YO01027
YO-01027
CAS: 209984-56-5
Molecular Formula: C26H23F2N3O3
YO01027 - Names and Identifiers
YO01027 - Physico-chemical Properties
| Molecular Formula | C26H23F2N3O3 |
| Molar Mass | 463.48 |
| Density | 1.35 |
| Melting Point | 257-259?C |
| Boling Point | 801.3±65.0 °C(Predicted) |
| Solubility | DMSO: soluble15mg/mL, clear |
| Appearance | White solid |
| Color | white to beige |
| pKa | 12.76±0.20(Predicted) |
| Storage Condition | -20°C |
| In vitro study | YO-01027 interacts directly with the gamma-secretase complex and targets the N-terminal presenilin fragment. Administration of increasing concentrations of YO-01027 to cells expressing APPL or Notch resulted in progressive accumulation of APPL CTF fragments and complete dose-dependent reduction in NICD production. 10 μm YO-01027 reduces the number and activity of breast cancer stem cells (bcscs). A recent study showed that YO-01027 inhibited mucin MUC16 biosynthesis in undifferentiated cells before and during the fusion phase in a concentration-dependent manner via Notch inhibition, however, there is no such effect in cells at different stages after mitosis. |
| In vivo study | YO-01027, intraperitoneal injection at a dose of 1 mg/ml on the day of cell injection and the following 3 days significantly reduced MCF7 tumors, but had no effect on MDA-MB-231 tumors, compared with control mice (18-28 days). It also increases the latency. YO-01027 treatment of MCF7 tumors significantly reduced tumor volume. YO-01027 treatment of C57BL/6 mice inhibited epithelial cell proliferation and dose-dependently induced goblet cell differentiation in Intestinal Adenomas. |
YO01027 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 29337900 |
YO01027 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.158 ml | 10.788 ml | 21.576 ml |
| 5 mM | 0.432 ml | 2.158 ml | 4.315 ml |
| 10 mM | 0.216 ml | 1.079 ml | 2.158 ml |
| 5 mM | 0.043 ml | 0.216 ml | 0.432 ml |
Last Update：2024-01-02 23:10:35
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Product Name: Dibenzazepine (YO-01027) Visit Supplier Webpage Request for quotationCAS: 209984-56-5
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Email: Int06@meryer.com
Mobile: +86-18821248368
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Product Name: YO-01027 Visit Supplier Webpage Request for quotationCAS: 209984-56-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Dibenzazepine; DBZ Visit Supplier Webpage Request for quotationCAS: 209984-56-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: YO-01027 Visit Supplier Webpage Request for quotationCAS: 209984-56-5
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View History
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