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U-67279A

Ceftiofur hydrochloride

CAS: 103980-44-5

Molecular Formula: C19H18ClN5O7S3

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U-67279A - Names and Identifiers

Name Ceftiofur hydrochloride
Synonyms U 64279A
U-67279A
Ceftiofur hcl
CEFTIOFUR HCL
Unii-6822A07436
Ceftiofur hydrochloride
CEFTIOFUR HYDROCHLORIDE
7-[(Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-(methoxy-imino)acetamido]-3-(2-furoylthiomethyl)-3-cephem-4-carboxylic acid Hydrochloride
(6R,7R)-7-[2-(2-Aminothiazol-4-yl)-2-(methylimino)actylamino] -3-[(2-furanylcarbonyl) thiomethyl]-3-cephem-4-carboxylic acid Hydrochloride
(6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[[(2-furanylcarbonyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(((2-furanylcarbonyl)thio)methyl)-8-oxo, monohydrochloride, (6R,7R)
(6r-(6alpha,7beta(z))-7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(((2-furanylcarbonyl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride
(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(furan-2-ylcarbonyl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride
CAS 103980-44-5
EINECS 600-507-2
InChI InChI=1/C19H17N5O7S3.ClH/c1-30-23-11(9-7-34-19(20)21-9)14(25)22-12-15(26)24-13(17(27)28)8(5-32-16(12)24)6-33-18(29)10-3-2-4-31-10;/h2-4,7,12,16H,5-6H2,1H3,(H2,20,21)(H,22,25)(H,27,28);1H/b23-11+
InChIKey KEQFDTJEEQKVLM-JUODUXDSSA-N

U-67279A - Physico-chemical Properties

Molecular FormulaC19H18ClN5O7S3
Molar Mass560.01
Melting Point>190°C (dec.)
Boling Point814.1°C at 760 mmHg
Specific Rotation(α)-92～-98°(D/20℃)(c=0.2,CH3OH)
Flash Point446.1°C
Solubility DMSO (Slightly), Methanol (Slightly)
Vapor Presure5.14E-28mmHg at 25°C
Appearanceneat
ColorOff-White
Storage ConditionInert atmosphere,2-8°C
UseIt is the third generation cephalosporin for animals, mainly used for the treatment of infectious diseases in pigs, cattle, horses, dogs and one-day chickens caused by sensitive bacteria
In vitro studyCeftiofur down-regulated the expression of tumor necrosis factor-α(TNF-α), interleukin-1 β(IL-1β) and interleukin-6 (IL-6), but did not affect the production of interleukin-10 (IL-10). In RAW 264.7 cells, Ceftiofur significantly inhibited the phosphorylated protein expression of extracellular signal-regulated kinase (ERK),p38 and NH(2) Terminal Kinase (JNK) of c-jun. In RAW 264.7 cells, Ceftiofur also inhibited the ectopy of p65-nf-κB to the nucleus of RAW264.7 cells.
In vivo studyIn newborn calves, Ceftiofur was associated with a significant decrease in rectal temperature and Diarrhea. In newborn calves, Ceftiofur resulted in a significant decrease in the shedding of salmonella faeces. In cows with endometritis, ceftiofurhydrotride reduced positive uterine cultures and the 51-day reduction was Prevalence Rate of the Arcanobacterium pyogenes in milk. In cows with endometritis, ceftiofurhydrotride reduced uterine infections and A. pyogenes by Prevalence Rate and did not affect endometritis and fertility by Prevalence Rate in cows that had been given PGF(2alpha). In pigs, ceftiofurhydrooride resulted in a C(max) of 11.8 mg/mL and an AUC of 216 mg xh/ mL after 1-4 hours of injection (intramuscular injection). In cows, ceftiofurhydrooride (2.2 mg CE/kg,SC or IM, once daily for 5 days) is effective in treating acute postpartum metritis (APM).

U-67279A - Risk and Safety

WGK Germany3
HS Code2941906000
U-67279A
Supplier List
Shanghai Macklin Biochemical Co., Ltd
Featured ProductsSpot supply
Product Name: (6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-(((furan-2-carbonyl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride Visit Supplier Webpage Request for quotation
CAS: 103980-44-5
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Shanghai Amole Biotechnology Co., Ltd.
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SKYRUN INDUSTRIAL CO.,LTD
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Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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Shanghai Macklin Biochemical Co., Ltd
Featured ProductsSpot supply
Product Name: (6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-(((furan-2-carbonyl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride Visit Supplier Webpage Request for quotation
CAS: 103980-44-5
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
Shanghai Amole Biotechnology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Ceftiofur Hydrochloride Request for quotation
CAS: 103980-44-5
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365 Click to send a QQ message
Wechat: 18916960931
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: Ceftiofur HCl Visit Supplier Webpage Request for quotation
CAS: 103980-44-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
MedChemExpress (MCE)
Multiple SpecificationsSpot supply
Product Name: Ceftiofur Visit Supplier Webpage Request for quotation
CAS: 103980-44-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898
SKYRUN INDUSTRIAL CO.,LTD
Spot supply
Product Name: Ceftiofur hydrochloride Visit Supplier Webpage Request for quotation
CAS: 103980-44-5
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185 Click to send a QQ messageSend QQ message
Wechat: chinaskyrun
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Ceftiofur hydrochloride Request for quotation
CAS: 103980-44-5
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Ceftiofur hydrochloride Visit Supplier Webpage Request for quotation
CAS: 103980-44-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
View History
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