isonicotinohydrazide
Isonicotinic acid hydrazide
CAS: 54-85-3
Molecular Formula: C6H7N3O
isonicotinohydrazide - Names and Identifiers
| Name | Isonicotinic acid hydrazide |
| Synonyms | INAH Isoniazid Isoniazide isonicotinohydrazide ISONICOTINYLHYDRAZIDE Isonicotinic hydrazide Pyridine-4-carbohydrazide pyridine-3-carbohydrazide 4-(hydrazinomethyl)pyridine Isonicotinic acid hydrazide Pyridine-4-carboxylic hydrazide |
| CAS | 54-85-3 |
| EINECS | 200-214-6 |
| InChI | InChI=1/C6H7N3O2/c7-9-11-6(10)5-1-3-8-4-2-5/h1-4,9H,7H2 |
isonicotinohydrazide - Physico-chemical Properties
| Molecular Formula | C6H7N3O |
| Molar Mass | 137.14 |
| Melting Point | 170-174℃ |
| Boling Point | 251.97°C |
| Water Solubility | 14 g/100 mL (25℃) |
| Solubility | Easily soluble in water, slightly soluble in ethanol, insoluble in ether. |
| Appearance | White crystal or crystalline powder |
| Storage Condition | 2-8℃ |
| Sensitive | Sensitive to light |
| Refractive Index | 1.577 |
| MDL | MFCD00006426 |
| Physical and Chemical Properties | White crystals or crystalline powders. Odorless. Taste slightly sweet after bitter. Gradual change of texture in light. The melting point was 170-173 °c. Soluble in water, ethanol-soluble, insoluble in ether. Anti-tuberculosis drugs. |
| Use | Mainly for various types of tuberculosis, can also be used for tuberculous meningitis and other extrapulmonary tuberculosis. Often need and other anti-tuberculosis drugs. |
isonicotinohydrazide - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R40 - Limited evidence of a carcinogenic effect |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
isonicotinohydrazide - Reference
| Reference Show more | 1. Zhou Zhongyuan, Cai Xinjun, Ni Jianjun. Optimization of isoniazid temperature-sensitive in situ gel formulation for pulmonary administration via fiberoptic bronchoscopy using central composite design-response surface methodology [J]. Zhejiang traumatic surgery, 2020, 025(001):145-147. 2. [IF = 4.098] Jie Liang et al."Deep learning aided quantitative analysis of anti-tuberculosis fixed-dose combined formulation." Spectrochim Acta A. 2022 Mar;269:120746 |
isonicotinohydrazide - Standard
Authoritative Data Verified Data
This product is 4-pyridinecarylhydrazide. The content of C6H7N30 shall be between 98.0% and 102.0% based on the dry product.
Last Update：2024-01-02 23:10:35
isonicotinohydrazide - Trait
Authoritative Data Verified Data
- This product is colorless crystal, white or white crystalline powder; Odorless; Light gradient quality.
- This product is soluble in water, slightly soluble in ethanol, and slightly soluble in ether.
melting point
The melting point of this product (General 0612) is 170~173 ℃.
Last Update：2022-01-01 11:54:47
isonicotinohydrazide - Introduction
No smell. The taste is slightly sweet and then bitter. Light gradient quality. Solubility: water at 25 ℃ is about 14%, water at 40 ℃ is about 26% (the aqueous solution is neutral), ethanol at 25 ℃ is about 2%, boiling ethanol is about 10%, and chloroform is about 0.1%. Almost insoluble in benzene and ether. Median lethal dose (mice, abdominal cavity) 151mg/kg ·
Last Update：2022-10-16 17:26:04
isonicotinohydrazide - Differential diagnosis
Authoritative Data Verified Data
- take about 10 mg of this product, put it in a test tube, add 2ml of water to dissolve it, and add 1 ml of ammonia silver nitrate test solution, which will cause bubbles and black turbidity, and generate a silver mirror on the wall of the test tube.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 166).
Last Update：2022-01-01 11:54:47
isonicotinohydrazide - Exam
Authoritative Data Verified Data
pH
take 0.50g of this product, Add 10ml of water to dissolve, and measure according to law (General rule 0631). The pH value should be 6.0~8.0.
clarity and color of solution
take this product l. After 10ml of water is added, the solution should be clear and colorless; If it is turbid, it should not be more concentrated compared with No. 1 turbidity standard solution (General rule 0902-method); If it is colored, with the same volume of control solution (take the colorimetric potassium dichromate solution 3.0ml should not be deeper compared with 0.10ml of cupric sulfate solution for colorimetric use, diluted to 250ml with water).
Free hydrazine
take this product, add acetone-water (1:1) to dissolve and dilute to make a solution containing about lOOmg per 1 ml, as a test solution; Take another hydrazine sulfate reference, add acetone-water (1:1) to dissolve and dilute to prepare a solution containing about 0.08mg (equivalent to 20ug of Free hydrazine) per 1 ml as a reference solution; Take appropriate amounts of isoniazid and hydrazine, acetone-water (1:1) was added, dissolved and diluted to prepare a mixed solution containing 0.08mg of isoniazid and 0.08mg of hydrazine sulfate per 1 ml, respectively, as a system-applicable solution. According to the thin layer chromatography (General 0502) test, Draw 5 u1 of each of the above three solutions, respectively point on the same silica gel G thin layer plate, with isopropanol-acetone (3:2) as the developing solvent, expand, dry, spray with ethanol preparation of p-dimethylaminobenzaldehyde solution, 15 minutes after inspection. The spot of Free hydrazine and isoniazid should be completely separated from the solution suitable for the system. The Rf value of free hydrazine is about 0.75, and the Rf value of isoniazid is about 0.56. Yellow spots shall not appear at the corresponding positions of the main spot of the test solution and the main spot of the control solution.
Related substances
take this product, add water to dissolve and dilute to make a solution containing about 0.5mg per 1ml as a test solution; Take 1ml for precision measurement, put it in a 100ml measuring flask, dilute it with water to the scale, as a control solution. According to the chromatographic conditions under the item of content determination, each lol of the test solution and the control solution is accurately weighed and injected into the human liquid chromatograph respectively, and the chromatogram is recorded to 3.5 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.35 times (0.35%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
loss on drying
take this product, dry to constant weight at 105 ℃, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
sterile
take this product, dissolve it with appropriate solvent, and treat it by membrane filtration method. Check it according to law (General rule 1101). (For aseptic dispensing)
Last Update：2022-01-01 11:54:48
isonicotinohydrazide - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
chromatographic conditions and system suitability test
silica gel bonded with eighteen alkyl silane was used as filler, and 0.02mol/L disodium hydrogen phosphate solution (adjusted to pH 6.0 with phosphoric acid)-methanol (85:15) as mobile phase; the detection wavelength was 262mn. The number of theoretical plates is not less than 4000 based on the isoniazid peak.
assay
take this product, precision weighing, adding water to dissolve and quantitatively dilute to make about O in each lml. 1 mg of the solution, as the test solution, the precise amount of 10u1 was injected into the liquid chromatograph, and the chromatogram was recorded. Another isoniazid reference substance was taken and determined by the same method. According to the external standard method to calculate the peak area, that is.
Last Update：2022-01-01 11:54:49
isonicotinohydrazide - Category
Authoritative Data Verified Data
anti-tuberculosis drugs.
Last Update：2022-01-01 11:54:49
isonicotinohydrazide - Storage
Authoritative Data Verified Data
under shading, sealed and preserved.
Last Update：2022-01-01 11:54:49
isonicotinohydrazide - Isoniazid tablets
Authoritative Data Verified Data
This product contains isoniazid (C6H7N30) should be labeled the amount of 95.0% to 105.0%.
trait
This product is white or off-white.
identification
- take an appropriate amount of fine powder of this product (about 0.lg of isoniazid), add 10ml of water, shake, filter, and the filtrate is subjected to the identification (1) Test under isoniazid, the same reaction was shown.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- take an appropriate amount of the fine powder of this product (about 50mg equivalent to isoniazid), add 10ml of ethanol, grind and dissolve, filter, evaporate the filtrate, submerge and dry under reduced pressure, and determine according to law (General rule 0402). The infrared absorption spectrum of this product should be consistent with the spectrum of the control (Spectrum set 166 Figure).
examination
- Free hydrazine take an appropriate amount of fine powder of this product, add acetone-water (1:1) to dissolve isoniazid and dilute it to make a solution containing about lOOmg of isoniazid per 1 ml, filter it, the continued filtrate was taken as the test solution. Determination according to isoniazid Free hydrazine under the terms of the method. Yellow spots shall not appear at the corresponding positions of the main spot of the test solution and the main spot of the control solution.
- relevant substances: take an appropriate amount of the fine powder of this product, add water to dissolve isoniazid and dilute it to prepare a solution containing 0.5mg of isoniazid per 1 ml, filter it, and take the continued filtrate as the test solution. Determined according to the method under isoniazid related substances. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.5 times (0.5%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
- the dissolution of this product, according to the dissolution and release determination method (General rule 0931 method), with water 1000ml as the dissolution medium, the speed is 100 rpm, according to the law, after 30 minutes, 5ml of the solution is filtered, the appropriate amount of the filtrate is accurately taken and diluted quantitatively with water to make a solution containing 10 ~ 20ug per 1 ml, the absorbance was measured at a wavelength of 0401 NM according to ultraviolet-visible spectrophotometry (General rule 307), and the elution amount of each tablet was calculated as the absorption coefficient of C6H7N30 was. The limit is 60% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 20 tablets of this product, precision weighing, fine grinding, precision weighing to take appropriate amount, add water to dissolve isoniazid and quantitatively dilute to make it contain about 0.1 mg of the solution was filtered, and the filtrate was taken as a test solution, which was measured by the method under the isoniazid content measurement item.
category
Same as isoniazid.
specification
(l)50mg (2)100mg (3)300mg (4)500mg
storage
light-shielded, sealed, and stored in a dry place.
Last Update：2022-01-01 11:54:50
isonicotinohydrazide - Isoniazid for injection
Authoritative Data Verified Data
This product is isoniazid sterile powder. The isoniazid (C6H7N30) content shall be between 95.0% and 105.0% of the label weight, calculated as the average loading.
trait
This product is colorless crystal, white or white crystalline powder.
identification
According to the identification (1) and (3) tests under isoniazid, the same reaction was shown.
examination
- the color of the solution take 5 bottles of this product, Add 10ml of water to dissolve, and the same volume of the control solution (take the colorimetric potassium dichromate solution 3.0ml and colorimetric copper sulfate solution 0.10ml, diluted with water to 250ml), not deeper. The pH value, free hydrazine and related substances shall be checked according to the method under isoniazid item, and shall comply with the regulations.
- weight loss on drying take this product, dry to constant weight at 105 ℃, and the loss reduction and reset shall not exceed 1.0% (General rule 0831).
- sterile take this product, dissolve and dilute with a suitable solvent to prepare a solution containing about 20mg per lml, and treat it by membrane filtration method and check it according to law (General rule 1101).
- others should be in accordance with the relevant provisions under injection (General Rule 0 l02).
Content determination
take the contents under the item of loading amount difference, mix evenly, weigh precisely, add water to dissolve and quantitatively dilute to make about 0 per 1 ml. The 1 mg solution was obtained as a test solution according to the method under the isoniazid content measurement.
category
Same as isoniazid.
specification
O.lg
storage
light shielding, closed storage.
Last Update：2022-01-01 11:54:50
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