bendroflumethiazide
bendroflumethiazide
CAS: 73-48-3
Molecular Formula: C15H14F3N3O4S2
bendroflumethiazide - Names and Identifiers
| Name | bendroflumethiazide |
| Synonyms | Bendrofluazide BENDROFLUMETHIAZIDE bendroflumethiazide BENDROFLUMETHIAZIDE-D5 rac Bendroflumethiazide Bendroflumethiazide (200 mg) 6-trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine,1,1 3-benzyl-3,4-dihydro-6-trifluoromethyl-1,2,4-benzothiadiazine-7-sulphonamide 1,1-dioxide 3-benzyl-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide 3-(benzyl)-1,1-diketo-6-(trifluoromethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxo-3-(phenylmethyl)-6-(trifluoromethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide |
| CAS | 73-48-3 |
| EINECS | 200-800-1 |
| InChI | InChI=1/C15H14F3N3O4S2/c16-15(17,18)10-7-11-13(8-12(10)26(19,22)23)27(24,25)21-14(20-11)6-9-4-2-1-3-5-9/h1-5,7-8,14,20-21H,6H2,(H2,19,22,23) |
bendroflumethiazide - Physico-chemical Properties
| Molecular Formula | C15H14F3N3O4S2 |
| Molar Mass | 421.41 |
| Density | 1.4711 (estimate) |
| Melting Point | 205-207°C |
| Boling Point | 602.1±65.0 °C(Predicted) |
| Flash Point | 317.9°C |
| Water Solubility | 40mg/L(room temperature) |
| Solubility | Practically insoluble in water, freely soluble in acetone, soluble in ethanol (96 per cent). |
| Vapor Presure | 1.88E-14mmHg at 25°C |
| Appearance | neat |
| Color | Crystals from MeOH/CHCl3 |
| pKa | pKa 8.53±0.05(H2O t=25 I=0.2) (Uncertain) |
| Storage Condition | Refrigerator |
| Refractive Index | 1.583 |
| Physical and Chemical Properties | White crystalline powder. Melting Point 221-223 °c (226-227 °c). Insoluble in water, chloroform, benzene, ether, soluble in acetone, ethanol. |
bendroflumethiazide - Risk and Safety
| WGK Germany | 2 |
| RTECS | DK8225000 |
| HS Code | 2935904000 |
| Toxicity | LD50 oral in mouse: > 10gm/kg |
bendroflumethiazide - Standard
Authoritative Data Verified Data
This product is 3-benzyl-6-trifluoromethyl-7-sulfonylamino-3, 4-dihydro-2h-1, 2, 4-benzothiadiazine-1, 1-dioxide. The content of C15H14F3N304S2 shall be between 98.0% and 102.0% calculated as dry product.
Last Update：2024-01-02 23:10:35
bendroflumethiazide - Trait
Authoritative Data Verified Data
- This product is white or almost white crystalline powder; Odorless.
- This product is soluble in acetone, soluble in ethanol, slightly soluble in ether, insoluble in water or chloroform; Dissolved in alkaline solution.
Last Update：2022-01-01 11:55:22
bendroflumethiazide - Differential diagnosis
Authoritative Data Verified Data
- take about 20mg of this product, put it in a small test tube, and slowly heat it with a straight fire until it is carbonized, that is, the irritant odor of sulfur dioxide occurs.
- take this product, add 0.Olmol/L sodium hydroxide solution was dissolved and diluted to prepare a solution containing about 15ug per 1 ml, which was determined by UV-Vis spectrophotometry (General 0401), there is a maximum absorption at the wavelength of 274NM and 329nm.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 173).
- This product shows the identification reaction of organic fluoride (General rule 0301).
Last Update：2022-01-01 11:55:23
bendroflumethiazide - Exam
Authoritative Data Verified Data
aromatic first amine
take 80mg of this product, precision weighing, put it in a 100ml measuring flask, add acetone to dissolve and dilute to the scale, shake well; Take 1ml for precision measurement, add 9.0ml of 1 mol/L hydrochloric acid solution, immediately add 0.10ml of 4% sodium nitrite solution, shake well, place for 1 minute, add 10% ml of 0.20 Ammonium sulfamate solution, shake well, place for 3 minutes, add 0.80 of dilute ethanol solution of 2% naphthyl ethylenediamine dihydrochloride, shake well, and place for 2 minutes (all the above operations are performed at 20°C), UV-visible spectrophotometry (General rule 0401), measured at a wavelength of 518nm absorbance, not greater than 0.11.
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).
Last Update：2022-01-01 11:55:23
bendroflumethiazide - Content determination
Authoritative Data Verified Data
take this product about 0.2g, precision weighing, add N,N-dimethylformamide 40ml dissolved, add Azo violet indicator solution 3 drops, in nitrogen flow, with sodium methoxide titration solution (O. 1 mol/L) titration to the solution is exactly blue, and the result of the titration is corrected with a blank test. Each 1 ml of sodium methoxide titration solution (0.1 mol/L) corresponds to 21.07mg of C15H14F3N3O4S2.
Last Update：2022-01-01 11:55:24
bendroflumethiazide - Category
Authoritative Data Verified Data
diuretics.
Last Update：2022-01-01 11:55:24
bendroflumethiazide - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:55:24
bendroflumethiazide - Benzathiazide tablets
Authoritative Data Verified Data
This product contains benzylfluorothiazide (C15H14F3N304S2) should be 90.0% to 110.0% of the label.
trait
This product is white tablet.
identification
take an appropriate amount of fine powder of this product (about 50mg equivalent to benzfluorothiazide), add 5ml of acetone, shake to dissolve benzfluorothiazide, filter, and evaporate the filtrate on a water bath, the residue was taken and the same reaction was shown according to the tests of identification (1) and (4) under the item of benzylfluorothiazide.
examination
Content uniformity take 1 tablet of this product, put it in mortar, grind it finely, add an appropriate amount of 0.4% sodium hydroxide solution, grind it, and transfer it to a 25ml measuring flask in portions with 0.4% sodium hydroxide solution, fully shake to dissolve benzfluorothiazide, dilute to the scale with 0.4% sodium hydroxide solution, shake well, filter, precisely measure 2ml of filtrate, put it in a 25ml measuring flask, dilute to the scale with water, shake, determine the absorbance according to the method under the content determination item, and calculate the content, should comply with the provisions (General 0941).
Others shall be in accordance with the relevant provisions under the item tablets (General rule 0101).
Content determination
Take 20 tablets of this product, precision weighing, fine grinding, precision weighing an appropriate amount (equivalent to 15mg of benzfluorothiazide), and put it in a 100ml measuring flask, add 0.4% sodium hydroxide solution and shake intermittently for 10 minutes to dissolve benzfluorothiazide, dilute to the scale with 0.4% sodium hydroxide solution, shake well, filter, Take 5ml of filtrate and put it in 50ml measuring flask, dilute with water to scale, shake well, measure absorbance at the wavelength of 274nm by UV-Vis spectrophotometry (General rule 0401), add 0.Olmol/L sodium hydroxide solution is dissolved and diluted quantitatively to make a solution containing about 15ug per lml, and the absorbance is measured and calculated by the same method.
category
Same as benzylfluorothiazide.
specification
5mg
storage
sealed storage.
Last Update：2022-01-01 11:55:25
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Mobile: +86-18621343501
QQ: 2881950922
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Tel: 609-228-6898
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