| Name | topiramate |
| Synonyms | Topina Topimax Topamax Tracrium topiramate Topiramic acid |
| CAS | 97240-79-4 |
| EINECS | 619-263-3 |
| InChI | InChI=1/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9?,12+/m0/s1 |
| Molecular Formula | C12H21NO8S |
| Molar Mass | 339.36 |
| Density | 1.336±0.06 g/cm3(Predicted) |
| Melting Point | 125°C |
| Boling Point | 438.7±55.0 °C(Predicted) |
| Specific Rotation(α) | D23 -34.0° (c = 0.4 in methanol) |
| Flash Point | 9℃ |
| Water Solubility | 9.705g/L(temperature not stated) |
| Solubility | DMSO: 40 mg/mL |
| Vapor Presure | 6.76E-08mmHg at 25°C |
| Appearance | white solid |
| Color | white |
| Merck | 14,9547 |
| pKa | 9.22±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.497 |
| MDL | MFCD00865320 |
| Physical and Chemical Properties | Melting Point: 125°C |
| Use | Used as anticonvulsants, antiepileptic drugs |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S7 - Keep container tightly closed. |
| UN IDs | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS | LS7083000 |
| HS Code | 29350090 |
| Toxicity | LD50 intraperitoneal in rat: > 1500mg/kg |
| Reference Show more | 1. Song Wei, Chen Jinbo, Zhang Defu, ZHENG Hai Fei, Song Xiao-Wen, Dong Xiao-Meng, Lu Wen-Xian. Therapeutic effect and mechanism of gastrodin intraperitoneal injection on chronic migraine rats [J]. Shandong medicine, 2021,61(04):10-14. |