VRT752271
4-[5-Chloro-2-[(1-methylethyl)amino]-4-pyridinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide
CAS: 869886-67-9
Molecular Formula: C21H22Cl2N4O2
VRT752271 - Names and Identifiers
VRT752271 - Physico-chemical Properties
| Molecular Formula | C21H22Cl2N4O2 |
| Molar Mass | 433.33098 |
| Density | 1.359 |
| Boling Point | 682.8±55.0 °C(Predicted) |
| Solubility | DMSO: ≥ 45 mg/mL |
| pKa | 13.34±0.50(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | In a A375 melanoma cell containing the b-RAFV600E mutant, Ulixertinib reduced the level of phosphorylated ERK2 (pERK) and the level of phosphorylation of the downstream kinase RSK (pRSK) with an IC50 of 4.1/0.14 μm, respectively. Ulixertinib also inhibited A375 cell proliferation with an IC50 of 180 nM. |
VRT752271 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.308 ml | 11.539 ml | 23.077 ml |
| 5 mM | 0.462 ml | 2.308 ml | 4.615 ml |
| 10 mM | 0.231 ml | 1.154 ml | 2.308 ml |
| 5 mM | 0.046 ml | 0.231 ml | 0.462 ml |
Last Update：2024-01-02 23:10:35
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Featured ProductsSpot supply
Product Name: Ulixertinib (BVD-523, VRT752271) Visit Supplier Webpage Request for quotationCAS: 869886-67-9
Tel: +86-18821248368
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Multiple SpecificationsSpot supply
Product Name: (S)-4-(5-Chloro-2-(isopropylamino)pyridin-4-yl)-N-(1-(3-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide Request for quotationCAS: 869886-67-9
Tel: 400-968-2212
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Mobile: 18916960931
QQ: 3623107365
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Spot supply
Product Name: Ulixertinib Visit Supplier Webpage Request for quotationCAS: 869886-67-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: BVD-523; VRT752271 Visit Supplier Webpage Request for quotationCAS: 869886-67-9
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
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Product Name: VRT752271 Visit Supplier Webpage Request for quotationCAS: 869886-67-9
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