| Name | Amitrole |
| Synonyms | amizol AMITROL AMIZOLE Amitrole AMITROLE AMIZOL(R) AMITROLE(R) aminotriazole AMINOTRIAZOLE Triazol-3-amine Sulfamidopyrine Amino-s-triazole Amino-1,2,4-triazole amino-1,2,4-triazole Melaminsulfone sodium 3-Amino-1,2,4-Triazole 1H-1,2,3-triazol-1-amine 1H-1,2,4-triazol-3-amine 3-Amino-1H-1,2,4-Triazole |
| CAS | 61-82-5 |
| EINECS | 200-521-5 |
| InChI | InChI=1/C2H4N4/c3-6-2-1-4-5-6/h1-2H,3H2 |
| Molecular Formula | C2H4N4 |
| Molar Mass | 84.08 |
| Density | 1.138 |
| Melting Point | 150-153°C(lit.) |
| Boling Point | 144.35°C (rough estimate) |
| Flash Point | 101.9°C |
| Water Solubility | 280 g/L (20 ºC) |
| Solubility | 280g/l |
| Appearance | Powder or Flakes |
| Color | White to off-white or yellow |
| Exposure Limit | NIOSH REL: TWA 0.2 mg/m3; ACGIH TLV: TWA 0.2 mg/m3. |
| Merck | 14,489 |
| BRN | 107687 |
| pKa | 11.14±0.20(Predicted) |
| PH | 6.4-7.4 (100g/l, H2O, 20℃) |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Incompatible with iron, copper, aluminium, acids, alkalies, strong oxidizing agents, acid chlorides, acid anhydrides. Forms chelates with some metals. Moisture sensitive. |
| Refractive Index | 1.6260 (estimate) |
| Physical and Chemical Properties | White crystals or crystalline powders. Melting point 150-153 °c. Soluble in water, slightly soluble in methanol, ethanol, insoluble in ether, acetone. |
| Use | It is used as a herbicide and is particularly suitable for use as a cotton defoliant. |
| Risk Codes | R48/22 - Harmful danger of serious damage to health by prolonged exposure if swallowed. R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R63 - Possible risk of harm to the unborn child R40 - Limited evidence of a carcinogenic effect R61 - May cause harm to the unborn child |
| Safety Description | S13 - Keep away from food, drink and animal foodstuffs. S36/37 - Wear suitable protective clothing and gloves. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S53 - Avoid exposure - obtain special instructions before use. |
| UN IDs | UN 3077 9/PG 3 |
| WGK Germany | 2 |
| RTECS | XZ3850000 |
| TSCA | Yes |
| HS Code | 29339990 |
| Hazard Class | 9 |
| Packing Group | III |
| Toxicity | LD50 in mice, rats (g/kg): 14.7, 25.0 orally (Krller) |
| Raw Materials | aminoguanidinium sulphate |
crystallization (water, ethanol or ethyl acetate),m.p.159 °c. LD50 (Rat oral) llOOmg/kg, animal experiments have carcinogenic and teratogenic effects.
there are aminoguanidine method, cyanamide hydrazine method.
This product is used as a raw material for angina pectoris and coronary artery dilator zoxadiazine (Trapidil) in medicine. In terms of dyes used in the synthesis of basicyellow 25, basicred 22,Basic blue 93, etc.
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| (IARC) carcinogen classification | 3 (Vol. 79, Sup 7) 2001 |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Use | Used as a cationic dye intermediate, it can synthesize a variety of red dyes such as cationic red X-GRL; it is also a heterocyclic intermediate, which can be used in pharmaceuticals Can be used as a pharmaceutical intermediate. It is used in the synthesis of the drug zolazepine. used as herbicide, especially suitable for cotton defoliant. |
| Production method | It is obtained by cycliding hydrazine hydrate, cyanamide, and formic acid; or by the action of aminoguanide bicarbonate and formic acid, and then heating and cycliding; It can also be obtained by using guanidine nitrate as raw material, first reacting with acetic acid at a temperature of 5-15 ℃ for 8h, then reacting with oxalic acid, and finally refluxing for 5h. |
| category | pesticide |
| toxicity classification | poisoning |
| acute toxicity | oral-rat LD50: 1100 mg/kg; Oral-mouse LD50: 14700 mg/kg |
| flammability hazard characteristics | combustion produces toxic nitrogen oxide gas |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; separate from food raw materials storage and transportation |
| fire extinguishing agent | dry powder, foam, sand |
| occupational standard | TWA 0.2 mg/m3 |
| spontaneous combustion temperature | >225°C |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |