b-chlorophenetole
b-chlorophenetole
CAS: 622-86-6
Molecular Formula: C8H9ClO
b-chlorophenetole - Names and Identifiers
| Name | b-chlorophenetole |
| Synonyms | -Chlorophenetole b-chlorophenetole Phenetole, beta-chloro- (2-chloroethoxy)-benzen 1-Phenoxy-2-chloroethane benzene,(2-chloroethoxy) benzene,(2-chloroethoxy)- Benzene, (2-chloroethoxy)- 2-chloroethyl phenyl ether beta-Phenoxyethyl chloride Ether, 2-chloroethyl phenyl |
| CAS | 622-86-6 |
| EINECS | 210-757-0 |
| InChI | InChI=1/C8H9ClO/c9-6-7-10-8-4-2-1-3-5-8/h1-5H,6-7H2 |
b-chlorophenetole - Physico-chemical Properties
| Molecular Formula | C8H9ClO |
| Molar Mass | 156.61 |
| Density | 1.129g/mLat 25°C(lit.) |
| Melting Point | 28°C |
| Boling Point | 97-98°C15mm Hg(lit.) |
| Flash Point | 213°F |
| Solubility | Chloroform, Ethyl Acetate |
| Vapor Presure | 0.178mmHg at 25°C |
| Appearance | Solid |
| Color | Pale Yellow Oil to Low Melting Colorless |
| BRN | 971048 |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | n20/D 1.534(lit.) |
| Physical and Chemical Properties | Melting point 28°C boiling point 220°C refractive index 1.534 |
| Use | For the synthesis of Nefazodone and other raw materials |
b-chlorophenetole - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | UN 3265 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-21 |
| TSCA | Yes |
| HS Code | 29093090 |
b-chlorophenetole - Nature
Open Data Verified Data
Solid, melting point 28 degrees C, boiling point 217 a 220 C, 110~102 C (1.6kPa). Soluble in alcohol, ether, benzene.
Last Update：2025-06-10 22:55:16
b-chlorophenetole - Preparation Method
Open Data Verified Data
prepared by reacting phenol with dichloroethane. Phenol, sodium hydroxide solution and water were added into the autoclave, stirred evenly to form sodium phenolate solution, dichloroethane was added, the temperature was raised to 130 ℃ within 4H, the pressure was 0.75-0. 88MPa, and the reaction was carried out for 3H. It was cooled to 45 ° C., washed with alkali solution, left to stand and layered, and hydrochloric acid was added to the aqueous layer to recover excess phenol. Oil layer with water to pH value of 7, distilled off dichloroethane to get crude product, and then distillation to get this product.
Last Update：2022-01-01 10:41:33
b-chlorophenetole - Application
Open Data Verified Data
It is a medically useful intermediate of chlorpromazine.
Last Update：2025-08-19 16:24:40
b-chlorophenetole - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Uses | The intermediate of the intestinal insect repellent, the insect repellent, can react with dimethylamine to form the intermediate phenoxyethyl dimethylamine. for the synthesis of naphthalazodone and other raw materials for the synthesis of naphthalazodone and other raw materials |
| Production method | is obtained by the reaction of phenol and dichloroethane. Phenol, sodium hydroxide solution and water are added into an autoclave, stirred evenly to form sodium phenol solution, dichloroethane is added, the temperature is increased to 130 ℃ within 4 hours, the pressure is 0.75-0.88MPa, and the reaction is 3 hours. Cool to 45 ℃, add lye to wash, stand in layers, add hydrochloric acid to the water layer to recover excess phenol. The oil layer uses water to the pH value of 7, steam to remove dichloroethane to obtain crude product, and then rectify to obtain this product. |
Last Update：2024-04-09 15:16:46
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View History
b-chlorophenetole
NHD
SOLVENT BLUE 67
8007-01-0
仲丁基氯化镁
sotalol
BENZYL BETA-L-ARABINOPYRANOSIDE
4016-11-9
阿托伐醌
2349-67-9
NHD
SOLVENT BLUE 67
8007-01-0
仲丁基氯化镁
sotalol
BENZYL BETA-L-ARABINOPYRANOSIDE
4016-11-9
阿托伐醌
2349-67-9