Tolclofos-Methyl
Tolclofos-Methyl
CAS: 57018-04-9
Molecular Formula: C9H11Cl2O3PS
Tolclofos-Methyl - Names and Identifiers
Tolclofos-Methyl - Physico-chemical Properties
| Molecular Formula | C9H11Cl2O3PS |
| Molar Mass | 301.13 |
| Density | 1.401±0.06 g/cm3(Predicted) |
| Melting Point | 78-80°C |
| Boling Point | 338.5±52.0 °C(Predicted) |
| Flash Point | >100°C |
| Water Solubility | 1.10 mg l-1 (25 °C) |
| Vapor Presure | 1.84 x 10-3 (Pa 25 °C) |
| Appearance | neat |
| Merck | 13,9587 |
| BRN | 2136521 |
| Storage Condition | 2-8°C |
| Refractive Index | 1.563 |
| MDL | MFCD00078741 |
| Physical and Chemical Properties | Melting Point: 78 - 80 |
| Use | Mainly used for the Prevention and Control of Soil borne diseases, such as bacterial wilt, bacterial wilt, yellow blight, suitable for cotton, rice, wheat and other crops |
Tolclofos-Methyl - Risk and Safety
| Risk Codes | R43 - May cause sensitization by skin contact R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S60 - This material and its container must be disposed of as hazardous waste. S37 - Wear suitable gloves. S24 - Avoid contact with skin. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| RTECS | TF0460000 |
| HS Code | 29201900 |
| Toxicity | LD50 in male, female rats, male, female mice (mg/kg): ~5000, ~5000, 3500, 3600 orally; all >5000 dermally; ~5000, 4900, 1070, 1260 i.p.; all >5000 s.c. (Ohtsuki, Fujinami) |
Tolclofos-Methyl - Upstream Downstream Industry
Tolclofos-Methyl - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| toxicity | Acute oral LD50 of rats is about 5000mg/kg, acute percutaneous LD50>5000mg/kg, acute inhalation LC50>1.9mg/L. No irritation to the eyes and skin. The teratogenic, carcinogenic and mutagenic effects were not found in animal experiments. The LC50 of carp was 2.13mg/L, acute oral LD50>5000mg/kg in quails and LC50>100 μg/Bee. |
| biological activity | Tolclofos-methyl is a broad-spectrum systemic fungicide, it is used for the prevention and treatment of soil-borne and seed-borne pathogens causing seed decay and seedling destruction. |
| Use | organophosphorus fungicide. It has strong bactericidal activity against all kinds of pathogenic bacteria, such as the class of the genus of the genus and the class of the fungus. It has a good killing effect on Rhizoctonia solani and Sclerotinia sclerotiorum. Application methods: toxic soil, spraying, seed dressing, maceration, soil application, etc. Such as stem and leaf spray, the dosage of 0.5 ~ 1kg per hectare; Seed treatment, the dosage of 200 ~ 300g per 50kg cotton seed. It is mainly used to control soil-borne diseases, such as bacterial wilt, bacterial wilt and yellow blight. It is suitable for cotton, rice, wheat and other crops |
| production method | 2, 6-dichloro-4-methylphenol was prepared by catalytic chlorination of p-cresol. Then, using benzyltriethylammonium bromide (TEBA) as a catalyst, 0.105mol of dichloro-p-cresol was reacted with O,O-dimethylthiophosphoryl chloride at a reaction temperature of 60-70 ° C. For 2H, a solvent of toluene and an acid binding agent of potassium carbonate. After the end of the reaction, the content of methyl phosphorus was 29.8g, the yield was 91.5%, and the content was 92.5%. There are many methods for the condensation of O,O-dimethylthiophosphoryl chloride with 2, 6-dichloro-4-methylphenol. For example, in the presence of copper powder, 20% aqueous sodium hydroxide solution is added and the condensation reaction is carried out at 50 ℃ for 30min, insulation 2H, the preparation of methyl phosphorus; Can also be carried out in organic solvent, without the phenol to sodium phenolate, solvent for xylene, acid binding agent potassium carbonate, Catalyst triethylamine or copper powder, methyl phosphorus yield of 90%. |
| category | pesticide |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50: 5000 mg/kg; Oral-mouse LD50: 3500 mg/kg |
| flammability hazard characteristics | flammable; Toxic chloride produced by combustion; nitrogen oxides and phosphorus oxides smoke |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature, separate storage of food additives |
| fire extinguishing agent | foam, water, carbon dioxide, sand |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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View History
Tolclofos-Methyl
二丁硫脲
957-68-6
341-02-6
36776-51-9
硫代苯酚
顶尖除草剂
Naphathoquine Phosphate
O-HYDROXYBENZAMIDE
856867-55-5
二丁硫脲
957-68-6
341-02-6
36776-51-9
硫代苯酚
顶尖除草剂
Naphathoquine Phosphate
O-HYDROXYBENZAMIDE
856867-55-5
Raw Materials for Tolclofos-Methyl