Z-Phe-DL-Ala-FMK
Z-PHE-DL-ALA-FLUOROMETHYLKETONE
CAS: 197855-65-5
Molecular Formula: C21H23FN2O4
Z-Phe-DL-Ala-FMK - Names and Identifiers
Z-Phe-DL-Ala-FMK - Physico-chemical Properties
| Molecular Formula | C21H23FN2O4 |
| Molar Mass | 386.42 |
| Density | 1?+-.0.06 g/cm3(Predicted) |
| Boling Point | 630.5±55.0 °C(Predicted) |
| Appearance | White solid |
| pKa | 11.07±0.46(Predicted) |
| Storage Condition | Inert atmosphere,2-8°C |
| In vitro study | Z-FA-FMK inhibits the degradation of fibrillar collagen by fibroblasts and osteoclasts. Z-FA-FMK inhibits LPS-induced cytokine production by inhibiting the expression of NF-kappaB-dependent genes in macrophages. In vitro experiments, Z-FA-FMK effectively blocked mitogen and IL-2 induced T cell proliferation. |
| In vivo study | In a mouse model of intranasal Pneumonia cocci infection, Z-FA-FMK significantly increased the growth of Pneumonia cocci in the lungs and blood. In severe comprehensive immunodeficient mice, Z-FA-FMK blocked Ras oncogenic tumors and respiratory virus infection of host heart tissue. |
Z-Phe-DL-Ala-FMK - Risk and Safety
| HS Code | 29145090 |
Z-Phe-DL-Ala-FMK - Reference Information
| biological activity | Z-FA-FMK ((1S)-Z-FA-FMK) is an irreversible cysteine protease inhibitor and can also inhibit Caspases. |
| target | TargetValue cysteine protease |
| Target | Value |
| in vitro study | Z-FA-FMK inhibit the degradation of fibrous collagen through fibroblasts and osteoclasts. Z-FA-FMK inhibits LPS-induced cytokine production by inhibiting the expression of NF-kappaB-dependent genes in macrophages. In vitro experiments, Z-FA-FMK effectively blocked mitogen and IL-2-induced T cell proliferation. |
| in vivo study | in a mouse model of intranasal pneumococcal infection, Z-FA-FMK significantly increased the growth of pneumococcus in the lung and blood. In severe comprehensive immunodeficiency mice, Z-FA-FMK blocked Ras carcinogenic tumors and respiratory virus infection in host heart tissues. |
Last Update：2024-04-10 22:29:15
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