Valcyte
Valganciclovir hydrochloride
CAS: 175865-59-5
Molecular Formula: C14H23ClN6O5
Valcyte - Names and Identifiers
| Name | Valganciclovir hydrochloride |
| Synonyms | Valcyt Valcyte Rs 079070-194 Unii-4p3T9qf9nz VALGANCICLOVIR HCL Valganciclovir hydrochloride Valganciclovir hydrochloride hydrate L-VALINE,2-[(2-AMINO-1,6-DIHYDRO-6-OXO-9H-PURIN-9-YL)METHOXY]-3-HYDROXYPROPYLESTER,MONOHYDROCHLORIDE L-VALINE, 2-[(2-AMINO-1,6-DIHYDRO-6-OXO-9H-PURIN-9-YL)METHOXY]-3-HYDROXYPROPYL ESTER, MONOHYDROCHLORIDE L-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, monohydrochloride hydrate 2-[(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)methoxy]-3-hydroxypropyl (2S)-2-amino-3-methylbutanoate hydrochloride hydrate |
| CAS | 175865-59-5 |
| EINECS | 641-360-4 |
| InChI | InChI=1/C14H22N6O5.ClH/c1-7(2)9(15)13(23)24-4-8(3-21)25-6-20-5-17-10-11(20)18-14(16)19-12(10)22;/h5,7-9,21H,3-4,6,15H2,1-2H3,(H3,16,18,19,22);1H/t8?,9-;/m0./s1 |
| InChIKey | ZORWARFPXPVJLW-MTFPJWTKSA-N |
Valcyte - Physico-chemical Properties
| Molecular Formula | C14H23ClN6O5 |
| Molar Mass | 390.82 |
| Melting Point | 162-164°C |
| Boling Point | 629.1°C at 760 mmHg |
| Flash Point | 334.3°C |
| Solubility | H2O: ≥8mg/mL |
| Vapor Presure | 1.08E-16mmHg at 25°C |
| Appearance | powder |
| Color | white to tan |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Stability | Hygroscopic |
| In vitro study | Valganciclovir hydrochloride is the hydrochloride salt of the L-valyl ester of ganciclovir, which exists as a mixture of two diastereomers. After administration, these diastereomers are rapidly converted to ganciclovir by esterases in the liver and intestine. In macrophage (CMV) infected cells, ganciclovir is first phosphorylated by viral protein agent kinases to form monophosphate, and then further phosphorylated by cellular kinases to form triphosphate. The triphosphate is slowly metabolized in the cell. The phosphorylation process is dependent on viral kinases and occurs preferentially in virus-infected cells. The inhibition of viral activity by Ganciclovir is due to the inhibition of viral DNA synthesis by ganciclovir triphosphate. Ganciclovir triphosphate integrates into the DNA strand to displace many adenosine bases. This hinders DNA synthesis, and phosphodiester bonds take longer to form, thereby weakening the stability of the chain. Ganciclovir inhibits viral DNA polymerases more effectively than cellular polymerases, and when ganciclovir is removed, chain elongation resumes. |
| In vivo study | After oral administration, intestinal and hepatic esterases hydrolyze both diastereomers of ganciclovir simultaneously, inhibiting the replication of human macrophage virus. Valganciclovir is well absorbed from the gastrointestinal tract, and the bioavailability of valganciclovir tablets (administered after meals) is about 60%. |
Valcyte - Risk and Safety
| WGK Germany | 3 |
| HS Code | 2933595960 |
Valcyte - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.559 ml | 12.794 ml | 25.587 ml |
| 5 mM | 0.512 ml | 2.559 ml | 5.117 ml |
| 10 mM | 0.256 ml | 1.279 ml | 2.559 ml |
| 5 mM | 0.051 ml | 0.256 ml | 0.512 ml |
Last Update：2024-01-02 23:10:35
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Product Name: Valganciclovirhydrochloride Request for quotationCAS: 175865-59-5
Tel: 400-968-2212
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Mobile: 18916960931
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Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
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Multiple SpecificationsSpot supply
Product Name: Valganciclovir Visit Supplier Webpage Request for quotationCAS: 175865-59-5
Tel: 609-228-6898
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tech@medchemexpress.com
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Product Name: Valganciclovir hydrochloride Visit Supplier Webpage Request for quotationCAS: 175865-59-5
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
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View History
Valcyte
p-Methylpyrocatechol
AC1L3RGI
OXALIC ACID POWDER
CCRIS 6005
cyanic chloride
NSC 12574
NSC 112222
Hydroperite
p-Methylpyrocatechol
AC1L3RGI
OXALIC ACID POWDER
CCRIS 6005
cyanic chloride
NSC 12574
NSC 112222
Hydroperite