nefopam
3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene
CAS: 13669-70-0
Molecular Formula: C17H19NO
nefopam - Names and Identifiers
nefopam - Physico-chemical Properties
| Molecular Formula | C17H19NO |
| Molar Mass | 253.34 |
| Density | 1.0078 (rough estimate) |
| Boling Point | 396.54°C (rough estimate) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.5400 (estimate) |
| Physical and Chemical Properties | Chemical properties Its hydrochloride is white crystalline powder. Melting point 238-242 ℃. Soluble in water, chloroform and methanol. It tastes bitter. |
| Use | Uses this strain of non-addictive analgesics, with muscle relaxant effect. Suitable for all kinds of postoperative pain, cancer pain, visceral smooth muscle colic, etc. For postoperative pain, cancer pain, acute external pain treatment, also suitable for acute gastritis, biliary ascariasis, ureteral calculi and other visceral smooth muscle colic |
nefopam - Upstream Downstream Industry
nefopam - Uses and synthesis methods
use
Pingtongxin (nefopam, Nefopam), the chemical name is 5-methyl -1-phenyl -3,4,5, 6-tetrahydro-1H-2, 5-oxynitrogen benzoxine, It is a non-narcotic analgesic first synthesized by Klohs et al. in 1972. Subsequently, the drug was widely used in Europe, North America, South America and other countries.
production method
The reaction of 2-benzoylbenzoic acid with thionyl chloride, and then with 2-methylaminoethanol to prepare 2-[[N-(2-hydroxyethyl)-N-methyl] amine] methyl diphenylmethanol, it is heated with p-toluenesulfonic acid and benzene to evaporate the benzene, and the resulting oil is alkalized to obtain the nefopam salt.
Last Update：2024-04-10 22:29:15
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View History
nefopam
286367-76-8
Olodaterol
5-Methoxytryptamine hydrochloride
Xenol
9-ACRIDINECARBOXYLIC ACID
4-nitro-benzenethio
Hightemperature leveling agent A-10
AminePB
Vinyl n-Butyl Ether
286367-76-8
Olodaterol
5-Methoxytryptamine hydrochloride
Xenol
9-ACRIDINECARBOXYLIC ACID
4-nitro-benzenethio
Hightemperature leveling agent A-10
AminePB
Vinyl n-Butyl Ether
Raw Materials for nefopam
Thionyl chloride
p-Toluenesulfonic acid
Activated carbon
Potassium borohydride
Benzoic acid
Benzophenone
PARA TOLUENE
Benzhydrol
2-Benzoylbenzoic acid
Lithium Aluminum Hydride
p-Toluenesulfonic acid
Activated carbon
Potassium borohydride
Benzoic acid
Benzophenone
PARA TOLUENE
Benzhydrol
2-Benzoylbenzoic acid
Lithium Aluminum Hydride