Xeruborbactam
Benzo[e]cycloprop[c][1,2]oxaborin-4-carboxylic acid, 5-fluoro-1,1a,2,7b-tetrahydro-2-hydroxy-, (1aR,7bS)-
CAS: 2170834-63-4
Molecular Formula: C10H8BFO4
Xeruborbactam - Names and Identifiers
Xeruborbactam - Physico-chemical Properties
| Molecular Formula | C10H8BFO4 |
| Solubility | Soluble in DMSO |
| Storage Condition | -20 ℃, dark |
| Use | QPX7728 is an ultrabroad-spectrum inhibitor of serine and metallo-β-lactamases. This compound displays a remarkably broad spectrum of inhibition, including class B and class D enzymes, and is little affected by porin modifications and efflux. QPX7728 is a promising agent for use in combination with a β-lactam antibiotic for the treatment of a wide range of multidrug resistant Gram-negative bacterial infections, by both intravenous and oral administration. |
Xeruborbactam - Reference
| Reference Show more | 1. Lomovskaya O, et al, The Impact of Intrinsic Resistance Mechanisms on Potency of QPX7728, a New Ultra-Broad-Spectrum Beta-lactamase Inhibitor of Serine and Metallo Beta-Lactamases in Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii. Antimicrob Agents Chemother. 2020 Mar 30. pii: AAC.00552-20. |
Xeruborbactam - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.505 ml | 22.525 ml | 45.049 ml |
| 5 mM | 0.901 ml | 4.505 ml | 9.01 ml |
| 10 mM | 0.45 ml | 2.252 ml | 4.505 ml |
| 5 mM | 0.09 ml | 0.45 ml | 0.901 ml |
Last Update：2024-01-02 23:10:35
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