Z-ASP-GLU-VAL-ASP-FLUOROMETHYLKETONE
Z-DEVD-FMK
CAS: 210344-95-9
Molecular Formula: C30H41FN4O12
Z-ASP-GLU-VAL-ASP-FLUOROMETHYLKETONE - Names and Identifiers
Z-ASP-GLU-VAL-ASP-FLUOROMETHYLKETONE - Physico-chemical Properties
| Molecular Formula | C30H41FN4O12 |
| Molar Mass | 668.66 |
| Density | 1.260±0.06 g/cm3(Predicted) |
| Boling Point | 914.2±65.0 °C(Predicted) |
| Solubility | DMSO/DMF: ≥20 mM |
| Appearance | White to slightly brown solid |
| pKa | 10.26±0.46(Predicted) |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| Physical and Chemical Properties | Bioactive Z-DEVD-FMK (Caspase-3 Inhibitor) is a specific and irreversible Caspase-3 inhibitor, which can also effectively inhibit caspase-6, caspase-7, caspase-8 and caspase-10. |
| In vitro study | Z-DEVD-FMK (1-200 μm) inhibited D4-GDI lysis and apoptosis in a concentration-dependent manner. Z-DEVD-FMK reduced ceramide-induced cardiomyocyte death and significantly inhibited caspase 3 activation. Z-DEVD-FMK (100 μm) attenuated OxyHb-induced cell shedding in cultured brain microvascular endothelial cells, reduced activity by caspase-2 and -3, abolished OxyHb-induced DNA helices, and to prevent OxyHb induced PARP cleavage. Z-DEVD-FMK (μm) blocks the MPP-induced increase in caspase-3 enzyme activity. Z-DEVD-FMK dose-dependently blocked 6-OHDA-induced apoptosis with an IC50 of 18 μm. |
| In vivo study | Z-DEVD-FMK, before and after injury, significantly reduce the apoptosis after trauma, and significantly improve the recovery of neurological function. |
Z-ASP-GLU-VAL-ASP-FLUOROMETHYLKETONE - Risk and Safety
| WGK Germany | 3 |
Z-ASP-GLU-VAL-ASP-FLUOROMETHYLKETONE - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.496 ml | 7.478 ml | 14.955 ml |
| 5 mM | 0.299 ml | 1.496 ml | 2.991 ml |
| 10 mM | 0.15 ml | 0.748 ml | 1.496 ml |
| 5 mM | 0.03 ml | 0.15 ml | 0.299 ml |
Last Update：2024-01-02 23:10:35
Z-ASP-GLU-VAL-ASP-FLUOROMETHYLKETONE - Reference Information
| biological activity | Z-DEVD-FMK (Caspase-3 Inhibitor) is a specific and irreversible Caspase-3 inhibitor that can also effectively inhibit caspase-6, caspase-7, caspase-8 and caspase-10. |
| target | TargetValue Caspase-3 |
| Target | Value |
| in vitro study | Z-DEVD-FMK (1-200 μM) inhibited D4-GDI lysis and apoptosis in a concentration-dependent manner. Z-DEVD-FMK reduced ceramide-induced myocardial cell death and significantly inhibited caspase 3 activation. Z-DEVD-FMK (100 μM) attenuated OxyHb-induced cell shedding in cultured brain microvascular endothelial cells, decreased caspase-2 and -3 activity, abolished OxyHb-induced DNA helix, and prevented OxyHb-induced PARP cleavage. Z-DEVD-FMK (100 μM) blocked MPP-induced increase in caspase-3 enzyme activity. Z-DEVD-FMK dose-dependent blockade of 6-OHDA-induced apoptosis with an IC50 of 18 μM. |
| in vivo studies | Z-DEVD-FMK, before and after injury, apoptosis after trauma was significantly reduced, and the recovery of nerve function was significantly improved. |
Last Update：2024-04-09 20:52:54
Supplier List
Featured ProductsSpot supply
Product Name: Z-DEVD-FMK Visit Supplier Webpage Request for quotationCAS: 210344-95-9
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Z-DEVD-FMK Request for quotationCAS: 210344-95-9
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Z-DEVD-FMK Visit Supplier Webpage Request for quotationCAS: 210344-95-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Z-DEVD-FMK Visit Supplier Webpage Request for quotationCAS: 210344-95-9
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Z-DEVD-FMK Visit Supplier Webpage Request for quotationCAS: 210344-95-9
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Product Name: Z-DEVD-FMK Visit Supplier Webpage Request for quotation
CAS: 210344-95-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 210344-95-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: Z-DEVD-FMK Visit Supplier Webpage Request for quotationCAS: 210344-95-9
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Z-DEVD-FMK Request for quotationCAS: 210344-95-9
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Z-DEVD-FMK Visit Supplier Webpage Request for quotationCAS: 210344-95-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Z-DEVD-FMK Visit Supplier Webpage Request for quotationCAS: 210344-95-9
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Z-DEVD-FMK Visit Supplier Webpage Request for quotationCAS: 210344-95-9
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Product Name: Z-DEVD-FMK Visit Supplier Webpage Request for quotation
CAS: 210344-95-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 210344-95-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History