amichin
6-methoxy-8-quinolylamine
CAS: 90-52-8
Molecular Formula: C10H10N2O
amichin - Names and Identifiers
| Name | 6-methoxy-8-quinolylamine |
| Synonyms | amichin wr15081 IFLAB-BB F1901-0147 6-methoxy-8-quinolinamin 6-methoxy-8-quinolylamine 6-methoxy-8-quinolinamine 6-methoxyquinolin-8-amine 8-amino-6-methoxyquinoline 6-Methoxy-8-aminoquinoline 6-methoxy-8-aminoquinoline 8-amino-6-methoxy-quinolin 6-Methoxy-8-amino-quinoline 6-Methoxy-8-amino quinoline 6-Methoxyquinolin-8-ylamine |
| CAS | 90-52-8 |
| EINECS | 202-001-3 |
| InChI | InChI=1/C10H10N2O/c1-13-8-5-7-3-2-4-12-10(7)9(11)6-8/h2-6H,11H2,1H3 |
amichin - Physico-chemical Properties
| Molecular Formula | C10H10N2O |
| Molar Mass | 174.2 |
| Density | 1.217±0.06 g/cm3(Predicted) |
| Melting Point | 41 °C |
| Boling Point | 137-138 °C(Press: 1 Torr) |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | Brown to Very Dark Brown Low Melting |
| pKa | 3.49±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Stability | Incompatible with strong oxidizing agents. |
| Physical and Chemical Properties | White crystal. Melting point 41 ℃, boiling point 137-138 ℃(133Pa). |
amichin - Risk and Safety
| Hazard Class | IRRITANT |
amichin - Nature
Open Data Verified Data
crystal. Melting Point 51 °c. Boiling Point (0.133kPa) 137~138 deg C.
Last Update：2024-01-02 23:10:35
amichin - Preparation Method
Open Data Verified Data
6 methoxy 8 nitroquinoline in hydrochloric acid medium with iron powder reduced to 6-methoxy -8-amino quinine hydrochloride, and then neutralized with liquid alkali to get crude product, crude product after filtration, salting out, dehydrated to obtain finished product.
Last Update：2025-06-07 19:20:19
amichin - Application
Open Data Verified Data
pharmaceutical intermediates, mainly used for the preparation of antimalarial drugs primary ammonia quinoline phosphate, malaria quinoline.
Last Update：2025-08-19 16:24:40
amichin - Safety
Open Data Verified Data
- toxic, detailed toxicity was not reported. Direct contact with the human body should be avoided during operation.
- the container should be packed in plastic bags lined with iron or wood barrels and stored in a cool and ventilated place. Protection against heat, sun and moisture. Regulation of storage and transport of chemicals.
Last Update：2025-06-10 22:55:16
amichin - Reference Information
| Use | intermediates of antimalarial drugs primaquine phosphate, pentaquine, and vivaquine. |
| production method | 6-methoxy-8-nitroquinoline is obtained by reduction with iron powder in hydrochloric acid medium and neutralization with liquid alkali. Hydrochloric acid was put into a glass-lined reaction pan, and the temperature was raised to 50 ° C., and 6-methoxy-8-nitroquinoline and iron powder were added. The whole was added at 65-70 ° C. In 3.5H, incubated for 2H, cooled and filtered to give crude 8-amino-6-methoxyquinoline hydrochloride. After salting-out purification, 8-amino -6-methoxyquinoline was precipitated by neutralization to pH 7 with dilute alkali, and the crude product was obtained by filtration and purified with toluene to obtain 8-amino-6-methoxyquinoline. The yield was 65%. Product specifications: content ≥ 65%. Raw material consumption quota: 6-methoxy-8-nitroquinoline (94%)1765kg/t, hydrochloric acid (37%)10479kg/t, iron filings (industrial) 2519kg/t. |
Last Update：2024-04-09 02:00:12
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View History
amichin
BENAZEPRIL HCL, USP STANDARD
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BENAZEPRIL HCL, USP STANDARD
105-91-9
moxalactam sodium salt
Zirconium diboride
517907-63-0
84775-52-0
Flunisolide Hemihydrate
兒茶醛
LITHIUM TETRACHLOROPALLADATE(II) N-HYDRATE