ethambutol
ethambutol
CAS: 74-55-5
Molecular Formula: C10H24N2O2
ethambutol - Names and Identifiers
| Name | ethambutol |
| Synonyms | ETHAMBUTOL ethambutol (+)-s,s-ethambutol (+)-2,2-ethylenediiminodibutan-1-ol (+)-2,2-(Ethylenediimino)di-1-butanol (+)-2,2'-(ethylenediimino)di-1-butanol 2,2'-(ethane-1,2-diyldiimino)dibutan-1-ol 2'-(1,2-ethanediyldiimino)bis-(r)-1-butano (r)-2,2'-(1,2-ethanediyldiimino)bis-1-butanol (2R,2'R)-2,2'-(ethane-1,2-diyldiimino)dibutan-1-ol (+)-n,n'-bis(1-(hydroxymethyl)propyl)ethylenediamine 2,2'-(1,2-ethanediyldiimino)bis-,(r-(r*,r*))-1-butano |
| CAS | 74-55-5 |
| EINECS | 200-810-6 |
| InChI | InChI=1/C10H24N2O2/c1-3-9(7-13)11-5-6-12-10(4-2)8-14/h9-14H,3-8H2,1-2H3/t9-,10-/m1/s1 |
ethambutol - Physico-chemical Properties
| Molecular Formula | C10H24N2O2 |
| Molar Mass | 204.31 |
| Density | 1.0048 (rough estimate) |
| Melting Point | 199-204℃ |
| Boling Point | 345℃ |
| Specific Rotation(α) | D25 +13.7° (c = 2 in water) |
| Flash Point | >110°(230°F) |
| Water Solubility | Soluble in water. Also soluble in chloroform and methylene chloride |
| Vapor Presure | 3.9E-06mmHg at 25°C |
| pKa | pKa 6.6 (H2O) (Uncertain);9.5(H3O) (Uncertain) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Refractive Index | 1.4610 (estimate) |
| Physical and Chemical Properties | The melting point of 87.5-88.8 °c. Soluble in chloroform, slightly soluble in benzene, slightly soluble in water. Ethambutol hydrochloride is a white crystalline melt with a melting point of 198.5-200.3 °c (201.8-202.6). Soluble in water, slightly soluble in ethanol, difficult to dissolve in acetone, chloroform, hygroscopicity, taste slightly bitter. As a drug, its dextrorotatory bodies are used clinically. |
ethambutol - Risk and Safety
| RTECS | EL3640000 |
| Toxicity | LD50 oral in rat: 998mg/kg |
ethambutol - Reference Information
| Overview | Ethambutol is a key intermediate for the chiral anti-tuberculosis drug ethambutol hydrochloride, the latter is widely used in combination with other anti-tuberculosis drugs in the treatment of tuberculosis caused by Mycobacterium tuberculosis, can also be used in the treatment of tuberculous meningitis and atypical Mycobacterium infection. |
| biological activity | Ethambutol is an anti-mycobacterial compound that prevents cell wall formation by inhibiting arabinyl transferase activity. |
| Use | This product has anti-tuberculosis effect, and it still has inhibitory effect on commonly used anti-tuberculosis drug-resistant tuberculosis bacteria. Its antibacterial effect is weaker than that of isoniazid, and streptomycin approximation. No effect on other bacteria and fungi. used as anti-tuberculosis drug |
| production method | separation of (±) 2-aminobutanol with tartaric acid and alkalization of () 2-aminobutanol with potassium hydroxide, then it is condensed with dichloroethane to obtain ethambutol. In the course of production, ethambutol hydrochloride is produced by acidification with hydrochloric acid to pH = 2. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:11
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View History
ethambutol
69868-05-9
2-CYCLOPROPYL-N-METHYLETHANAMINE HYDROCHLORIDE
pigment red 185
Ethyl-2-chlorothoxyacetate
Mordant yellow
propylhydride
5263-02-5
2786-07-4
55403-29-7
69868-05-9
2-CYCLOPROPYL-N-METHYLETHANAMINE HYDROCHLORIDE
pigment red 185
Ethyl-2-chlorothoxyacetate
Mordant yellow
propylhydride
5263-02-5
2786-07-4
55403-29-7