methyl-beta-cyclodextrin
methyl-beta-cyclodextrin
CAS: 128446-36-6
Molecular Formula: C54H94O35
methyl-beta-cyclodextrin - Names and Identifiers
| Name | methyl-beta-cyclodextrin |
| Synonyms | MBC BETA-CYD BETA-W7 M1.8 Methyl--cyclodextrin METHYL-BETA-CYCLODEXTRIN methyl-beta-cyclodextrin Beta-Cyclodextrin Methyl Ethers beta-Cyclodextrin methyl ethers (Mixture of several Methylated) .beta.-cyclodextrin,methylethers methyl-B-cyclodextrin cell culture*tested Methyl-beta-cyclodextrin (mixture of several Methylated) 37,39,41,43,45,47,49-heptamethoxy-5,10,15,20,25,30,35-heptakis(methoxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.2~3,6~.2~8,11~.2~13,16~.2~18,21~.2~23,26~.2~28,31~]nonatetracontane-36,38,40,42,44,46,48-heptol (non-preferred name) |
| CAS | 128446-36-6 |
| EINECS | 1308068-626-2 |
| InChI | InChI=1/C56H98O35/c1-64-15-22-36-29(57)43(71-8)50(78-22)86-37-23(16-65-2)80-52(45(73-10)30(37)58)88-39-25(18-67-4)82-54(47(75-12)32(39)60)90-41-27(20-69-6)84-56(49(77-14)34(41)62)91-42-28(21-70-7)83-55(48(76-13)35(42)63)89-40-26(19-68-5)81-53(46(74-11)33(40)61)87-38-24(17-66-3)79-51(85-36)44(72-9)31(38)59/h22-63H,15-21H2,1-14H3 |
| InChIKey | YZOUYRAONFXZSI-SBHWVFSVSA-N |
methyl-beta-cyclodextrin - Physico-chemical Properties
| Molecular Formula | C54H94O35 |
| Molar Mass | 1303.3 |
| Density | 1.4g/cm3 |
| Melting Point | 180-182°C(lit.) |
| Boling Point | 1203.6°C at 760 mmHg |
| Specific Rotation(α) | +159°(25℃, c=1, H2O) |
| Flash Point | 187°C |
| Water Solubility | Soluble in water |
| Solubility | Soluble in water and soluble in organic solvents |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White to white-like powder |
| Color | White to off-white |
| Storage Condition | room temp |
| Refractive Index | 1.552 |
| MDL | MFCD00074980 |
| Use | Increase the solubility of non-polar substances, such as fatty acids, lipids, vitamins and cholesterol, used in cell culture. |
methyl-beta-cyclodextrin - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 35051000 |
methyl-beta-cyclodextrin - Reference
| Reference Show more | 1. Yu Zhan, Li Tianle, Han Dongxu et al. 2 6-dimethyl-β-cyclodextrin solubilization mechanism of daidzein [J]. Journal of Shenyang Normal University (Natural Science Edition) 2019 37(01):18-22. 2. Yang Dan, Feng Liang, Liu Jun, Zhao Jing, Li Chao, Zhu Fagen, Shao Jianguo, Jia Xiaobin, Sun E. Study on Improvement of Drug Compliance of Pudilan Anti-inflammatory Oral Liquid for Children Based on Material Property Characterization Technology [J]. World traditional Chinese medicine, 2020,15(15):2221-2227. 3. Wang, Zhendong, et al. "Effects of the anti-angiogenic carbohydrate-peptide conjugate, chitooligosaccharide-ES2 on endothelial cells and tumor-bearing mices." Carbohydrate polymers 208 (2019): 302-313.https://doi.org/10.1016/j.carbpol. 2018.12.089 4. Ren, Zhenzhen, et al. "Construction of a water-soluble and photostable rubropunctatin/β-cyclodextrin drug carrier." RSC advances 9.20 (2019): 11396-11405.10.1039/C9RA00379G 5. [IF=6.044] Zhendong Wang et al."Effects of the anti-angiogenic carbohydrate-peptide conjugate, chitooligosaccharide-ES2 on endothelial cells and tumor-bearing mice."Carbohyd Polym. 2019 Mar;208:302 6. [IF=4.471] Wei Gao et al."Transferrin receptor-targeted pH-sensitive micellar system for diminution of drug resistance and targetable delivery in multidrug-resistant breast cancer."Int J Nanomed. 2017; 12: 1047-1064 |
methyl-beta-cyclodextrin - Introduction
Among common cyclodextrin derivatives, methylated cyclodextrins have greater surface tension
Last Update：2022-10-16 17:13:06
methyl-beta-cyclodextrin - Reference Information
| traits | methyl betacyclodextrin is white powder, non-toxic, odorless and slightly sweet. |
| use | methyl betacyclodextrin is mainly used to eliminate peculiar smell, improve the stability of flavor and pigment, and enhance emulsification and moisture resistance in food manufacturing. Improving the taste of food is a good stabilizer and flavoring agent for the pharmaceutical, food and cosmetics manufacturing industries. In medicine, the solubility and bioavailability of drugs can be improved, the efficacy of drugs can be increased or the dosage can be reduced, the release rate of drugs can be adjusted or controlled, the side effects of drugs can be reduced, and the stability of drugs can be enhanced. Especially more effective for aqueous solutions of oil-soluble molecules. Increase the solubility of non-polar substances, such as fatty acids, lipids, vitamins and cholesterol, used in cell culture. Used in food, cosmetics, pesticides, daily chemical products, textile dyeing and finishing, printing, and ink. It has good viscosity reduction effect in coating thickener |
| Biological activity | Methyl-β-cyclodextrin (MβCD, Methyl-beta-cyclodextrin, M-β-CyD, Methyl-β-CD) is a cholesterol remover, mainly used to destroy lipid raft. Methyl-β-cyclodextrin can induce caspase-dependent apoptosis in PEL cells and inhibit the growth and infection of PEL cells without obvious adverse effects, showing potential effective anti-tumor activity. |
| target | TargetValue cholesterol () lipid raft () |
| Target | Value |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
Last Update：2024-04-09 15:16:39
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