UBCS039
UBCS039
CAS: 358721-70-7
Molecular Formula: C16H13N3
UBCS039 - Names and Identifiers
| Name | UBCS039 |
| Synonyms | UBCS039 4-(Pyridin-3-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline Pyrrolo[1,2-a]quinoxaline, 4,5-dihydro-4-(3-pyridinyl)- |
| CAS | 358721-70-7 |
UBCS039 - Physico-chemical Properties
| Molecular Formula | C16H13N3 |
| Molar Mass | 247.29 |
| Density | 1.25±0.1 g/cm3(Predicted) |
| Boling Point | 453.9±45.0 °C(Predicted) |
| pKa | 4.66±0.12(Predicted) |
| Storage Condition | 2-8°C |
| Use | UBCS039 is the first synthetic, specific activator of SIRT6 that induces autophagy in human cancer cells with an EC50 value of 38 μm. |
| In vitro study | UBCS039 (75 μM, 48 or 72 hours) induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells. UBCS039 leads to autophagosome accumulation in human cancer cells. UBCS039 induces autophagy via AMP-activated protein kinase (AMPK) signaling pathway activation. Western Blot Analysis Cell Line: Human H1299 cells. Concentration: 75 μM. Incubation Time: 48 and 72 hours. Result: Induced deacetylation of SIRT6-targeted histone H3 sites in human H1299 cells. Western Blot Analysis Cell Line: Human H1299 cells. Concentration: 75 μM. Incubation Time: 48 and 72 hours. Result: Induced deacetylation of SIRT6-targeted histone H3 sites in human H1299 cells. Cell Proliferation Assay Cell Line: Human H1299 cells. Concentration: 100 μM. Incubation Time: 48 and 72 hours. Result: Led to a strong decrease of cell proliferation in a dose-dependent manner when compared with control or DMSO-treated cells, starting from day 3 of growth (48 h after treatment) in both H1299 and HeLa cell lines. |
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