bradasol
domiphen bromide
CAS: 538-71-6
Molecular Formula: C22H40BrNO
bradasol - Names and Identifiers
| Name | domiphen bromide |
| Synonyms | bradoral bradonit bradasol bradosol bradosolbromide domiphen bromide dodecyldimethyl(2-phenoxyethyl)-ammoniubromide dimethyldodecyl(2-phenoxyethyl)-ammoniubromide beta-phenoxyethyldimethyldodecylammoniumbromide N,N-dimethyl-N-(2-phenoxyethyl)dodecan-1-aminium bromide |
| CAS | 538-71-6 |
| EINECS | 208-702-0 |
| InChI | InChI=1/C22H40NO.BrH/c1-4-5-6-7-8-9-10-11-12-16-19-23(2,3)20-21-24-22-17-14-13-15-18-22;/h13-15,17-18H,4-12,16,19-21H2,1-3H3;1H/q+1;/p-1 |
| InChIKey | OJIYIVCMRYCWSE-UHFFFAOYSA-M |
bradasol - Physico-chemical Properties
| Molecular Formula | C22H40BrNO |
| Molar Mass | 414.46 |
| Density | 1.1411 (rough estimate) |
| Melting Point | 117-119 °C (lit.) |
| Water Solubility | Soluble in ethanol, acetone, ethyl acetate, chloroform and water. Slightly soluble in benzene. |
| Solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| Appearance | Solid |
| Color | White to Off-White |
| Merck | 14,3415 |
| BRN | 3922742 |
| Storage Condition | Inert atmosphere,Room Temperature |
| Sensitive | Hygroscopic |
| Refractive Index | 1.5570 (estimate) |
| MDL | MFCD00011769 |
| Use | Ent medicine, can be used for oral cavity and skin Disinfection |
| In vitro study | Recombinant synthetase (ISPD) was observed to be sensitive to Domiphen Bromide (DMB) by an ISPD activity assay. The inhibitory effect of DMB on ISPD can be confirmed by the newly established high-throughput screening system and traditional enzyme kinetic analysis. |
bradasol - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | BQ2030000 |
| TSCA | Yes |
| Hazard Class | 6.1 |
| Packing Group | III |
bradasol - Standard
Authoritative Data Verified Data
This product is N, n-dimethyl-ak2-phenoxyethyl)-l-dodecanammonium bromide monohydrate. The content of C22H40BrNO shall not be less than 98.0% calculated as dry product.
Last Update：2024-01-02 23:10:35
bradasol - Trait
Authoritative Data Verified Data
- This product is white to slightly yellow Flake crystal; Odorless or micro-strip special odor; Shake the aqueous solution, the occurrence of foam.
- This product is very soluble in ethanol or chloroform, soluble in water, slightly soluble in acetone, almost insoluble in ether.
melting point
after drying at 80°C under reduced pressure for 5 hours, the product is immediately measured according to law (General rule 0612), and the melting point is 108-118°C.
Last Update：2022-01-01 14:18:57
bradasol - Introduction
Odorless or slightly smelly, slightly bitter and soap-flavored, easily soluble in ethanol and chloroform, soluble in water, almost insoluble in ether. It is prepared from brominated dodecane and phenoxyethyl dimethylamine. Commonly used domiphene bromide. It is a cationic surface active broad-spectrum fungicide, and its effect is enhanced in alkalinity.
Last Update：2022-10-16 17:26:02
bradasol - Differential diagnosis
Authoritative Data Verified Data
- Take 10mg of this product, Add 10ml of water to dissolve, add 0.5ml of eosin sodium indicator solution, and then add 100ml of water to show pink color.
- when the product is dried at 80°C for 1 hour, its infrared absorption spectrum should be consistent with that of the control (Spectrum set 299).
- Take 10ml of 1% aqueous solution of this product and 0.5ml of dilute nitric acid to generate white precipitate, which is filtered and dissolved by adding ethanol. Identify reaction of bromide in filtrate (General rule 0301).
Last Update：2022-01-01 14:18:57
bradasol - Exam
Authoritative Data Verified Data
acidity
take 0.20g of this product, add 20ml of water to dissolve, and then measure it according to law (General rule 0631). The pH value should be 5.0~7.0.
clarity and color of solution
take this product l. After adding 10ml of water to dissolve, the solution should be clear and colorless; If it is turbid, it should not be more concentrated compared with No. 2 Turbidity standard solution (General rule 0902 method 1); If it is colored, it shall not be deeper in comparison with the yellow No. 1 Standard Colorimetric solution (General rule 0901 first method).
precision content of non-quaternary ammonium compounds
take 25ml of the solution under the content determination item, and use hydrochloric acid titration solution (0.lmol/L) 10ml instead of sodium hydroxide titration solution (0.lmol/L) 10ml, the same method of operation. Calculate the difference between the volume of potassium iodate titrant (0.05mol/ L) consumed in the determination and non-quaternary ammonium titration for each lg of mephene, and shall not be greater than 0.5.
loss on drying
take this product, dry to constant weight at 80°C, weight loss shall not exceed 5.0% (General rule 0831).
ignition residue
not more than 0.1% (General rule 0841).
Last Update：2022-01-01 14:18:58
bradasol - Content determination
Authoritative Data Verified Data
take 2.0g of this product, accurately weigh it, put it in a 100ml measuring flask, add water to dissolve and dilute it to the scale, take 25ml from the precision child, put it in a separatory funnel, add chloroform 25ml and sodium hydroxide titration solution (0.1 mol/L)10ml, Add 10ml of new 5% potassium iodide solution, shake, stand still to make layers, separate the water layer and wash with chloroform shaking for 3 times, 10ml each time, remove the chloroform layer, remove the water layer into a 250ml plug Erlenmeyer flask, rinse the separatory funnel with about 15ml of water for 3 times, incorporate the eluent into the Erlenmeyer flask, add 40ml of hydrochloric acid, and let cool, titrate to light brown with potassium iodate titration solution (0.05mol/L), add 2ml of chloroform, continue titration and shake vigorously until the red color of chloroform layer disappears; 10ml of the newly prepared 5% potassium iodide solution was accurately measured, 20ml of water and 40ml of hydrochloric acid were added, and the same method was used for blank test.
for each 1 ml potassium iodate titration solution (0.05mol/L) corresponding to 41.45mg of C22H40BrNO.Last Update：2022-01-01 14:18:59
bradasol - Category
Authoritative Data Verified Data
Disinfection antiseptic.
Last Update：2022-01-01 14:18:59
bradasol - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 14:18:59
bradasol - Diafiltration pills
Authoritative Data Verified Data
This product shall contain 85.0% ~ 115.0% of the labeled amount of meifene (C22H40BrNO • H20).
trait
This product is white to slightly yellow drop pills.
identification
- take this product and test (1) and (3) under meomiphene citrate, and ask the Result
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
examination
should comply with the relevant provisions under the pill (General rule 0108).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test the sulfonated crosslinked styrene-divinylcopolymer was used as the filler and the mobile phase was methanol -0.05mol/L sodium acetate solution (80:20); the detection wavelength was 274mn. The theoretical plate number is not less than 3000 in terms of the meifene peak.
- determination of this product 20 capsules, precision weighing, and mobile phase dissolution and quantitative dilution into each lml containing 0.8 mg of meifene solution, shake, as a test solution, if necessary, filter, take 10 u1 with precision, inject human liquid chromatograph, record chromatogram; Take appropriate amount of meifene reference substance, precision weigh, the mobile phase was added to dissolve and quantitatively dilute to prepare a solution containing 0.8 mg per 1 ml as a reference solution, which was determined by the same method. According to the external standard method to calculate the peak area, the result is multiplied by 1.0434, that is.
category
The same dose of miphene.
specification
20mg
storage
light shielding, sealed storage.
Last Update：2022-01-01 14:19:00
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