dU
(2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
CAS: 109389-30-2
Molecular Formula: C39H47N4O8P
dU - Names and Identifiers
dU - Physico-chemical Properties
| Molecular Formula | C39H47N4O8P |
| Molar Mass | 730.786 |
| Storage Condition | 2-8℃ |
dU - Synthesis and application of a novel phosphoramidite monomer with RNA 3 'terminal suspension structure
Author:
Sun Yongmei , Wei Chao , true
Abstract:
RNA interference (RNAi) is a phenomenon of gene silencing caused by double-stranded RNA, in which small interfering RNA(siRNA) is one of the factors necessary for RNAi to exert its effect. Because the use of RNAi technology can specifically knock out or turn off the expression of specific genes, siRNA has become a potential drug. siRNA has a characteristic structure: 5 'phosphate and 3' hydroxyl, and has a symmetrical 2NT 3 'end suspension. The 3' Terminal overhang plays an important role in the recognition of Dicer and Ago2, the important proteins in RNA interference pathway. We designed and synthesized a novel phosphoramidite monomer with a single-stranded RNA 3 'terminal suspension structure, which maintained the RNA interference activity of siRNA as a 3' terminal suspension, at the same time, single-stranded suspensions can be used for subsequent chemical modification and detection.
Key words:
3' end suspension phosphoramidite monomer, modified
meeting name:
Chinese Chemical Society 29th Academic Annual Meeting Abstract collection -22th: Chemical biology
Meeting Time:
2014
Last Update：2024-01-02 23:10:35
dU - Study on synthesis of amino-modified phosphoramidite monomer
from VIP
Author:
Abstract:
The amino-modified phosphoramidite monomer was synthesized by using readily available 6-amino-1-hexanol, phosphorus reagent and 4-methoxytriphenylchloromethane as raw materials. Through the study of the key factors affecting the yield, the best reaction conditions were found: the ratio of materials (hydroxyl intermediate: phosphorus reagent) was 1:1.5, reaction at 25 ℃ for 3H, the yield was 86.9%. The synthetic process has the advantages of convenient operation, high yield and little pollution, and has broad market application prospect.
Key words:
6-amino-1-hexanol phosphorus reagent 4-methoxytriphenylchloromethane amino-modified phosphoramidite monomer synthesis
DOI:
CNKI:SUN:HXSS.0.2014-10-010
year:
2014
Last Update：2023-08-16 22:05:47
dU - Application of dideoxynucleoside phosphoramidite monomer containing succinamide structure in construction of anti-enzymatic cleavage artificial nucleic acid
from Palm Bridge research
Application (patent) number:
CN202010109483.4
application date:
2020-02-22
Public/Announcement Number:
CN111303227A
Public/announcement date:
2020.06.19
applicant (patent):
China University of Petroleum (East China)
inventor:
Sun Yawei , Sun Li-Mei , Wang Dong , Wang Jigan
National and provincial code:
CN370211
Abstract:
The invention discloses an application of a dideoxynucleoside phosphoramidite monomer containing a succinamide structure in the construction of an artificial nucleic acid resistant to enzymatic cleavage, and belongs to the technical field of non-natural oligonucleotide application. The terminal Group of the artificial nucleic acid is modified with the dideoxynucleoside phosphoramidite monomer containing a succinamide structure, so that the modified artificial nucleic acid has better tolerance to exonuclease; it provides a new choice for the design of nucleic acid probes with good biological stability.
Last Update：2023-08-16 22:05:47
Supplier List
Featured ProductsSpot supply
Product Name: Dmt-Du Amidite Visit Supplier Webpage Request for quotationCAS: 109389-30-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: RMA-3027 Request for quotationCAS: 109389-30-2
Tel: 0712-8899838
Email: jy6101@rmastandards.com
Mobile: 86-15787876101
QQ: 2518299249
Wechat: 15787876101
Spot supply
Product Name: (2R,3S,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl(2-cyanoethyl)diisopropylphosphoramidite Request for quotationCAS: 109389-30-2
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: DMT-dU-CE Phosphoramidite Visit Supplier Webpage Request for quotationCAS: 109389-30-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: DMT-dU-CE Phosphoramidite Visit Supplier Webpage Request for quotationCAS: 109389-30-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: 5'-O-DMT-2'-deoxyuridine-3'-CE Phosphoramidite Visit Supplier Webpage Request for quotationCAS: 109389-30-2
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: DMT-DU AMIDITE 0.25GABSINGLE Visit Supplier Webpage Request for quotationCAS: 109389-30-2
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite Request for quotation
CAS: 109389-30-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 109389-30-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: dU Phosphoramidite Visit Supplier Webpage Request for quotation
CAS: 109389-30-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 109389-30-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: Dmt-Du Amidite Visit Supplier Webpage Request for quotationCAS: 109389-30-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: RMA-3027 Request for quotationCAS: 109389-30-2
Tel: 0712-8899838
Email: jy6101@rmastandards.com
Mobile: 86-15787876101
QQ: 2518299249
Wechat: 15787876101
Spot supply
Product Name: (2R,3S,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl(2-cyanoethyl)diisopropylphosphoramidite Request for quotationCAS: 109389-30-2
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: DMT-dU-CE Phosphoramidite Visit Supplier Webpage Request for quotationCAS: 109389-30-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: DMT-dU-CE Phosphoramidite Visit Supplier Webpage Request for quotationCAS: 109389-30-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: 5'-O-DMT-2'-deoxyuridine-3'-CE Phosphoramidite Visit Supplier Webpage Request for quotationCAS: 109389-30-2
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: DMT-DU AMIDITE 0.25GABSINGLE Visit Supplier Webpage Request for quotationCAS: 109389-30-2
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite Request for quotation
CAS: 109389-30-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 109389-30-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: dU Phosphoramidite Visit Supplier Webpage Request for quotation
CAS: 109389-30-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 109389-30-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History