflavone content and climate factors [J]. Chinese Journal of Traditional Chinese Medicine, vol. 45, 2020, 14, pp. 3340-3413, MEDLINE ISTIC PKU CSCD CA BP, 2020. 13. Mao Wendian, Li Lingling, Qi Wense, Su Zhizhi, Deng Changqing, Zhou Long. Effect of different compatibility of radix astragali and radix angelicae sinensis on the dissolution of six main effective components [J]. Journal of Hunan University of Traditional Chinese Medicine, 2021,41(03):350-354. 14. Tang Ming, Gao Xia, Geng Ting, Wang Jia Jia, Chen Xia Lin, Cao Liang, Wang Zhenzhong, Xiao Wei. Analysis of chemical components of Qiwei Tongbi oral liquid based on HPLC-Q-TOF-MS/MS Technology [J]. Chinese herbal medicine, 2021,52(08):2226-2236. 15. Tian Wancang. Identification characteristics and quality and yield difference analysis of Astragalus membranaceus in Zizhou with different growth years and harvest periods [D]. Beijing University of Chinese Medicine, 2020. 16. Zhang Li, bianxiaokun, Zhao qiulong, Qian Dawei, Guo Sheng, Yan Hui, Ouyang Zhen, Zhao Jianjun, Duan Jinyan. Modern drying and processing method of radix astragali in producing area based on multi-component [J]. Modern Chinese medicine, 2020,22(10):1684-1688. 17. [IF = 5.81] Zhang Jing et al."Chemical Analysis and Multi-Component Determination in Chinese Medicine Preparation Bupi Yishen Formula Using Ultra-High Performance Liquid Chromatography With Linear Ion Trap-Orbitrap Mass and Triple-Quadrupole Tandem Mass 18. [IF = 4.411] Liangliang Liu et al."Rapid Screening and Identification of BSA Bound Ligands from Radix astragali Using BSA Immobilized Magnetic Nanoparticles Coupled with HPLC-MS."Molecules. 2016 Nov;21(11):1471 19. [IF=3.935] Ling He et al."Using 3D-UPLC-DAD and a new method-verification by adding mixture standard compounds to determine the fingerprint and eight active components of Naoluoxintong decoction."J Pharmaceut Biomed. 2019 May;169:60 20. [IF=5.81] Gu Junfei et al."Standardized Astragalus Mongholicus Bunge-Curcuma Aromatica Salisb. Extract Efficiently Suppresses Colon Cancer Progression Through Gut Microbiota Modification in CT26-Bearing Mice."Front Pharmacol. 2021 Aug;0:2278 21. [IF=5.455] Zhang Xian et al."Neurobehavioral alternations of the female offspring born to polycystic ovary syndrome model rats administered by Chinese herbal medicine."Chin Med-Uk. 2021 Dec;16(1):1-19 22. [IF=4.879] Yang Liu et al."UV-B Radiation Largely Promoted the Transformation of Primary Metabolites to Phenols in Astragalus mongholicus Seedlings."Biomolecules. 2020 Apr;10(4):504 23. [IF=4.759] Wenjie Wu et al."An analytical strategy for accurate, rapid and sensitive quantitative analysis of isoflavones in traditional Chinese medicines using ultra-high performance supercritical fluid chromatography: Take Radix Puerariae as an example."J Chromato 24. [IF=4.411] Liyu Luo et al."Integrated Phytochemical Analysis Based on UPLC-MS and Network Pharmacology Approaches to Explore the Quality Control Markers for the Quality Assessment of Trifolium pratense L.."Molecules. 2020 Jan;25(17):3787 25. [IF=4.142] Hu Guizhou et al."An integrated strategy for the identification and screening of anti-allergy components from natural products based on calcium fluctuations and cell extraction coupled with HPLC-Q-TOF-MS."Anal Bioanal Chem. 2021 Oct;413(25):6253-6266 26. [IF=3.361] Lin Sun et al."Rapid characterization of chemical constituents of Shaoyao Gancao decoction using UHPLC coupled with Fourier transform ion cyclotron resonance mass spectrometry."Rsc Adv. 2020 Aug;10(49):29528-29535 27. [IF=7.553] Lu Zhao et al.Multimodal Identification by Transcriptomics and Multiscale Bioassays of Active Components in Xuanfeibaidu Formula to Suppress Macrophage-Mediated Immune Response.Engineering-Prc. 2021 Nov;: 28. [IF=4.36] Yule Wang et al."Synergy of “Yiqi” and “Huoxue” components of QishenYiqi formula in ischemic stroke protection via lysosomal/inflammatory mechanisms."JOURNAL OF ETHNOPHARMACOLOGY. 2022 Jul;293:115301 |
ononin - Reference Information
| biological activity | Ononin is an isoflavone that inhibits the growth of hybrid Pluchea lanceolata in soil. |
| chemical properties | white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from astragalus and licorice. |
| use | mangononine has anti-tumor effect. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: It has certain anti-cancer effects and estrogen effects?, commonly used as a diuretic clinically. |
Last Update：2024-04-09 21:01:54
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